SMAD1/5 signaling in osteoclasts regulates bone formation via coupling factors. [PDF]
PLoS ONE, 2018 Bone remodeling occurs via coupling between bone resorption by osteoclasts and bone formation by osteoblasts. The mechanisms that regulate osteoclast signals to osteoblasts are not well understood.
Amy Tasca +5 more
doaj +1 more source
Studies on Bone-mass Formation within a Theoretical Model [PDF]
IOSR Journal of Pharmacy and Biological Sciences, Volume 9, Issue
4 Ver. II (Jul - Aug 2014), PP 07-20, 2019 Bone-mass formation in human is looked at to understand the underlying dynamics with an eye on healing of bone-fracture and non-unions in non-invasive pathways. Three biological cells osteoblasts, osteoclasts and osteocytes are important players in creating new bone or osseous matter in which quite a few hormones, proteins and minerals have ...
arxiv +1 more source
Staphylococcus aureus Infects Osteoclasts and Replicates Intracellularly
mBio, 2019 The inflammation of bone tissue is called osteomyelitis, and most cases are caused by an infection with the bacterium Staphylococcus aureus. To date, the bone-building cells, osteoblasts, have been implicated in the progression of these infections, but ...
J. Krauss +8 more
semanticscholar +1 more source
The Sealing Zone in Osteoclasts: A Self-Organized Structure on the Bone
International Journal of Molecular Sciences, 2018 Osteoclasts form a specialized cell–matrix adhesion structure, known as the “sealing zone”, during bone resorption. The sealing zone is a dynamic actin-rich structure that defines the resorption area of the bone.
J. Takito, S. Inoue, Masanori Nakamura
semanticscholar +1 more source
Arthritis Research & Therapy, 2020 Background Chondroclasts and osteoclasts have been previously identified as the cells capable of resorbing mineralized cartilage and bone matrices, respectively.
Nazir M. Khan +4 more
doaj +1 more source
The influence of bone surface availability in bone remodelling - A mathematical model including coupled geometrical and biomechanical regulations of bone cells [PDF]
Eng Struct (2013) 47:134-147, 2012 Bone is a biomaterial undergoing continuous renewal. The renewal process is known as bone remodelling and is operated by bone-resorbing cells (osteoclasts) and bone-forming cells (osteoblasts). Both biochemical and biomechanical regulatory mechanisms have been identified in the interaction between osteoclasts and osteoblasts.
arxiv +1 more source
An $\textit{in vivo}$ comparison study between strontium nanoparticles and rhBMP2 [PDF]
Frontiers in Bioengineering and Biotechnology 2020;8:499, 2020 The osteoinductive property of strontium was repeatedly proven in the last decades. Compelling $\textit{in vitro}$ data demonstrated that strontium hydroxyapatite nanoparticles exert a dual action, by promoting osteoblasts-driven matrix secretion and inhibiting osteoclasts-driven matrix resorption. Recombinant human bone morphogenetic protein 2 (rhBMP2)
arxiv +1 more source
Regulation of Osteoclast Differentiation by Myosin X
Scientific Reports, 2017 Osteoclasts begin as mononuclear cells that fuse to form multinuclear cells able to resorb bone. The mechanisms that regulate all the steps of osteoclast differentiation are not entirely known.
Amy Tasca +6 more
doaj +1 more source
p38α MAPK regulates proliferation and differentiation of osteoclast progenitors and bone remodeling in an aging-dependent manner. [PDF]
, 2017 Bone mass is determined by the balance between bone formation, carried out by mesenchymal stem cell-derived osteoblasts, and bone resorption, carried out by monocyte-derived osteoclasts.
Ao, Junping +9 more
core +1 more source
Bone refilling in cortical bone multicellular units: Insights into tetracycline double labelling from a computational model [PDF]
Biomech Model Mechanobiol (2014) 13:185-203, 2012 Bone remodelling is carried out by `bone multicellular units' (BMUs) in which active osteoclasts and active osteoblasts are spatially and temporally coupled. The refilling of new bone by osteoblasts towards the back of the BMU occurs at a rate that depends both on the number of osteoblasts and on their secretory activity.
arxiv +1 more source