Results 61 to 70 of about 111,801 (276)

Modulation of Dopamine Receptors on Osteoblasts as a Possible Therapeutic Strategy for Inducing Bone Formation in Arthritis

Cells, 2022
Rheumatoid arthritis (RA) is associated with systemic osteoporosis, which leads to severe disability and low quality of life. Current therapies target osteoclasts to reduce bone degradation, but more treatment options would be required to promote bone ...
Elena Schwendich, Laura Salinas Tejedor, Gernot Schmitz, Markus Rickert, Jürgen Steinmeyer, Stefan Rehart, Styliani Tsiami, Jürgen Braun, Xenofon Baraliakos, Jörg Reinders, Elena Neumann, Ulf Müller-Ladner, Silvia Capellino   +12 more
doaj   +1 more source

siRNA Delivery via Cross‐Linked Gelatin Microparticles Enables Targeted Modulation of Osteogenic‐Vascular Cross‐Talk: An Advanced Human 3D in Vitro Test System for Therapeutic siRNA

Advanced Healthcare Materials, EarlyView.
Osteogenic‐angiogenic cross‐talk is a vital prerequisite for vascularized bone regeneration. In this study, we investigated the effects of siRNA‐mediated silencing of two inhibitory proteins, Chordin and WWP‐1, via CaP‐NP‐loaded gelatin microparticles in osteogenically differentiated microtissues.
Franziska Mitrach, Jonas Kubat, Stefan Simm, Alexandra H. Springwald, Burak Demir, Anton Liebezeit, Michael C. Hacker, Michaela Schulz‐Siegmund   +7 more
wiley   +1 more source

Endocortical bone loss in osteoporosis: The role of bone surface availability [PDF]

, 2012
Age-related bone loss and postmenopausal osteoporosis are disorders of bone remodelling, in which less bone is reformed than resorbed. Yet, this dysregulation of bone remodelling does not occur equally in all bone regions. Loss of bone is more pronounced
Ausk, Bauchau, Beaupré, Bell, Boivin, Bonewald, Buenzli, Buenzli, Buenzli, Carter, Carter, Compston, Cooper, Currey, Feik, Feng, Grimal, Hambli, Hellmich, Hjelmstad, Huiskes, Iwamoto, Jang, Jee, Keaveny, Komarova, Landau, Lee, Lemaire, Lora, Manolagas, Manson, Martin, Martin, Martin, Mertz, Meulen, Oers, Orwoll, Parfitt, Pivonka, Pivonka, Pivonka, Pivonka, Poliachik, Rieger, Rizzoli, Robling, Rumpler, Ryser, Seeman, Skerry, Stein, Takata, Thomas, Thomas, Timoshenko, Uebelhart, Verborgt, Warner, Webster, Zebaze   +61 more
core   +3 more sources

Fabrication, Properties, and Applications of Scaffolds for Bone Tissue Regeneration

Advanced Materials Technologies, EarlyView.
This review explores cutting‐edge biomaterials and fabrication techniques for scaffolds in bone tissue regeneration. It conducts a critical comparison of various strategies, meticulously analyzes the key contradictions in the field, and outlines an integrated development path spanning from biomaterial selection to clinical application, while ...
Shangsi Chen, Min Wang
wiley   +1 more source

Comparative transcriptomic analysis identifies distinct molecular signatures and regulatory networks of chondroclasts and osteoclasts

Arthritis Research & Therapy, 2020
Background Chondroclasts and osteoclasts have been previously identified as the cells capable of resorbing mineralized cartilage and bone matrices, respectively.
Nazir M. Khan, Kari B. Clifton, Joseph Lorenzo, Marc F. Hansen, Hicham Drissi   +4 more
doaj   +1 more source

Bone Cell Exosomes and Emerging Strategies in Bone Engineering

Biomedicines, 2022
Bone tissue remodeling is a highly regulated process balancing bone formation and resorption through complex cellular crosstalk between resident bone and microenvironment cells.
Sanjana Vig, Maria Helena Fernandes
doaj   +1 more source

Lattice Structures for Bone Replacement: The Intersection of Bone Biomechanics, Lattice Design, and Additive Manufacturing

Advanced Materials Technologies, EarlyView.
This review outlines how understanding bone's biology, hierarchical architecture, and mechanical anisotropy informs the design of lattice structures that replicate bone morphology and mechanical behavior. Additive manufacturing enables the fabrication of orthopedic implants that incorporate such structures using a range of engineering materials ...
Stylianos Kechagias, Maxwell J. Munford, Frederik C.H. Masure, Richard J. van Arkel, Reece N Oosterbeek   +4 more
wiley   +1 more source

Osteoclast.

The Southern medical record
Citation: 'osteoclast' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.11050 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
Kapil Paiwal, Niranzena Panneer Selvam, Abrar Ahmed Alamoudi, Jitin Makker, Anirudha Agnihotry   +4 more
  +5 more sources

The clock genes Period 2 and Cryptochrome 2 differentially balance bone formation [PDF]

, 2010
Background: Clock genes and their protein products regulate circadian rhythms in mammals but have also been implicated in various physiological processes, including bone formation.
Maronde, Erik, Schilling, Arndt, Seitz, Sebastian, Schinke, Thorsten, Schmutz, Isabelle, Horst, Gijsbertus van der, Amling, Michael, Albrecht, Urs   +7 more
core   +1 more source

Engineered Microfluidic Organoid Systems: New Paradigms for Menopause Mechanism Research and Personalized Medicine

Advanced Materials Technologies, EarlyView.
This review explores the integration of microfluidic technology with organoid systems as an innovative platform for studying menopausea complex multi‐organ condition. By enabling precise simulation of inter‐organ communication and hormone responses, microfluidic organoids offer a physiologically relevant model for investigating menopausal syndrome and ...
Qianyi Zhang, He Huang, Hongliang Dong, Qiang Ma, Hongyan Jin   +4 more
wiley   +1 more source