Results 81 to 90 of about 132,467 (326)

Osteocyte-Driven Downregulation of Snail Restrains Effects of Drd2 Inhibitors on Mammary Tumor Cells [PDF]

, 2018
While bone is a frequent target of breast cancer-associated metastasis, little is known about the effects of tumor-bone interactions on the efficacy of tumor-suppressing agents.
Chen, Andy, Fan, Yao, Jalali, Aydin, Li, Bai-Yan, Liu, Shengzhi, Minami, Kazumasa, Nakshatri, Harikrishna, Ogawa, Kazuhiko, Yokota, Hiroki   +8 more
core   +1 more source

Strontium‐Containing Bioactive Glass Nanoparticles Stimulate Osteogenesis and Suppress Osteoclast Formation in Co‐Culture

Advanced Healthcare Materials, EarlyView.
Spherical bioactive glass nanoparticles containing strontium inhibit osteoclast differentiation and activity, but promote osteoblast activity in osteoblast‐osteoclast in vitro co‐culture. The nanoparticles could be used for the treatment of osteoporosis.
Parichart Naruphontjirakul, Alexandra E. Porter, Julian R. Jones   +2 more
wiley   +1 more source

Decreased risk of breast cancer associated with oral bisphosphonate therapy [PDF]

, 2012
Preclinical studies and adjuvant trials using bisphosphonates have found them to have an antitumor effect. Although major advances have been made in chemoprevention strategies with selective estrogen receptor modulators and aromatase inhibitors, their ...
Brufsky, A, Mathew, A
core   +2 more sources

Gentamicin‐Loaded Carbonate Apatite with Dual Antibacterial and Osteogenic Functions for Combating Surgical Site Infections

Advanced Healthcare Materials, EarlyView.
A bone substitute with gentamicin physically precipitated onto the surface of carbonate apatite exhibits prompt drug release, high bactericidal activity, and osteogenic capacity. Efficient antibacterial activity mitigates early postoperative neutrophil accumulation, the status of which may serve as a potential parameter for evaluating the antibacterial
Linghao Xiao, Gabriela Laranjeira Abe, Jun‐Ichi Sasaki, Haruaki Kitagawa, Ririko Tsuboi, Tomoki Kohno, Satoshi Imazato   +6 more
wiley   +1 more source

Mesenchymal Stem Cell‐Derived Apoptotic Micro‐Vesicles Repaired Sciatic Nerve Defect by Regulating Early Inflammatory Microenvironment and Promoting Angiogenesis

Advanced Healthcare Materials, EarlyView.
HUCMSC‐Apo‐mvs enhance peripheral nerve repair by modulating the inflammatory microenvironment (IME), primarily through coordinated actions on three functional cells. They recruit macrophages and promote their polarization from pro‐inflammatory M1 to anti‐inflammatory M2 phenotypes, increasing secretion of IL‐10 and VEGF.
Haolin Liu, Yiben Ouyang, Bo Wang, Xiaochun Zhang, Yanjun Guan, Ruichao He, Yuhui Cui, Junli Wang, Qianru Yao, Yixiao Tan, Xiwei Peng, Xing Xiong, Sice Wang, Dongdong Li, Haofeng Cheng, Tianqi Su, Xiaoyang Fu, Jinjuan Zhao, Mingqian Yu, Yi Wang, Jiang Peng, Yu Wang   +21 more
wiley   +1 more source

Isoliquiritigenin Decreases Bone Resorption and Osteoclast Differentiation [PDF]

, 2022
Kaitlyn M. Joyce, Carmen P. Wong, Ian A. Scriven, Dawn A. Olson, Daniel R. Doerge, Adam J. Branscum, Lara H. Sattgast, William G. Helferich, Russell T. Turner, Urszula T. Iwaniec   +9 more
openalex   +1 more source

Investigation of bone resorption within a cortical basic multicellular unit using a lattice-based computational model

, 2011
In this paper we develop a lattice-based computational model focused on bone resorption by osteoclasts in a single cortical basic multicellular unit (BMU).
Anderson, Baron, Beysens, Block, Boyce, Boyde, Britz, Bronckers, Buenzli, Burger, Chambers, Civitelli, Cohen, Cooper, David W. Smith, Drasdo, Drasdo, Everts, Frost, Frost, Fukushima, García-Aznar, Gerlee, Ghaemi, Glauber, Glazier, Grynpas, Helfrich, Huang, Jaworski, Jeon, Junhwan Jeon, Manolagas, Mansury, Markus, Martin, Martin, Martin, Martin, Martin, Matsuoka, Miller, Mombach, Moshin, Nishiyama, Noble, Othmer, Othmer, Parfitt, Parfitt, Parfitt, Parfitt, Parfitt, Parfitt, Parfitt, Pascal R. Buenzli, Peruani, Peter Pivonka, Peter T. Cummings, Poplawski, Robling, Roodman, Ryser, Schienbein, Schilling, Schweitzer, Stout, Susa, Tappen, van Kampen, van Oers, van Oers, Väänänen, Walker, Zhang   +74 more
core   +2 more sources

Histologic and histomorphometric analysis of bone regeneration with bovine grafting material after 24 months of healing. A case report [PDF]

, 2018
Anorganic bovine bone mineral matrix (ABBMM) has been reported to have osteoconductive properties and no inflammatory or adverse responses when used as grafting material in sinus augmentation procedures.
Belleggia, Fabrizio, DeVillier, Patricia, Guarnieri, Renzo, Testarelli, Luca   +3 more
core   +1 more source

Characterization of an Injectable Poly(vinyl alcohol)‐gelatin Hydrogel for Growth Factor Delivery in an Orthopedic Application

Advanced Healthcare Materials, EarlyView.
This work introduces photo‐crosslinkable tyraminated poly(vinyl alcohol)‐gelatin (PVA‐GT) hydrogels as tunable injectable platforms for tissue engineering and growth factor delivery applications. This schematic illustrates the two developed hydrogel formulations and the experimental workflow used to evaluate their physico‐chemical properties in vitro ...
Alessia Longoni, Gretel S. Major, Sam Arnold, Samuel Tomkins, Eugenia Spessot, Scott Loeffler, Kieran Lau, Richard Tan, Jessica Harte, Roslyn Kemp, Tess Reynolds, Jelena Rnjak‐Kovacina, Gary J. Hooper, Tim B. F. Woodfield, David C. Kieser, Khoon S. Lim   +15 more
wiley   +1 more source

Bone Healing Around Implants in Normal and Medically Compromised Conditions: Osteoporosis and Diabetes

Advanced Healthcare Materials, EarlyView.
xx xx. ABSTRACT Osseointegration of orthopedic and dental implants is influenced by local and systemic factors, including their physicochemical surface properties and the patient's overall health status. Titanium and its alloys have been a longstanding standard for bone implants due to their innate biocompatibility and mechanical properties.
Dainelys Guadarrama Bello, Fabio Variola, Antonio Nanci   +2 more
wiley   +1 more source