Results 81 to 90 of about 109,289 (351)

Transgenic mice for a tamoxifen-induced, conditional expression of the Cre recombinase in osteoclasts. [PDF]

PLoS ONE, 2012
BACKGROUND: Studies on osteoclasts, the bone resorbing cells, have remained limited due to the lack of transgenic mice allowing the conditional knockout of genes in osteoclasts at any time during development or adulthood.
Maria Arantzazu Sanchez-Fernandez, Silvia Sbacchi, Miguel Correa-Tapia, Ronald Naumann, Jennifer Klemm, Pierre Chambon, Samiya Al-Robaiy, Manfred Blessing, Bernard Hoflack   +8 more
doaj   +1 more source

Osteoclast Differentiation [PDF]

Critical Reviews in Oral Biology & Medicine, 1991
The osteoclast is the primary bone resorbing cell. It is a highly specialized multinucleated cell whose primary function is to help in the control of calcium homeostasis. The osteoclast has been very difficult to study because of its relative inaccessability, low numbers, and fragility when isolated from bone.
openaire   +2 more sources

Mesenchymal Stem Cells‐Derived Extracellular Vesicles Mimetics as Osteoinductive Mediators for Bone Healing

Advanced Functional Materials, EarlyView.
Mesenchymal stem cell‐derived nanoghosts (MSC‐NGs) mimic naturally secreted extracellular vesicles (MSC‐EVs) in structure and physicochemical properties but can be synthesized at more translatable yields. As osteogenic agents, MSC‐NGs demonstrate superior outcomes compared to MSC‐EVs.
Antoine Karoichan, Ling Li, Celine J. Agnes, Bettina M. Willie, Maryam Tabrizian   +4 more
wiley   +1 more source

Multiple Idiopathic Cervical Root Resorption: A Challenge for a Transdisciplinary Medical-Dental Team [PDF]

arXiv, 2021
While tooth root resorption is a normal physiological process required for resorption and exfoliation of primary teeth, root resorption of adult teeth is largely pathological. This perspective focuses on multiple idiopathic cervical root resorption (MICRR), an aggressive form of external root resorption that occurs near the cemento-enamel junction (CEJ)
arxiv  

Phagocytosis by osteoclasts [PDF]

The Anatomical Record, 1917
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openaire   +2 more sources

Calcitonin controls bone formation by inhibiting the release of sphingosine 1-phosphate from osteoclasts

Nature Communications, 2014
The hormone calcitonin (CT) is primarily known for its pharmacologic action as an inhibitor of bone resorption, yet CT-deficient mice display increased bone formation.
J. Keller, P. Catalá-Lehnen, A. Huebner, A. Jeschke, T. Heckt, A. Lueth, M. Krause, T. Koehne, J. Albers, J. Schulze, Sarah Schilling, M. Haberland, Hannah Denninger, M. Neven, I. Hermans-Borgmeyer, T. Streichert, S. Breer, F. Barvencik, B. Levkau, B. Rathkolb, E. Wolf, J. Calzada-Wack, F. Neff, V. Gailus-Durner, H. Fuchs, M. D. de Angelis, S. Klutmann, E. Tsourdi, L. Hofbauer, B. Kleuser, J. Chun, T. Schinke, M. Amling   +32 more
semanticscholar   +1 more source

Multifunctional Hydroxyapatite Coated with Gallium Liquid Metal‐Based Silver Nanoparticles for Infection Prevention and Bone Regeneration

Advanced Functional Materials, EarlyView.
A multifunctional hydroxyapatite (HAp) coating integrated with silver‐gallium liquid metal nanoparticles (HAp‐Ag‐GaNPs) exhibits dual antibacterial and osteogenic properties. It effectively inhibits Gram‐positive and Gram‐negative bacteria, including resistant strains, while enhancing bone regeneration.
Ngoc Huu Nguyen, Pengfei Zhang, Fathima Shana Pattar Kadavan, Zhaoning Xu, Tien Thanh Nguyen, Wenshao Li, Manh Tuong Nguyen, Chung Kim Nguyen, Duy Quang Pham, Thi Giang Tuyet Pham, Andrew Hayles, Markos Negash Alemie, Jitraporn Vongsvivut, Vincent Chan, Stephen Peter Kidd, Yunpeng Zhao, Krasimir Vasilev, Vi Khanh Truong   +17 more
wiley   +1 more source

Roles of the RANKL–RANK Axis in Immunity—Implications for Pathogenesis and Treatment of Bone Metastasis

Frontiers in Immunology, 2022
A substantial amount patients with cancer will develop bone metastases, with 70% of metastatic prostate and breast cancer patients harboring bone metastasis.
Bo Li, Pengru Wang, Jian Jiao, Haifeng Wei, Wei Xu, Pingting Zhou   +5 more
doaj   +1 more source

Alterations in the self-renewal and differentiation ability of bone marrow mesenchymal stem cells in a mouse model of rheumatoid arthritis [PDF]

, 2010
Introduction: Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease primarily involving the synovium. Evidence in recent years has suggested that the bone marrow (BM) may be involved, and may even be the initiating site of the disease ...
Bellantuono, I., Coulton, L., Croucher, P.I., Gambardella, A., Hughes, D., Kottam, L., Mohanty, S.T., Nicklin, M.J., Wilson, A.G.   +8 more
core   +3 more sources

Metabolic properties of the osteoclast [PDF]

Bone, 2018
Osteoclasts are defined as cells capable of excavating 3-dimensional resorption pits in bone and other mineralised tissues. They are derived from the differentiation/fusion of promonocytic precursors, and are usually large, multinucleated cells. In common with other cells from this myeloid lineage such as macrophages and dendritic cells, they are ...
Arnett, TR, Orriss, IR
openaire   +4 more sources