Results 21 to 30 of about 31,027 (248)

IL-6 Enhances Osteocyte-Mediated Osteoclastogenesis by Promoting JAK2 and RANKL Activity In Vitro

Cellular Physiology and Biochemistry, 2017
Background/Aims: Evidence suggests that IL-6 affects bone mass by modulating osteocyte communication towards osteoclasts. However, the mechanism by which IL-6 enhances osteocyte-mediated osteoclastogenesis is unclear.
Qing Wu, Xiaokang Zhou, Danqing Huang, Yingchen JI, Feiwu Kang   +4 more
doaj   +2 more sources

Depletion of mmu-miR-185 enhances osteocyte connectivity and suppresses bone fragility through the interaction between ARL8B and RAB5A [PDF]

Stem Cell Research & Therapy
Background Osteocytes, the most abundant cells embedded in bone, possess extensive cytoplasmic extensions that form a complex network facilitating direct communication among osteocytes and with other effector cells in the bone and bone marrow.
Yaqi Cui, Bao Hai, Xiabing Han, Huijie Leng, Dan He, Yimeng Lu, He Wang, Jian Xu, Hongshan Zhao   +8 more
doaj   +2 more sources

Osteocytes and Weightlessness [PDF]

Current Osteoporosis Reports, 2021
Abstract Purpose of Review Osteocytes are considered to be the cells responsible for mastering the remodeling process that follows the exposure to unloading conditions. Given the invasiveness of bone biopsies in humans, both rodents and in vitro culture systems are largely adopted as models for studies in space missions ...
Iandolo, Donata, Strigini, Maura, Guignandon, Alain, Vico, Laurence   +3 more
openaire   +4 more sources

Morphometric Changes of Osteocyte Lacunar in Diabetic Pig Mandibular Cancellous Bone

Biomolecules, 2022
Osteocytes play an important role in bone metabolism. The interactions of osteocytes with the surrounding microenvironment can alter cellular and lacunar morphological changes.
Sheng Yao, Zhibin Du, Lan Xiao, Fuhua Yan, Saso Ivanovski, Yin Xiao   +5 more
doaj   +1 more source

Osteocyte Mechanobiology [PDF]

Current Osteoporosis Reports, 2017
Over the past decades, osteocytes have emerged as mechano-sensors of bone and master regulators of bone homeostasis. This article summarizes latest research and progress made in understanding osteocyte mechanobiology and critically reviews tools currently available to study these cells.Whereas increased mechanical forces promote bone formation ...
Yuhei, Uda, Ehab, Azab, Ningyuan, Sun, Chao, Shi, Paola Divieti, Pajevic   +4 more
openaire   +2 more sources

Osteocyte β3 integrin promotes bone mass accrual and force-induced bone formation in mice

Journal of Orthopaedic Translation, 2023
Background: Cell culture studies demonstrate the importance of β3 integrin in osteocyte mechanotransduction. However, the in vivo roles of osteocyte β3 integrin in the regulation of bone homeostasis and mechanotransduction are poorly defined.
Lei Qin, Zecai Chen, Dazhi Yang, Tailin He, Zhen Xu, Peijun Zhang, Di Chen, Weihong Yi, Guozhi Xiao   +8 more
doaj   +1 more source

The Osteocyte as a Signaling Cell.

Physiological Reviews, 2021
Osteocytes, former osteoblasts encapsulated by mineralized bone matrix, are far from being passive and metabolically inactive bone cells. Instead, osteocytes are multifunctional and dynamic cells capable of integrating hormonal and mechanical signals and
J. Delgado-Calle, T. Bellido
semanticscholar   +1 more source

Partial prevention of glucocorticoid-induced osteocyte deterioration in young male mice with osteocrin gene therapy

iScience, 2022
Summary: Glucocorticoid excess suppresses osteocyte remodeling of surrounding bone minerals, causes apoptosis of osteoblasts and osteocytes, and disrupts bone remodeling, eventually, leading to glucocorticoid-induced osteoporosis and bone fragility ...
Courtney M. Mazur, Christian D. Castro Andrade, Nicha Tokavanich, Tadatoshi Sato, Michael Bruce, Daniel J. Brooks, Mary L. Bouxsein, Jialiang S. Wang, Marc N. Wein   +8 more
doaj   +1 more source

Saos‐2 cells cultured under hypoxia rapidly differentiate to an osteocyte‐like stage and support intracellular infection by Staphylococcus aureus

Physiological Reports, 2023
The intracellular infection of osteocytes represents a clinically important aspect of osteomyelitis. However, few human osteocyte in vitro models exist and the differentiation of immature osteoblasts to an osteocyte stage typically takes at least 4‐weeks
Anja R. Zelmer, Yolandi Starczak, Lucian B. Solomon, Katharina Richter, Dongqing Yang, Gerald J. Atkins   +5 more
doaj   +1 more source

The osteocyte and its osteoclastogenic potential

Frontiers in Endocrinology, 2023
The skeleton is an organ of dual functionality; on the one hand, it provides protection and structural competence. On the other hand, it participates extensively in coordinating homeostasis globally given that it is a mineral and hormonal reservoir. Bone
Aseel Marahleh, H. Kitaura, Fumitoshi Ohori, Takahiro Noguchi, I. Mizoguchi   +4 more
semanticscholar   +1 more source