Results 51 to 60 of about 31,027 (248)
Osteocyte mitochondria regulate angiogenesis of transcortical vessels
Nature CommunicationsTranscortical vessels (TCVs) provide effective communication between bone marrow vascular system and external circulation. Although osteocytes are in close contact with them, it is not clear whether osteocytes regulate the homeostasis of TCVs.
Peng Liao +26 more
semanticscholar +1 more source
Aging, Osteocytes, and Mechanotransduction [PDF]
Current Osteoporosis Reports, 2017 The bone is able to adapt its structure to mechanical signals via the bone remodeling process governed by mechanosensitive osteocytes. With aging, an imbalance in bone remodeling results in osteoporosis. In this review, we hypothesized that changes in lacunar morphology underlie the decreased bone mechanoresponsiveness to mechanical loading with aging ...
Hemmatian, Haniyeh +3 more
openaire +4 more sources
Calcified Tissue International, 2021 Osteocytes are believed to play a crucial role in mechanosensation and mechanotransduction which are important for maintenance of mechanical integrity of bone.
Takuya Ishimoto +4 more
semanticscholar +1 more source
Osteocyte mitochondria inhibit tumor development via STING-dependent antitumor immunity
Science AdvancesBone is one of the most common sites of tumor metastases. During the last step of bone metastasis, cancer cells colonize and disrupt the bone matrix, which is maintained mainly by osteocytes, the most abundant cells in the bone microenvironment. However,
Hao Zhou +19 more
semanticscholar +1 more source
Isolation and culture of primary osteocytes from the long bones of skeletally mature and aged mice
BioTechniques, 2012 The purpose of this work was to establish a methodology to enable the isolation and study of osteocytes from skeletally mature young (4-month-old) and old (22-month-old) mice.
Amber Rath Stern +5 more
doaj +1 more source
The RIP1-RIP3 Complex Mediates Osteocyte Necroptosis after Ovariectomy in Rats. [PDF]
PLoS ONE, 2016 Osteocyte apoptosis has been reported to play a central role in bone remodeling. In addition to apoptosis, other mechanisms may be involved in osteocyte loss. This study aimed to investigate the effect of necroptosis on osteocytes in ovariectomized (OVX)
Hongwang Cui +2 more
doaj +1 more source
Osteocytes Enhance Osteogenesis by Autophagy-Mediated FGF23 Secretion Under Mechanical Tension
Frontiers in Cell and Developmental Biology, 2022 Mechanical stimuli control cell behaviors that are crucial for bone tissue repair. Osteocytes sense extracellular mechanical stimuli then convert them into biochemical signals to harmonize bone remodeling.
Huiyue Xu +9 more
doaj +1 more source
Osteocyte lacunar strain determination using multiscale finite element analysis
Bone Reports, 2020 Osteocytes are thought to be the primary mechanosensory cells within bone, regulating both osteoclasts and osteoblasts to control load induced changes in bone resorption and formation.
Sravan K. Kola +6 more
doaj +1 more source
Osteocytes and Skeletal Pathophysiology [PDF]
Current Molecular Biology Reports, 2015 For many years, osteocytes have been the forgotten bone cells and considered as inactive spectators buried in the bone matrix. We now know that osteocytes detect and respond to mechanical and hormonal stimuli to coordinate bone resorption and bone formation.
Delgado-Calle, Jesus, Bellido, Teresita
openaire +2 more sources
Advanced Healthcare Materials, EarlyView.A 3D biomimetic OS model was developed by bioprinting an OS‐cell‐derived dECM‐enriched bioink with OS spheroids incorporated. The model showed upregulation of known OS prognostic markers and increased resistance to doxorubicin, compared to 2D cultures and scaffold‐free spheroids, making this a more clinically relevant platform for drug discovery ...
Margarida F. Domingues +6 more
wiley +1 more source