Results 111 to 120 of about 138,476 (311)

Autophagy drives osteogenic differentiation of human gingival mesenchymal stem cells

Cell Communication and Signaling, 2019
Background/aim Autophagy is a macromolecular degradation process playing a pivotal role in the maintenance of stem-like features and in the morpho-functional remodeling of the tissues undergoing differentiation.
Chiara Vidoni, Alessandra Ferraresi, Eleonora Secomandi, Letizia Vallino, Chiara Gardin, Barbara Zavan, Carmen Mortellaro, Ciro Isidoro   +7 more
doaj   +1 more source

Heparinization of beta tricalcium phosphate: osteo-immunomodulatory effects [PDF]

, 2018
"This is the pre-peer reviewed version of the following article: A. Diez-Escudero, M. Espanol, M. Bonany, X. Lu, C. Persson, M.-P. Ginebra, Adv. Healthcare Mater.
Bonany Mariñosa, Mar, Díez Escudero, Anna, Español Pons, Montserrat, Ginebra Molins, Maria Pau, Persson, Cecilia   +4 more
core   +2 more sources

A Modular Bioinstructive Platform Reveals Mechanistic Insights into Additive‐Free, Topography‐Driven Osteogenesis

Advanced Healthcare Materials, EarlyView.
Engineered microparticle topographies direct human mesenchymal stem cell osteogenesis without biochemical additives. This osteogenic commitment is driven by canonical Hedgehog signaling and followed by temporal IGF‐II engagement. Two‐photon polymerization demonstrates spatial control, enabling the engineering of topographical gradients that pattern ...
Fatmah I. Ghuloum, Leo A. H. Zeef, Lee A. Stevens, Marco A. N. Domingos, Susan J. Kimber, Mahetab H. Amer   +5 more
wiley   +1 more source

A roadmap of osteogenic differentiation in human mesenchymal stem cells assessed by protein multiplex analysis

European Cells & Materials
Human mesenchymal stem cells (hMSCs) are widely used to model osteogenic differentiation in vitro, yet few studies compare the numerous available protocols.
M Eischen-Loges, Z Tahmasebi Birgani, Y Alaoui Selsouli, L Eijssen, H Rho, M Sthijns, M van Griensven, V LaPointe, P Habibović   +8 more
doaj   +1 more source

Histomorphometric evaluation of bone regeneration induced by biodegradable scaffolds as carriers for dental pulp stem cells in a rat model of calvarial "critical size" defect [PDF]

, 2016
Objective: The aim of this study was to test specific stem cells that could enhance bone formation in combination with specific scaffolds. Methods: Dental Pulp Stem Cells (DPSCs) were seeded with Granular Deproteinized Bovine Bone (GDPB) or Beta ...
ANNIBALI, Susanna, BELLAVIA, Diana, CICCONETTI, Andrea, CRISTALLI, MARIA PAOLA, OTTOLENGHI, Livia, PILLONI, ANDREA, QUARANTA, ROBERTA, Scarano, Antonio   +7 more
core   +1 more source

Start, Stop, Rewind, Repeat—Cyclic Exposure of Adipose Stromal Cells‐derived Cartilage Organoids to Chondrogenic and Proliferative Cues to Achieve Scaled‐up and Customizable Bone Formation by Endochondral Ossification

Advanced Healthcare Materials, EarlyView.
This study exploits the plasticity of ASCs‐derived cartilage organoids which generate a perichondrial layer of MSCs when exposed to cyclic chondrogenic/proliferative cues. Using these organoids as building blocks, we develop (i) Phalange Shaped Tissue Engineered Cartilage (Pa‐TECs), recapitulating endochondral ossification suitable for the treatment of
Pablo Pfister, Emilien Lhospice, Andrés García‐García, Robert Paillaud, Sebastian Jung, Romain Schaller, Elisabeth A. Kappos, Claude Jaquiéry, Tarek Ismail, Dirk J. Schaefer, Michael de Wild, Ivan Martin, Alexandre Kaempfen, Arnaud Scherberich, Adrien Moya   +14 more
wiley   +1 more source

METTL3-Mediated m6A Modification Regulates the Osteogenic Differentiation through LncRNA CUTALP in Periodontal Mesenchymal Stem Cells of Periodontitis Patients

Stem Cells International
Objective. Periodontitis is a chronic inflammatory disease that causes loss of periodontal support tissue. Our objective was to investigate the mechanism by which METTL3-mediated N6-methyladenosine modification regulates the osteogenic differentiation ...
Xin Chen, Yuan Qin, Xian Wang, Hao Lei, Xiaochen Zhang, Houzhuo Luo, Changgang Guo, Weifu Sun, Shishu Fang, Wen Qin, Zuolin Jin   +10 more
doaj   +1 more source

Oral plaque from Type 2 diabetic patients reduces the clonogenic capacity of dental pulp-derived mesenchymal stem cells [PDF]

, 2019
Type 2 diabetes (T2D) is a major metabolic disease and a key epigenetic risk factor for the development of additional clinical complications. Among them, periodontitis (PD), a severe inflammatory disease ascribable to a dysregulated physiology and ...
Bordin, Antonella, Cavarretta, Elena, Chimenti, Isotta, De Falco, Elena, Incerti, Noemi, Pagano, Francesca, Polimeni, Antonella, Saccucci, Matteo, Scaccia, Eleonora, Vozza, Iole   +9 more
core   +1 more source

Packed for Ossification: High‐Density Bioprinting of hPDC Spheroids in HAMA Toward Endochondral Ossification

Advanced Healthcare Materials, EarlyView.
Human periosteum‐derived cell spheroids bioprinted at high density within a hyaluronic acid matrix promote fusion and hypertrophic cartilage formation in vitro. Early encapsulation enhances spheroid interaction and matrix maturation, generating scalable cartilage templates intended for endochondral bone regeneration.
Ane Albillos Sanchez, Maria Paula Marks, Paula Casademunt, Adrián Seijas‐Gamardo, Ioannis Papantoniou, Lorenzo Moroni, Carlos Mota   +6 more
wiley   +1 more source

Functions of CircRNAs in osteogenic differentiation

Yixue xinzhi zazhi, 2021
CircRNAs are a special class of non-coding RNA (ncRNA) molecules. They have a closed circular structure and are formed by reverse splicing by non-classical splicing methods. They coexist in highly differentiated eukaryotes. More and more studies have shown that CircRNAs would change during osteogenic differentiation.
Hui-Xian DONG, Jia-Lin ZHONG, Qian-Zhou JIANG   +2 more
openaire   +1 more source