Results 121 to 130 of about 138,476 (311)

3D Soft Hydrogels Induce Human Mesenchymal Stem Cells “Deep” Quiescence

Advanced Healthcare Materials, EarlyView.
Three‐dimensional soft hydrogels mimicking the bone marrow niche induce deep quiescence in human mesenchymal stem cells. Unlike 2D culture, 3D matrices halt proliferation, regulate cell‐cycle and quiescence markers, and downregulate mTORC1 signaling, preserving stem cell phenotype and therapeutic potential ex vivo.
David Boaventura Gomes, Timo Rademakers, Ana Filipa Henriques Lourenço, Andrea Calore, Clarissa Tomasina, Denis van Beurden, Jinjie Venema, Bryan Chömpff, Hong Liu, Nicole Bouvy, Sandra Camarero‐Espinosa, Lorenzo Moroni   +11 more
wiley   +1 more source

FOXG1 promotes osteogenesis of bone marrow-derived mesenchymal stem cells by activating autophagy through regulating USP14

Communications Biology
The osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) is key for bone formation, and its imbalance leads to osteoporosis.
Yiqi Zhang, Long Zhou, Qin Fu, Ziyun Liu
doaj   +1 more source

MiR-33a Controls hMSCS Osteoblast Commitment Modulating the Yap/Taz Expression Through EGFR Signaling Regulation [PDF]

, 2019
Mesenchymal stromal cells (hMSCs) display a pleiotropic function in bone regeneration. The signaling involved in osteoblast commitment is still not completely understood, and that determines the failure of current therapies being used.
Alessandro, Riccardo, Bellavia, Daniele, Carina, Valeria, Conigliaro, Alice, Costa, Viviana, De Luca, Angela, Fini, Milena, Giavaresi, Gianluca, Raimondi, Lavinia, Salamanna, Francesca   +9 more
core   +1 more source

Mesoporous Silica Nanoparticles in Biomedicine: Advances and Prospects

Advanced Materials, EarlyView.
Mesoporous silica nanoparticles offer unique properties like high surface area, tunable pores, and functionalization. They excel in drug delivery, tissue engineering, and stimuli‐responsive therapies, enabling targeted and controlled treatments. With roles in cancer therapy and diagnostics, their clinical translation requires addressing challenges in ...
Miguel Manzano, María Vallet‐Regí
wiley   +1 more source

Enabling Real‐Time, Non‐Ionizing 3D Imaging of Implantable Magnetic Cements Using Magnetic Particle Imaging

Advanced Materials Interfaces, EarlyView.
This study reports the first implantable resin cement capable of orientation‐sensitive Magnetic Particle Imaging (MPI). By coating the cement with an ultrathin iron film, the authors achieve a strong, angle‐dependent MPI signal that enables non‐ionizing, real‐time tracking of both implant position and orientation, opening new possibilities for safe ...
Gabriel C. Pinto, João M. Costa, Simão P. Fernandes, Gabriela F. Resende, Eduardo T. C. Coimbra, Patrick Vogel, Mariana B. Oliveira, Marco Giardiello, Ricardo M. Silva, Armando A.C.S. Lourenço, Nuno J. O. Silva   +10 more
wiley   +1 more source

Characterization and profiling of immunomodulatory genes of equine mesenchymal stromal cells from non-invasive sources [PDF]

, 2014
Introduction: Mesenchymal stromal cells (MSCs) have been extensively studied for their promising capabilities in regenerative medicine. Although bone marrow is the best-known source for isolating equine MSCs, non-invasive alternative sources such as ...
De Schauwer, Catharina, Goossens, Karen, Govaere, Jan, Hoogewijs, Maarten, Meyer, Evelyne, Piepers, Sofie, Smits, Katrien, Van de Walle, Gerlinde, Van Soom, Ann   +8 more
core   +2 more sources

Influence of the Substrate Temperature on the Growth Mechanism of Allylamine Plasma Polymer Films

Advanced Materials Interfaces, EarlyView.
The influence of the substrate temperature on the growth mechanism of allylamine plasma polymers is investigated by correlating the plasma chemistry and the physico‐chemical properties of the coatings. New insights about the mechanistic formation of functionalized plasma polymers at a molecular level are provided, paving the way toward a better ...
Robin Dantinne, Nathan Vinx, Philippe Leclère, Damien Cossement, Claude Poleunis, Arnaud Delcorte, Damien Thiry   +6 more
wiley   +1 more source

BMP2 commitment to the osteogenic lineage involves activation of Runx2 by DLX3 and a homeodomain transcriptional network

, 2006
Several homeodomain (HD) proteins are critical for skeletal patterning and respond directly to BMP2 as an early step in bone formation. RUNX2, the earliest transcription factor proven essential for commitment to osteoblastogenesis, is also expressed in ...
Aberg, Acampora, Afzal, Amjad Javed, Andre J. van Wijnen, Aronow, Bae, Balint, Banerjee, Banerjee, Beanan, Bendall, Bryan, Cheng, Choi, Depew, Depew, Drissi, Drissi, Ducy, Ferrari, Fujita, Gary S. Stein, Gaur, Ghoul-Mazgar, Harris, Hassan, Hoffmann, Ichida, Ishii, Jane B. Lian, Janet L. Stein, Kim, Komori, Lallemand, Lee, Lengner, Lengner, Lundberg, Maria I. Morasso, Matthew Mandeville, McKeown, Miyama, Mohammad Q. Hassan, Nakashima, Newberry, Otto, Owen, Park, Pratap, Provot, Rahul S. Tare, Robinson, Robledo, Roca, Rosen, Ryoo, Satokata, Satokata, Semba, Shirakabe, Smith, Stricker, Suk Hee Lee, Ten Dijke, Vaes, van Gurp, Xu, Yoshizawa, Zaidi, Zaidi, Zambotti   +71 more
core   +1 more source

Fabrication, Properties, and Applications of Scaffolds for Bone Tissue Regeneration

Advanced Materials Technologies, EarlyView.
This review explores cutting‐edge biomaterials and fabrication techniques for scaffolds in bone tissue regeneration. It conducts a critical comparison of various strategies, meticulously analyzes the key contradictions in the field, and outlines an integrated development path spanning from biomaterial selection to clinical application, while ...
Shangsi Chen, Min Wang
wiley   +1 more source

Comparison of osteogenic differentiation capacity in mesenchymal stem cells derived from human amniotic membrane (AM), umbilical cord (UC), chorionic membrane (CM), and decidua (DC)

Cell & Bioscience, 2019
Background Mesenchymal stem cells (MSCs) have been extensively explored as a promising therapeutic agent in the field of bone tissue engineering due to their osteogenic differentiation ability.
Chongyang Shen, Chuan Yang, Shijun Xu, Hai Zhao   +3 more
doaj   +1 more source