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Nature Reviews Disease Primers, 2022 Osteosarcoma is the most common primary malignant tumour of the bone. Osteosarcoma incidence is bimodal, peaking at 18 and 60 years of age, and is slightly more common in males. The key pathophysiological mechanism involves several possible genetic drivers of disease linked to bone formation, causing malignant progression and metastasis.
Hannah C. Beird +9 more
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Osteosarcoma of Jaw Masquerading as Calcifying Epithelial Odontogenic Tumour- A Diagnostic Dilemma [PDF]
Journal of Clinical and Diagnostic Research, 2022 Osteogenic osteosarcoma is the most widely recognised primary malignant bone tumour involving particularly the appendicular skeleton. Osteosarcoma of jaw including maxillary and mandibular osteosarcoma accounts for about 7% of cases.
Neha Sethi +4 more
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Frontiers in Oncology, 2022 Osteosarcoma is one of the bone malignancies in children and adolescents. Long noncoding RNAs (lncRNAs) have been demonstrated to participate in osteosarcoma development and progression.
Ting Chen +4 more
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The bioinformatic approach identifies PARM1 as a new potential prognostic factor in osteosarcoma
Frontiers in Oncology, 2023 ObjectiveTo explore the key factors affecting the prognosis of osteosarcoma patients.MethodsBased on the GEO dataset and differential expression analysis of normal and osteosarcoma tissues, the gene modules related to the prognosis of osteosarcoma ...
Haijun Feng +3 more
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Journal of Bone and Mineral Research, 2010 Abstract It has been difficult to identify the molecular features central to the pathogenesis of osteosarcoma owing to a lack of understanding of the cell or origin, the absence of identifiable precursor lesions, and its marked genetic complexity at the time of presentation.
Richard, Gorlick, Chand, Khanna
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Aberrant Expression of PAFAH1B3 Affects Proliferation and Apoptosis in Osteosarcoma
Frontiers in Oncology, 2021 Osteosarcoma is a major malignant tumor of bone and soft tissue, which is presenting with early metastasis and a high mortality rate. Platelet activating factor acetylhydrolase 1B3 (PAFAH1B3), a cancer-relevant molecular, was found to play a vital role ...
Jian Fan +7 more
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PKIB involved in the metastasis and survival of osteosarcoma
Frontiers in Oncology, 2022 Osteosarcoma is frequently metastasized at the time of diagnosis in patients. However, the underlying mechanism of osteosarcoma metastasis remains poorly understood.
Rongxue Wan +12 more
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MedComm, 2023 Although great advances have been made over the past decades, therapeutics for osteosarcoma are quite limited. We performed long‐read RNA sequencing and tandem mass tag (TMT)‐based quantitative proteome on osteosarcoma and the adjacent normal tissues ...
Wenchao Zhang +10 more
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