Results 1 to 10 of about 241,082 (329)
Managing the immune microenvironment of osteosarcoma: the outlook for osteosarcoma treatment
Bone Research, 2023 Osteosarcoma, with poor survival after metastasis, is considered the most common primary bone cancer in adolescents. Notwithstanding the efforts of researchers, its five-year survival rate has only shown limited improvement, suggesting that existing ...
Hailong Tian +6 more
semanticscholar +1 more source
Osteosarcoma: A Surveillance, Epidemiology, and End Results program‐based analysis from 1975 to 2017
Cancer, 2022 Osteosarcoma is the most common primary bone malignancy. As a rare cancer, population‐based studies remain small with limited information on finer demographic categories.
S. Cole +3 more
semanticscholar +1 more source
Recent and Ongoing Research into Metastatic Osteosarcoma Treatments
International Journal of Molecular Sciences, 2022 The survival rate for metastatic osteosarcoma has not improved for several decades, since the introduction and refinement of chemotherapy as a treatment in addition to surgery.
Michael A. Harris, C. Hawkins
semanticscholar +1 more source
Frontiers in Immunology, 2022 Osteosarcoma is a primary malignant tumor that tends to threaten children and adolescents, and the 5-year event-free survival rate has not improved significantly in the past three decades, bringing grief and economic burden to patients and society.
Tianyi Zhu +6 more
semanticscholar +1 more source
Nature Communications, 2020 Osteosarcoma is the most frequent primary bone tumor with poor prognosis. Through RNA-sequencing of 100,987 individual cells from 7 primary, 2 recurrent, and 2 lung metastatic osteosarcoma lesions, 11 major cell clusters are identified based on unbiased ...
Yan Zhou +27 more
semanticscholar +1 more source
Oncoimmunology, 2022 The poor progress of immunotherapy on osteosarcoma patients requires deeper delineation of immune tolerance mechanisms in the osteosarcoma microenvironment and a new therapeutic strategy.
Jinti Lin +12 more
semanticscholar +1 more source
The Osteosarcoma Microenvironment: A Complex but Targetable Ecosystem
Cells, 2020 Osteosarcomas are the most frequent primary bone sarcomas, affecting mainly children, adolescents, and young adults, and with a second peak of incidence in elderly individuals.
I. Corre +4 more
semanticscholar +1 more source
The nuclear-cytoplasmic trafficking of a chromatin-modifyng and remodelling protein (KMT2C), in osteosarcoma [PDF]
, 2018 Osteosarcoma is the most common paediatric primary non-hematopoietic bone tumor; the survival is related to the response to chemotherapy and development of metastases.
Carletti, Raffaella +5 more
core +1 more source
Future Directions in the Treatment of Osteosarcoma
Cells, 2021 Osteosarcoma is the most common primary bone sarcoma and is often diagnosed in the 2nd–3rd decades of life. Response to the aggressive and highly toxic neoadjuvant methotrexate-doxorubicin-cisplatin (MAP) chemotherapy schedule is strongly predictive of ...
A. Smrke +5 more
semanticscholar +1 more source
The disintegrin echistatin in combination with doxorubicin targets high-metastatic human osteosarcoma overexpressing ανβ3 integrin in chick embryo and nude mouse models. [PDF]
, 2016 Echistatin, a cyclic RGD peptide, which is an antagonist of αvβ3 integrin (disintegrin), inhibited human osteosarcoma in the chick chorioallontoic membrane (CAM) model and tumor growth and pulmonary metastases in a nude mouse orthotopic model.
Bouvet, Michael +6 more
core +4 more sources