Results 21 to 30 of about 116,442 (313)
Causal effect of chemotherapy received dose intensity on survival outcome: a retrospective study in osteosarcoma [PDF]
BMC Medical Research Methodology 24, 296 (2024), 2023 This study aims to analyse the effects of reducing Received Dose Intensity (RDI) in chemotherapy treatment for osteosarcoma patients on their survival by using a novel approach. In this scenario, toxic side effects are risk factors for mortality and predictors of future exposure levels, introducing post-assignment confounding.
arxiv +1 more source
A Deep Learning Study on Osteosarcoma Detection from Histological Images [PDF]
Biomedical Signal Processing and Control 69 (2021): 102931, 2020 In the U.S, 5-10\% of new pediatric cases of cancer are primary bone tumors. The most common type of primary malignant bone tumor is osteosarcoma. The intention of the present work is to improve the detection and diagnosis of osteosarcoma using computer-aided detection (CAD) and diagnosis (CADx).
arxiv +1 more source
MiR-138 Acts as a Tumor Suppressor by Targeting EZH2 and Enhances Cisplatin-Induced Apoptosis in Osteosarcoma Cells. [PDF]
PLoS ONE, 2016 Chemotherapeutic insensitivity remains a major obstacle to treating osteosarcoma effectively. Recently, increasing evidence has suggested that microRNAs (miRNAs) are involved in drug resistance. However, the effect of miR-138 on cisplatin chemoresistance
Ziqiang Zhu +5 more
doaj +1 more source
From Human Mesenchymal Stromal Cells to Osteosarcoma Cells Classification by Deep Learning [PDF]
Journal of Intelligent & Fuzzy Systems, vol. 37, no. 6, pp.
7199-7206, 2019, 2020 Early diagnosis of cancer often allows for a more vast choice of therapy opportunities. After a cancer diagnosis, staging provides essential information about the extent of disease in the body and the expected response to a particular treatment. The leading importance of classifying cancer patients at the early stage into high or low-risk groups has ...
arxiv +1 more source
DEPDC1 as a crucial factor in the progression of human osteosarcoma
Cancer Medicine, 2023 Objective Novel therapeutic strategies are emerging with the increased understanding of the underlying mechanisms of human osteosarcoma. This current study tends to decipher the potentially critical role of DEP domain‐containing 1 (DEPDC1), a tumor ...
Lin Shen +11 more
doaj +1 more source
Cancer Cell International, 2021 Background Osteosarcoma is the most common primary bone tumor in children and adolescents. However, some patients with osteosarcoma develop resistance to chemotherapy, leading to a poor clinical prognosis.
Hong-Bo Li +6 more
doaj +1 more source
Journal of Orthopaedic Surgery and Research, 2023 Background Osteosarcoma is a common malignant bone tumor, and chemotherapy can effectively improve the prognosis. MicroRNA-331 (MiR-331) is associated with poor cancer outcomes. However, the role of miR-331 in osteosarcoma remains to be explored. Methods
Chenyang Meng +4 more
doaj +1 more source
Acta Pharmaceutica Sinica B, 2022 Osteosarcoma is a kind of bone tumor with highly proliferative and invasive properties, a high incidence of pulmonary metastasis and a poor prognosis. Chemotherapy is the mainstay of treatment for osteosarcoma.
Geni Ye +12 more
doaj
MicroRNA-448 suppresses osteosarcoma cell proliferation and invasion through targeting EPHA7. [PDF]
PLoS ONE, 2017 Osteosarcoma is the most common type of malignant bone tumor, often affecting adolescents and children. MicroRNAs (miRNAs) are a group of small, non-protein coding, endogenous RNAs that play critical roles in osteosarcoma tumorigenesis.
Xiangkun Wu +5 more
doaj +1 more source
Decreased expression of miR-195 mediated by hypermethylation promotes osteosarcoma
Open Medicine, 2022 Osteosarcoma (OS) is the most common type of primary malignant bone tumor. The early lung metastasis of osteosarcoma is one of the main factors of poor prognosis.
Sun Tianhao +6 more
doaj +1 more source