The disintegrin echistatin in combination with doxorubicin targets high-metastatic human osteosarcoma overexpressing ανβ3 integrin in chick embryo and nude mouse models. [PDF]
, 2016 Echistatin, a cyclic RGD peptide, which is an antagonist of αvβ3 integrin (disintegrin), inhibited human osteosarcoma in the chick chorioallontoic membrane (CAM) model and tumor growth and pulmonary metastases in a nude mouse orthotopic model.
Bouvet, Michael +6 more
core +4 more sources
Oleanane triterpenoid CDDO-Me induces apoptosis in multidrug resistant osteosarcoma cells through inhibition of Stat3 pathway. [PDF]
, 2010 BackgroundThe activation of signal transducer and activator of transcription 3 (Stat3) pathway correlates with tumor growth, survival, drug resistance and poor prognosis in osteosarcoma.
Choy, Edwin +6 more
core +4 more sources
Mucoepidermoid carcinoma associated with osteosarcoma in a true malignant mixed tumor of the submandibular region [PDF]
, 2015 True malignant mixed tumor, also known as carcinosarcoma, is a rare tumor of the salivary gland composed of both malignant epithelial and malignant mesenchymal elements.
Cerbelli, B +4 more
core +3 more sources
DEPDC1 as a crucial factor in the progression of human osteosarcoma
Cancer Medicine, 2023 Objective Novel therapeutic strategies are emerging with the increased understanding of the underlying mechanisms of human osteosarcoma. This current study tends to decipher the potentially critical role of DEP domain‐containing 1 (DEPDC1), a tumor ...
Lin Shen +11 more
doaj +1 more source
Decreased expression of miR-195 mediated by hypermethylation promotes osteosarcoma
Open Medicine, 2022 Osteosarcoma (OS) is the most common type of primary malignant bone tumor. The early lung metastasis of osteosarcoma is one of the main factors of poor prognosis.
Sun Tianhao +6 more
doaj +1 more source
Clinical Features and Outcomes Differ between Skeletal and Extraskeletal Osteosarcoma. [PDF]
, 2014 Background. Extraskeletal osteosarcoma (ESOS) is a rare subtype of osteosarcoma. We investigated patient characteristics, overall survival, and prognostic factors in ESOS. Methods.
Boscardin, W John +4 more
core +2 more sources
Cancer Cell International, 2021 Background Osteosarcoma is the most common primary bone tumor in children and adolescents. However, some patients with osteosarcoma develop resistance to chemotherapy, leading to a poor clinical prognosis.
Hong-Bo Li +6 more
doaj +1 more source
ROCK2 Regulates Invasion and Migration of Osteosarcoma Cells
Zhongliu Fangzhi Yanjiu, 2022 Objective To analyze the expression of ROCK2 in osteosarcoma tissues and explore its effect on the invasion and migration of osteosarcoma cells and related mechanism.
SHAN Wenhao +4 more
doaj +1 more source
A patient-derived orthotopic xenograft (PDOX) mouse model of a cisplatinum-resistant osteosarcoma lung metastasis that was sensitive to temozolomide and trabectedin: implications for precision oncology. [PDF]
, 2017 In the present study, we evaluated the efficacy of trabectedin (TRAB) and temozolomide (TEM) compared to cisplatinum (CDDP) on a patient-derived orthotopic xenogrraft (PDOX) of a lung-metastasis from an osteosarcoma of a patient who failed CDDP therapy ...
Dry, Sarah M +15 more
core +1 more source
Journal of Orthopaedic Surgery and Research, 2023 Background Osteosarcoma is a common malignant bone tumor, and chemotherapy can effectively improve the prognosis. MicroRNA-331 (MiR-331) is associated with poor cancer outcomes. However, the role of miR-331 in osteosarcoma remains to be explored. Methods
Chenyang Meng +4 more
doaj +1 more source