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Frontiers in Immunology, 2022 Osteosarcoma is a primary malignant tumor that tends to threaten children and adolescents, and the 5-year event-free survival rate has not improved significantly in the past three decades, bringing grief and economic burden to patients and society.
Tianyi Zhu +6 more
semanticscholar +1 more source
Nature Communications, 2020 Osteosarcoma is the most frequent primary bone tumor with poor prognosis. Through RNA-sequencing of 100,987 individual cells from 7 primary, 2 recurrent, and 2 lung metastatic osteosarcoma lesions, 11 major cell clusters are identified based on unbiased ...
Yan Zhou +27 more
semanticscholar +1 more source
TMED3/RPS15A Axis promotes the development and progression of osteosarcoma
Cancer Cell International, 2021 Background Osteosarcoma is a primary malignant tumor that mainly affects children and young adults. Transmembrane emp24 trafficking protein 3 (TMED3) may be involved in the regulation of malignant cancer behaviors.
Wei Xu +6 more
doaj +1 more source
miR-26a Reverses Multidrug Resistance in Osteosarcoma by Targeting MCL1
Frontiers in Cell and Developmental Biology, 2021 The multidrug resistance (MDR) acquired in human osteosarcoma is a huge obstacle for effective chemotherapy. Recently, microRNA-26a (miR-26a) has been associated with the pathogenesis and progression of osteosarcoma.
Ming Li, Wei Ma
doaj +1 more source
The Osteosarcoma Microenvironment: A Complex but Targetable Ecosystem
Cells, 2020 Osteosarcomas are the most frequent primary bone sarcomas, affecting mainly children, adolescents, and young adults, and with a second peak of incidence in elderly individuals.
I. Corre +4 more
semanticscholar +1 more source
Oncoimmunology, 2022 The poor progress of immunotherapy on osteosarcoma patients requires deeper delineation of immune tolerance mechanisms in the osteosarcoma microenvironment and a new therapeutic strategy.
Jinti Lin +12 more
semanticscholar +1 more source
lncRNA MELTF-AS1 facilitates osteosarcoma metastasis by modulating MMP14 expression
Molecular Therapy: Nucleic Acids, 2021 Osteosarcoma is a highly aggressive cancer common in children and adolescents. There is still a lack of effective treatments for metastatic or recurrent osteosarcoma.
Lei Ding +9 more
doaj +1 more source
Circular RNA circPIP5K1A contributes to cancer stemness of osteosarcoma by miR-515-5p/YAP axis
Journal of Translational Medicine, 2021 Background Osteosarcoma is a common type of bone tumors and frequently occurs in children and adolescents. Cancer stem cells (CSCs) are a unique sub-type of self-renewal cancer cells and the stemness of cancer cells are involved in the spread, recurrence,
Pengxu Shi, Yueting Li, Qingsheng Guo
doaj +1 more source
CEMIP Promotes Osteosarcoma Progression and Metastasis Through Activating Notch Signaling Pathway
Frontiers in Oncology, 2022 Cell migration inducing protein (CEMIP) has been linked to carcinogenesis in several types of cancers. However, the role and mechanism of CEMIP in osteosarcoma remain unclear. This study investigated the role of CEMIP in the progression and metastasis of
Jun Cheng +9 more
doaj +1 more source
The nuclear-cytoplasmic trafficking of a chromatin-modifyng and remodelling protein (KMT2C), in osteosarcoma [PDF]
, 2018 Osteosarcoma is the most common paediatric primary non-hematopoietic bone tumor; the survival is related to the response to chemotherapy and development of metastases.
Carletti, Raffaella +5 more
core +1 more source