Results 21 to 30 of about 134,783 (292)
DEPDC1 as a crucial factor in the progression of human osteosarcoma
Cancer Medicine, 2023 Objective Novel therapeutic strategies are emerging with the increased understanding of the underlying mechanisms of human osteosarcoma. This current study tends to decipher the potentially critical role of DEP domain‐containing 1 (DEPDC1), a tumor ...
Lin Shen +11 more
doaj +1 more source
Decreased expression of miR-195 mediated by hypermethylation promotes osteosarcoma
Open Medicine, 2022 Osteosarcoma (OS) is the most common type of primary malignant bone tumor. The early lung metastasis of osteosarcoma is one of the main factors of poor prognosis.
Sun Tianhao +6 more
doaj +1 more source
Journal of Orthopaedic Surgery and Research, 2022 Background Osteosarcoma is highly malignant. The migration, invasion, and chemoresistance contribute to poor prognosis of osteosarcoma. Research reported that endogenous bornavirus-like nucleoprotein 3 pseudogene (EBLN3P) promotes the progression of ...
Ming-Xia Sun +4 more
doaj +1 more source
ROCK2 Regulates Invasion and Migration of Osteosarcoma Cells
Zhongliu Fangzhi Yanjiu, 2022 Objective To analyze the expression of ROCK2 in osteosarcoma tissues and explore its effect on the invasion and migration of osteosarcoma cells and related mechanism.
SHAN Wenhao +4 more
doaj +1 more source
Telangiectatic Osteosarcoma [PDF]
Journal of Orthopaedic Surgery, 2013 Purpose. To review records of 8 patients with telangiectatic osteosarcoma (TOS) and determine whether pathologic fractures correlate with recurrence and survival. Methods. Records of 4 men and 4 women aged 17 to 44 (mean, 28) years treated for TOS were reviewed. Results. Of the 8 patients, 4 developed a pathologic fracture and 4 did not. In each group,
Jordi Colomina +3 more
openaire +4 more sources
Journal of Orthopaedic Surgery and Research, 2023 Background Osteosarcoma is a common malignant bone tumor, and chemotherapy can effectively improve the prognosis. MicroRNA-331 (MiR-331) is associated with poor cancer outcomes. However, the role of miR-331 in osteosarcoma remains to be explored. Methods
Chenyang Meng +4 more
doaj +1 more source
Cellular functions and molecular mechanisms of ubiquitination in osteosarcoma
Frontiers in Oncology, 2022 Although some advances have been made in the treatment of osteosarcoma in recent years, surgical resection remains the mainstream treatment. Initial and early diagnosis of osteosarcoma could be very difficult to achieve due to the insufficient ...
Jiaxun Song +8 more
doaj +1 more source
Cancer Cell International, 2021 Background Osteosarcoma is the most common primary bone tumor in children and adolescents. However, some patients with osteosarcoma develop resistance to chemotherapy, leading to a poor clinical prognosis.
Hong-Bo Li +6 more
doaj +1 more source
Proceedings of the National Academy of Sciences, 2014 Small-molecule targeted therapies have significantly improved the treatment landscape for many cancers. When a patient’s tumor expresses the protein kinase BCR-ABL or the protein kinase BRAFV600E, or overexpresses the androgen receptor, we now know what to do: treat with the corresponding small molecule that targets the driver oncogene.
Darien E, Reed, Kevan M, Shokat
openaire +2 more sources
The Journal of Bone and Joint Surgery. British volume, 1984 Forty-one cases of parosteal osteosarcoma were reviewed clinically, radiologically and pathologically. The fibrous and cartilaginous elements of each tumour were graded from I to IV for malignancy. Primary intramedullary involvement was found in one third of Grade I lesions, two-thirds of Grade II and nearly 90% of Grade III lesions.
M, Campanacci +5 more
openaire +2 more sources