Results 171 to 180 of about 46,296 (214)

Exploring the therapeutic potential of "Zhi-Zhen" formula for oxaliplatin resistance in colorectal cancer: an integrated study combining UPLC-QTOF-MS/MS, bioinformatics, network pharmacology, and experimental validation. [PDF]

Front Med (Lausanne)
Li Y, Chen K, Li Q, Liu Q, Han H, Liu H, Wang S.   +6 more
europepmc   +1 more source

Identification of key lncRNAs associated with oxaliplatin resistance in colorectal cancer cells and isolated exosomes: From In-Silico prediction to In-Vitro validation. [PDF]

PLoS One
Sahebnasagh R, Deli H, Shadboorestan A, Vakili-Ghartavol Z, Salehi N, Komeili-Movahhed T, Azizi Z, Ghahremani MH.   +7 more
europepmc   +1 more source

Gfi-1 modulates HMGB1-Mediated autophagy to overcome oxaliplatin resistance in colorectal cancer. [PDF]

Heliyon
Liu W, Zhang Z, Zhang L, Jiang X, Chen C, Wu X, Zhao Q.   +6 more
europepmc   +1 more source

RETRACTION: Circular RNA circFBXO11 Modulates Hepatocellular Carcinoma Progress and Oxaliplatin Resistance Through miR-605/FOXO3/ABCB1 Axis. [PDF]

J Cell Mol Med
europepmc   +1 more source

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Establishment of oxaliplatin-resistant gastric cancer organoids: importance of myoferlin in the acquisition of oxaliplatin resistance

Gastric Cancer, 2021
The attainment of drug resistance in gastric cancer (GC) is a problematic issue. Although many studies have shown that cancer stem cells (CSCs) play an important role in the acquisition of drug resistance, there is no clinically available biomarker for predicting oxaliplatin (L-OHP) resistance in relation to CSCs.
Kenji Harada, Naoya Sakamoto, Shoichi Ukai, Yusuke Yamamoto, Quoc Thang Pham, Daiki Taniyama, Ririno Honma, Ryota Maruyama, Tsuyoshi Takashima, Hiroshi Ota, Yuki Takemoto, Kazuaki Tanabe, Hideki Ohdan, Wataru Yasui   +13 more
openaire   +2 more sources

MT2A Promotes Oxaliplatin Resistance in Colorectal Cancer Cells

Cell Biochemistry and Biophysics, 2020
We aimed to understand the molecular mechanism underlying the incidence of Oxaliplatin resistance in colorectal cancer. The Oxaliplatin-resistant (OR) HT29 colorectal cell line was established by long-term exposure to Oxaliplatin. Cell viability and proliferation were determined by the 3-(4,5-dimethyl thiazol-2-yl)-2,5-diphenyltetrazolium bromide and ...
Zhicheng Zhao, Guojing Zhang, Weidong Li
openaire   +2 more sources

The cellular pharmacology of oxaliplatin resistance

European Journal of Cancer, 2002
Oxaliplatin is a third generation platinum compound that differs from cisplatin and carboplatin in having a broader spectrum of antitumour activity. Molecular studies suggest that oxaliplatin adducts are recognised and processed differently than those produced by the earlier generation Pt-containing drugs.
M, Mishima, G, Samimi, A, Kondo, X, Lin, S B, Howell   +4 more
openaire   +2 more sources

Oxaliplatin derived monofunctional triazole-containing platinum(II) complex counteracts oxaliplatin-induced drug resistance in colorectal cancer

Bioorganic Chemistry, 2021
Oxaliplatin-based chemotherapy is the current standard of care in adjuvant therapy for advanced colorectal cancer (CRC). But acquired resistance to oxaliplatin eventually occurs and becoming a major cause of treatment failure. Thus, there is an unmet need for developing new chemical entities (NCE) as new therapeutic candidates to target chemotherapy ...
Yaru, Li, Ziru, Sun, Yujun, Cui, Heming, Zhang, Shunjie, Zhang, Xinyu, Wang, Shengnan, Liu, Qingzhi, Gao   +7 more
openaire   +2 more sources

A fluorescent oxaliplatin derivative for investigation of oxaliplatin resistance using imaging techniques

JBIC Journal of Biological Inorganic Chemistry, 2017
Oxaliplatin is the backbone of chemotherapy for advanced colorectal cancer and undergoes clinical trials for treatment of other tumour entities. However, acquired resistance is a major hurdle. Confocal microscopy is a useful tool to get an insight into the mechanisms of resistance but it requires fluorescent compounds. This work describes the synthesis
Kalayda, Ganna V., Kullmann, Maximilian, Galanski, Mathea Sophia, Gollos, Sabrina   +3 more
openaire   +2 more sources