Results 91 to 100 of about 24,125 (306)
ChemistryOpen, EarlyView.Quinazoline represents an important class of heterocycles with diverse medicinal and pharmacological significance. This review systematically examines scholarly efforts toward understanding different synthetic pathways emphasizing the role of metal and non‐metal catalysts including some miscellaneous reagents employed in the synthesis of quinazoline ...
Neha Manhas +4 more
wiley +1 more source
The Trials and Tribulations of Structure Assisted Design of KCa Channel Activators. [PDF]
, 2019 Calcium-activated K+ channels constitute attractive targets for the treatment of neurological and cardiovascular diseases. To explain why certain 2-aminobenzothiazole/oxazole-type KCa activators (SKAs) are KCa3.1 selective we previously generated ...
Brown, Brandon M +6 more
core
A survey of liquid crystalline oxadiazoles
, 2008 We propose a survey of those oxadiazole compounds, which are mesogenic. We will see that they can have bend-shaped molecules, a biaxial nematic phase, or other interesting peculiarities in the nematic and smectic phase.
Sparavigna, Amelia
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Optimization of anti-proliferative activity using a screening approach with a series of bis-heterocyclic G-quadruplex ligands [PDF]
, 2013 Using a phenotypic screening and SAR optimization approach, a phenyl-bis-oxazole derivative has been identified with anti-proliferative activity, optimized with the use of a panel of cancer cell lines.
CIANCIMINO, Cristina +4 more
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Total Synthesis of Phorbazole B
Molecules, 2020 Phorbazoles are polychlorinated heterocyclic secondary metabolites isolated from a marine sponge and several of these natural products have shown inhibitory activity against cancer cells. In this work, a synthesis of the trichlorinated phorbazole B using
Yngve Guttormsen +5 more
doaj +1 more source
Smart Molecules, EarlyView.In this work, we developed a complex‐mediated nucleophilic aromatic substitution which can generate rich D‐A AIEgens under a facile condition. The AIE mechanism of such AIEgens was unveiled and their application towards fatty liver imaging was exhibited. Abstract Donor‐acceptor (D‐A) compounds are particularly important in optoelectronic and biological
Feng Liu +12 more
wiley +1 more source
Evolutionary and molecular foundations of multiple contemporary functions of the nitroreductase superfamily. [PDF]
, 2017 Insight regarding how diverse enzymatic functions and reactions have evolved from ancestral scaffolds is fundamental to understanding chemical and evolutionary biology, and for the exploitation of enzymes for biotechnology.
Akiva, Eyal +3 more
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24,4,8-Trioxa-21-aza-1,3,6(1,2)-tribenzena-2(2,3)-bicyclo[3.3.0]octanacyclooctaphane
Acta Crystallographica Section E, 2009 The crystal structure of the title compound, C26H25NO3, was determined as part of an investigation of host–guest and electron donor–acceptor complexes. The oxazole and the pyrrole rings both adopt envelope conformations.
P. R. Seshadri +4 more
doaj +1 more source
Access to highly substituted oxazoles by the reaction of α-azidochalcone with potassium thiocyanate
Beilstein Journal of Organic Chemistry, 2020 The reactivity of α-azidochalcones has been explored for the preparation of highly substituted oxazoles via a 2H-azirine intermediate. The azidochalcones, when treated with potassium thiocyanate in the presence of potassium persulfate, lead to 2,4,5 ...
Mysore Bhyrappa Harisha +4 more
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Cell Proliferation, EarlyView.KB2764 interacted with alpha‐enolase (ENO1) and pyruvate kinase M (PKM), ultimately leading to PKM phosphorylation of ENO1. KB2764 consequently increased mitochondrial ATP production and decreased glycolysis dependence. Furthermore, the action of KB2764 extends its application to extend the lifespan of Caenorhabditis elegans.
Yun Haeng Lee +13 more
wiley +1 more source