Results 71 to 80 of about 14,808 (226)

Enantiomeric Separation of New Chiral Azole Compounds

Molecules, 2021
Twelve new azole compounds were synthesized through an ene reaction involving methylidene heterocycles and phenylmaleimide, producing four oxazoles, five thiazoles, and one pyridine derivative, and ethyl glyoxylate for an oxazole and a thiazole compound.
Marziyeh E. Kenari, Joshua I. Putman, Ravi P. Singh, Brandon B. Fulton, Huy Phan, Reem K. Haimour, Key Tse, Alain Berthod, Carl J. Lovely, Daniel W. Armstrong   +9 more
doaj   +1 more source

Microhydration Structures of Protonated Oxazole [PDF]

The Journal of Physical Chemistry A, 2019
The initial microhydration structures of the protonated pharmaceutical building block oxazole (Ox), H+Ox-Wn≤4, are determined by infrared photodissociation (IRPD) spectroscopy combined with quantum chemical dispersion-corrected density functional theory calculations (B3LYP-D3/aug-cc-pVTZ).
Kuntal Chatterjee, Otto Dopfer
openaire   +2 more sources

1,2,6-thiadiazinones as novel narrow spectrum calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2) inhibitors [PDF]

, 1983
We demonstrate for the first time that 4H-1,2,6-thiadiazin-4-one (TDZ) can function as a chemotype for the design of ATP-competitive kinase inhibitors. Using insights from a co-crystal structure of a 3,5-bis(arylamino)-4H-1,2,6-thiadiazin-4-one bound to ...
Asquith, Christopher R.M., Godoi, Paulo H., Counago, Rafael M., Laitinen, Tuomo, Scott, John W., Langendorf, Christopher G., Oakhill, Jonathan S., Drewry, David H., Zuercher, William J., Koutentis, Panayiotis A., Willson, Timothy M., Kalogirou, Andreas S.   +11 more
core   +3 more sources

Optimization of anti-proliferative activity using a screening approach with a series of bis-heterocyclic G-quadruplex ligands [PDF]

, 2013
Using a phenotypic screening and SAR optimization approach, a phenyl-bis-oxazole derivative has been identified with anti-proliferative activity, optimized with the use of a panel of cancer cell lines.
CIANCIMINO, Cristina, Gunaratnam, M, Neidle, S., Ohnmacht, SA, Vignaroli, G   +4 more
core   +1 more source

Metal‐Free Electrophilic Borylative Cyclizations of Alkynes

The Chemical Record, EarlyView.
Metal‐free borylative cyclizations based on electrophilic alkyne activation by boron Lewis acids provide efficient access to borylated hetero‐ and carbocycles. Early studies using B(C6F5)3 displayed limited scope and application, whereas recent ClBcat‐ and BCl3‐based methods enable mild CB and CC/CX bond formation for the synthesis of cycles ...
Jaime Mateos‐Gil, Marcos Humanes, Manuel A. Fernández‐Rodríguez, Patricia García‐García   +3 more
wiley   +1 more source

Sir John Cornforth AC CBE FRS: his synthetic work [PDF]

, 2015
Sir John Cornforth’s work on the synthesis of cholesterol and penicillamine, on the chemistry of oxazoles, the stereochemistry of the synthesis of alkenes, the synthesis of abscisic acid and of dibenzophospholes as mimics of enzyme action, is ...
Abraham E.P., Abraham E.P., Abraham E.P., Callow R.K., Cardwell H.M.E., Cornforth J.W., Cornforth J.W., Cornforth J.W., Cornforth J.W., Cornforth J.W., Cornforth J.W., Cornforth J.W., Cornforth J.W., Cornforth J.W., James R. Hanson, Rupert Purchase   +15 more
core   +1 more source

Unraveling the Physicochemical Landscape of Organoselenium Compounds in Nanocarrier Systems

The Chemical Record, EarlyView.
Main nanocarriers employed to enhance the bioavailability and transport of organoselenium compounds. The image illustrates the key interaction forces that stabilize these organoselenium species in solution, enabling their application in drug delivery systems, catalysis, photoelectronic devices, and sensing technologies. In recent years, publications on
Romelly Eugenia Rojas Ramírez, Tielle Moraes de Almeida, Daiani Canabarro Leite, Gilson Zeni   +3 more
wiley   +1 more source

Analysis of the flavonoid component of bioactive New Zealand mānuka (Leptospermum scoparium) honey and the isolation, characterisation and synthesis of an unusual pyrrole [PDF]

, 2013
The flavonoid components of New Zealand mānuka (Leptospermum scoparium) honey have been quantified in a series of 31 honeys of varying non-peroxide antibacterial activity to clarify discrepancies between previous studies reported in the literature. Total
Alber, Dagmar G., Chan, Ching Wan, Deadman, Benjamin Jade, Harry, Elizabeth, Manley-Harris, Merilyn, Wilkins, Alistair L.   +5 more
core   +2 more sources

Molecular Mechanisms of Resistance and Treatment Efficacy of Delamanid Against Mycobacterium tuberculosis: A Systematic Review

Health Science Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background and Aims Tuberculosis (TB) remains a major global health problem, and treatment progress is increasingly threatened by rising multidrug‐resistant tuberculosis (MDR‐TB). Delamanid (DLM), a nitroimidazole drug, has shown good efficacy and safety against both drug‐susceptible and drug‐resistant Mycobacterium tuberculosis (Mtb) strains.
Md. Mahmudul Islam, Md. Zahid Hasan, Md. Touki Tahamid Tusar, Md. Yeamin Hossain, Md. Motaher Hossain, Md. Abdulla Al Jubayed, Md. Jubaer‐Al‐Abedin, Sheikh Soikot, Shanzida Akther, Jahid Bhuyian, Hafizur Rahman Gazi, B. M. Mahmudul Hasan, Md. Shofiul Azam, Md. Enamul Haque, Abdullah‐Al‐Jubayer, Md. Faruk Hasan, F. M. Ali Haydar, Md. Khalekuzzaman, Md. Torequl Islam, Sohel Hasan   +19 more
wiley   +1 more source

Crystal structure of 3-benzylsulfanyl-6-(5-methyl-1,2-oxazol-3-yl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole

Acta Crystallographica Section E: Crystallographic Communications, 2015
In the title compound, C14H11N5OS2, the triazolo–thiadiazole system is essentially planar (r.m.s. deviation = 0.002 Å) and makes dihedral angles of 6.33 (12) and 42.95 (14)° with the planes of the oxazole and phenyl rings, respectively.
Krishnaiah Vaarla, V. Rajeswar Rao, Mehmet Akkurt   +2 more
doaj   +1 more source