Results 71 to 80 of about 9,421 (215)

Development of a Diversity-Oriented Approach to Oxazole-5-amide Libraries

, 2016
A highly versatile route to oxazole-5-amides is presented. Conversion of readily accessible oxazole-5-trifluoroacetamides into their Boc-protected 5-aminooxazole derivatives provides intermediates amenable to parallel amide synthesis utilizing a reliable,
Mark J. Thompson (1261731), Harry Adams (1327698), Beining Chen (1724752)   +2 more
core   +4 more sources

Crystal structure of 3-benzylsulfanyl-6-(5-methyl-1,2-oxazol-3-yl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole

Acta Crystallographica Section E: Crystallographic Communications, 2015
In the title compound, C14H11N5OS2, the triazolo–thiadiazole system is essentially planar (r.m.s. deviation = 0.002 Å) and makes dihedral angles of 6.33 (12) and 42.95 (14)° with the planes of the oxazole and phenyl rings, respectively.
Krishnaiah Vaarla, V. Rajeswar Rao, Mehmet Akkurt   +2 more
doaj   +1 more source

1,3-Oxazol-4-ylphosphonium salts as new non-peptide inhibitors of furin [PDF]

The Ukrainian Biochemical Journal, 2019
A series of novel triphenylphosphonium derivatives of 1,3-oxazole containing at C2 and C5-positions electron withdrawing or electron-donating groups were synthesized and characterized by 1H, 31P NMR and IR spectroscopy, element analysis and chromato-mass
T. V. Osadchuk, V. K. Kibirev1,2,, O. V. Shybyryn, A. V. Semyroz, Ye. S. Velihina, Е. R. Abdurakhmanova, V. S. Brovarets   +6 more
doaj   +1 more source

Microhydration Structures of Protonated Oxazole [PDF]

The Journal of Physical Chemistry A, 2019
The initial microhydration structures of the protonated pharmaceutical building block oxazole (Ox), H+Ox-Wn≤4, are determined by infrared photodissociation (IRPD) spectroscopy combined with quantum chemical dispersion-corrected density functional theory calculations (B3LYP-D3/aug-cc-pVTZ).
Kuntal Chatterjee, Otto Dopfer
openaire   +2 more sources

Recent Advances in Chemosensors Bearing Pyrazole and Imidazole Rings: An Approach Toward the Detection of Metal Ions Based on these Diazoles

Advanced Sensor Research, Volume 5, Issue 10, October 2026.
This contribution analyzes recent articles (2021–2025) on chemosensors containing pyrazole and imidazole rings for detecting metal ions, using distinctive examples. It focuses on the structural design of probes, their coordination behavior, sensing mechanisms, and analytical performance, including selectivity, sensitivity, working wavelength, and ...
Alexander Ladino‐Bejarano, Carlos Cifuentes, Néstor Bravo, Jaime Portilla   +3 more
wiley   +1 more source

Synthesis of Methylisoxazol‐5(4H)‐One Derivatives Using an ʟ‐Proline‐Functionalized‐MMT Catalyst: Molecular Docking and Cancer Cell Line Cytotoxicity Studies

ChemistrySelect, Volume 11, Issue 38, 13 October 2026.
An efficient and sustainable method for the synthesis of biologically relevant isoxazoles is developed using modified montmorillonite‐K10 (MMT) nanoclay as a heterogeneous catalyst. The catalyst exhibited good stability and reusability over five cycles, with minimal loss of activity (95%–88%). ABSTRACT Guided by green chemistry principles, an efficient
Anushka Servesh, Santhosh Govindaraju, Sumaiya Tabassum, Sankar Ganesh Ramaraj   +3 more
wiley   +1 more source

Modification of the existing maximum residue levels for propyzamide in oilseeds and honey

EFSA Journal, Volume 24, Issue 10, October 2026.
Abstract In accordance with Article 6 of Regulation (EC) No 396/2005, the applicant Corteva submitted a request to the competent national authority in Sweden to modify the existing maximum residue levels (MRLs) for the active substance propyzamide in oilseed rape, mustard seeds, gold of pleasure seeds, linseeds, sesame seeds, hemp seeds, borage seeds ...
European Food Safety Authority (EFSA), Sofia Batista Leite, Giulia Bellisai, Giovanni Bernasconi, Marco Binaglia, Irene Castellan, Anna Federica Castoldi, Arianna Chiusolo, Mathilde Colas, Federica Crivellente, Monica Del Aguila, Lucien Ferreira, Nawelle Id Hammou, Frederique Istace, Anna Lanzoni, Renata Leuschner, Jochem Louisse, Iris Mangas, Silvia Mazzega, Andrea Mioč, Martina Panzarea, Juan Manuel Parra Morte, Simone Rizzuto, Marta Szot, Manuela Tiramani, Alessia Verani   +25 more
wiley   +1 more source

Beyond Simple Mimicry: Next‐Generation Geometric Architectures and Future Paradigms in Small‐Molecule and Macrocyclic Peptidomimetics

Angewandte Chemie, Volume 138, Issue 40, 28 September 2026.
Peptide‐to‐Small Molecule Paradigm: Peptidomimetics have evolved from simple mimicry toward drug‐like scaffolds supported by increasing clinical successes. This Perspective highlights the geometric design principles—linear repetition, convergent fusion, and cyclization—defining the next‐generation peptidomimetic architectures capable of targeting ...
Jesang Lee, Sumin Son, Jeong Yeon Yoo, Ji Hyae Lee, Meehyun Chun, Seung Bum Park   +5 more
wiley   +1 more source

Application of the Dakin−West Reaction for the Synthesis of Oxazole-Containing Dual PPARα/γ Agonists

, 2016
An improved method for the preparation of a series of oxazole-containing dual PPARα/γ agonists is described. A synthetic sequence utilizing a Dakin−West reaction was devised that allows for the introduction of the oxazole ring either late in the ...
Mary Peters (2718172), Lynne A. Hay (3024615), Dawn A. Brooks (2718187), James R. McCarthy (2335417), David Mitchell (407572), Alexander G. Godfrey (3019560)   +5 more
core   +1 more source

Identification and synthesis of metabolites of the new antiglaucoma drug

Research Results in Pharmacology
Introduction: The determination of biotransformation products is an essential part of the preclinical trial of original medicines. These studies have not been conducted before for the new drug 5-[5-(trifluoromethyl)-1,2-oxazole-3-yl]-furan-2-sulfonamide.
Alexander L. Khokhlov, Ilya I. Yaichkov, Anton А. Shetnev, Sergey A. Ivanovsky, Mikhail K. Korsakov, Mikhail A. Alexeev, Olga A. Gasilina, Nikita N. Volkhin, Sergey S. Petukhov   +8 more
doaj   +1 more source