Results 61 to 70 of about 24,125 (306)

Efficient and Stereoselective Synthesis of (Z)‐2‐Oxazolines by Transition Metal‐Free Cycloisomerization of Internal Propargylic Amides in Hexafluoroisopropanol (HFIP)

open access: yesAsian Journal of Organic Chemistry, EarlyView.
(Z)‐2‐oxazolines are available in a stereoselective fashion by cyclization of propargylic amides with internal triple bonds in the presence of HCl generated in situ from hexafluoroisopropanol (HFIP) and TMSCl. Response surface methodology was crucial to optimize the reaction conditions.
Nicholas Jankowski, Norbert Krause
wiley   +1 more source

Total synthesis of the post-translationally modified polyazole peptide antibiotic plantazolicin A [PDF]

open access: yes, 2015
The power of rhodium carbene methodology in chemistry is demonstrated by the synthesis of a structurally complex polyazole antibiotic. Plantazolicin A, a novel soil bacterium metabolite, comprises a linear array of 10 five-membered rings in two ...
Moody, Christopher J.   +2 more
core   +2 more sources

Indole Synthesis via Allenyl Ester; Enantioselective Total Synthesis of Geissoschizoline

open access: yesChemistryEurope, EarlyView.
An indole synthesis via an allenyl ester intermediate at ambient temperature has been developed. The mild reaction conditions allow the use of a broad range of substrates. Notably, the utility of this approach is demonstrated through the asymmetric total synthesis of geissoschizoline, a Strychnos‐type monoterpenoid indole alkaloid.
Sohsuke Moriue   +5 more
wiley   +1 more source

Design and Synthesis of Oxazoline-Based Scaffolds for Hybrid Lewis Acid/Lewis Base Catalysis of Carbon–Carbon Bond Formation [PDF]

open access: yes, 2016
A new class of hybrid Lewis acid/Lewis base catalysts has been designed and prepared with an initial objective of promoting stereoselective direct aldol reactions.
Benoit, Adam R.   +6 more
core   +1 more source

Synthesis and biological activities of the tris-oxazole macrolactone analogs of mycalolides [PDF]

open access: yes, 2012
Mycalolides are tris-oxazole macrolides isolated from the marine sponge Mycale sp., which shows cytotoxic, antifungal, and actin-depolymerizing activities. To develop an efficient synthetic route of mycalolides and to evaluate its functional mechanism of
Ishitsuka Tomoya   +8 more
core   +1 more source

Fused Nitrogen Bridgehead N,O‐Acetals as Versatile Scaffolds: Synthetic Strategies, Mechanism and Applications

open access: yesChemistry – A European Journal, EarlyView.
Fused nitrogen‐bridgehead N,O‐acetals receive specific emphasis as pivotal scaffolds due to their significant role in the bioactivity of medicinally relevant molecules. Significant approaches have been reported on their role as key synthetic building blocks/motifs in the construction of complex organic molecules and their utility as chiral auxiliaries ...
Alexis D. Kouvelas   +2 more
wiley   +1 more source

Chemistry and Biology of Streptogramin A Antibiotics [PDF]

open access: yes, 2007
The streptogramin A antibiotics have proven to be highly active against Gram positive bacteria, particularly methicillin-resistant Staphylococcus aureus. Members of this group of compounds are characterized by a 23-membered macrocycles containing polyene,
Ahmed, Fahim, Donaldson, William
core   +1 more source

Highly selective electrochemical hydrogenation of alkynes: Rapid construction of mechanochromic materials [PDF]

open access: yes, 2019
Electrochemical hydrogenation has emerged as an environmentally benign and operationally simple alternative to traditional catalytic reduction of organic compounds.
Ge, Haibo, Li, Bijin
core   +1 more source

Design, synthesis and biological evaluation of 3-(2-aminooxazol-5-yl)-2H-chromen-2-one derivatives

open access: yesChemistry Central Journal, 2018
Background In view of wide range of biological activities of oxazole, a new series of oxazole analogues was synthesized and its chemical structures were confirmed by spectral data (Proton/Carbon-NMR, IR, MS etc.). The synthesized oxazole derivatives were
Saloni Kakkar   +6 more
doaj   +1 more source

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