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Efficient Access to Chiral 2-Oxazolidinones via Ni-Catalyzed Asymmetric Hydrogenation: Scope Study, Mechanistic Explanation, and Origin of Enantioselectivity

, 2020
Cheap transition metal Ni-catalyzed asymmetric hydrogenation of 2-oxazolones was successfully developed, which provided an efficient synthetic strategy to prepare various chiral 2-oxazolidinones wi...
Yuanhua Liu   +8 more
semanticscholar   +1 more source

2-Oxazolidinone

Acta Crystallographica Section C Crystal Structure Communications, 1997
Redetermination of the crystal structure of the title compound, C3H5NO2, leads to a precise geometry for this molecule that is compared with the conformation of several aryl-substituted oxazolidinones. Molecular cohesion is stabilized by hydrogen bonds between the amine and carbonyl groups.
Wouters, Johan   +2 more
openaire   +2 more sources

Oxazolidinones as chiral auxiliaries in asymmetric aldol reaction applied to natural products total synthesis

, 2020
The aldol condensation is one of the most important C-C bond formation strategies in the art of organic synthesis. Its asymmetric variant, so-called, aldol reaction has found several applications, particularly in the total synthesis of natural products ...
A. Nazari, M. Heravi, Vahideh Zadsirjan
semanticscholar   +1 more source

Metal-free Photocatalytic Synthesis of exo-Iodomethylene 2-Oxazolidinones: An Alternative Strategy for CO2 Valorization with Solar Energy.

ChemSusChem, 2019
A visible-light-promoted metal-free carboxylative cyclization of propargylic amines with CO2 is described to offer exo-iodomethylene 2-oxazolidinones. Incorporation of both CO2 and iodo moiety into the titled compounds is realized efficiently.
Xing He   +3 more
semanticscholar   +1 more source

New oxazolidinones

Current Opinion in Microbiology, 2007
Due to the emergence of resistance to known antibiotics to various organisms, for example, Staphylococcus, Streptococcus, Enterococci, and Pseudomonas there is a renewed interest in the discovery of new antibacterials. Oxazolidinones, totally synthetic class of novel antibacterials, possess activity against drug-resistant Gram-positive pathogens ...
openaire   +2 more sources

The oxazolidinones

Current Infectious Disease Reports, 2002
The need for effective antibiotics to manage the ever increasing frequency of antibiotic-resistant gram-positive infections in much of the developed world has led to the clinical development of the first oxazolidinone antibiotic, linezolid. Linezolid possesses bacteriostatic activity against both antibiotic-susceptible and resistant strains of ...
openaire   +2 more sources

Oxazolidinones: New antibacterial agents

Trends in Microbiology, 1997
The oxazolidinones are a new chemical class of synthetic antibacterial agents that are active orally or intravenously against multidrug-resistant Gram-positive bacteria. Their unique mechanism of action and activity against bacteria that pose therapeutic problems in hospital and community treatments make them promising candidates for antimicrobial ...
C W, Ford   +6 more
openaire   +2 more sources

Fe(II) complexes: reservoirs for Lewis acids and carbenes and their utility in the conversion of CO2 to oxazolidinones

Journal of CO2 Utilization, 2018
Several Fe(II) complexes were prepared as catalysts for the synthesis of oxazolidinones from terminal epoxides, aryl amines, and carbon dioxide. DBU (1,8-diazabicyclo[5.4.0]undec-7-ene) was identified as a highly active co-catalyst for the formation of ...
Fei Chen   +4 more
semanticscholar   +1 more source

DBU and DBU‐Derived Ionic Liquid Synergistic Catalysts for the Conversion of Carbon Dioxide/Carbon Disulfide to 3‐Aryl‐2‐oxazolidinones/[1,3]Dithiolan‐2‐ylidenephenyl‐ amine

Organic Letters, 2016
[reaction: see text] 3-Aryl-2-oxazolidinones are obtained in good yields through the palladium-catalyzed N-arylation of 2-oxazolidinones with aryl bromides. The nature of aryl bromides, phosphine ligands, bases, and solvents strongly affects the reaction outcome.
Binshen Wang   +8 more
semanticscholar   +5 more sources

Two Oxazolidinone Derivatives

Acta Crystallographica Section C Crystal Structure Communications, 1998
The structures of two substituted oxazolidinones, namely, 4-hydroxy­methyl-4-methyloxazolidin-2-one [C5H9NO3, (1)] and 4-ethyl-4-hydroxymethyloxazolidin-2-one [C6H11NO3, (2)], are reported. Bond distances in the two structures are almost identical. The oxazolidinone rings both adopt envelope conformations; the fold in (1) is significantly larger than ...
M. W. Eknoian   +4 more
openaire   +1 more source

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