Results 181 to 190 of about 17,792 (252)

Linezolid in the Focus of Antimicrobial Resistance of <i>Enterococcus</i> Species: A Global Overview of Genomic Studies. [PDF]

Int J Mol Sci
Peykov S, Kirov B, Strateva T.
europepmc   +1 more source

Synthesis of a Bicyclic Aziridine Compound and Subsequent Ring Opening Reactions [PDF]

, 2003
Brombosz, Scott M., Frick, Faculty Advisor, Jeffrey   +1 more
core   +1 more source

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Oxazolidinones: mechanisms of resistance and mobile genetic elements involved.

Journal of Antimicrobial Chemotherapy, 2022
The oxazolidinones (linezolid and tedizolid) are last-resort antimicrobial agents used for the treatment of severe infections in humans caused by MDR Gram-positive bacteria.
A. Brenciani, G. Morroni, S. Schwarz, E. Giovanetti   +3 more
semanticscholar   +1 more source

Efficient methods for the synthesis of chiral 2-oxazolidinones as pharmaceutical building blocks.

Chirality, 2022
Although the wide variety of heterocyclic compounds is common knowledge, chiral 2-oxazolidinones are recognized as some of the most important heterocycles in medicinal chemistry.
K. Okuno, Ryuichi Nishiyori, Koki Abe, Taiki Mori, S. Shirakawa   +4 more
semanticscholar   +1 more source

Novel linezolid-based oxazolidinones as potent anticandidiasis and antitubercular agents.

Bioorganic chemistry (Print), 2022
The quest for new antifungal and antitubercular drugs is a need of the hour because of morbid co-pathogenesis and an increase in immunocompromised patients.
Shaikh Faazil, M. S. Malik, Saleh A. Ahmed, Reem I Alsantali, P. Yedla, Meshari A Alsharif, I. Shaikh, A. Kamal   +7 more
semanticscholar   +1 more source

Recent advances in oxazolidinones as antituberculosis agents.

Future Medicinal Chemistry, 2022
Tuberculosis (TB) is an infectious and fatal disease caused by Mycobacterium tuberculosis (Mtb) and remains a serious public health threat; therefore, the development of new antitubercular agents is a priority for the World Health Organization's End TB ...
Haijia Lu, Huahao Wang, Hongyi Zhao, Dongfeng Zhang   +3 more
semanticscholar   +1 more source

Nonclinical Evaluation of Antibacterial Oxazolidinones Contezolid and Contezolid Acefosamil with Low Serotonergic Neurotoxicity.

Chemical Research in Toxicology, 2021
Linezolid, the principal oxazolidinone antibiotic for therapy of Gram-positive infections, is limited by its myelosuppression and monoamine oxidase (MAO) inhibition, with the latter manifested as serotonergic neurotoxicity.
Wen Wang, Kate Voss, Jinqian Liu, M. Gordeev   +3 more
semanticscholar   +1 more source

Oxazolidinones

Drugs, 2000
The oxazolidinones represent a novel chemical class of synthetic antimicrobial agents. They exhibit an unique mechanism of protein synthesis inhibition and generally display bacteriostatic activity against many important human pathogens, including methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, and penicillin- and ...
D I, Diekema, R N, Jones
openaire   +2 more sources

Oxazolidinone antibiotics

The Lancet, 2001
Many common gram-positive pathogens (eg, Staphylococcus aureus, Enterococcus spp, and Streptococcus pneumoniae) have become increasingly resistant to antimicrobial agents, and new drugs with activity against gram-positive bacteria are urgently needed. The oxazolidinones, a new chemical class of synthetic antimicrobial agent, have a unique mechanism of ...
D J, Diekema, R N, Jones
openaire   +2 more sources

Cu-NPs@COF: A potential heterogeneous catalyst for CO2 fixation to produce 2-oxazolidinones as well as benzimidazoles under moderate reaction conditions

, 2020
Recently CO2 fixation has gained large extent attention due to its potential applications as an abundant C1 resource and variety of value-based fine chemicals that can be synthesized through this fixation.
Resmin Khatun, Surajit Biswas, Imdadul Haque Biswas, S. Riyajuddin, Najirul Haque, K. Ghosh, S. Islam   +6 more
semanticscholar   +1 more source