Results 201 to 210 of about 17,792 (252)

Novel piperidinyloxy oxazolidinone antimicrobial agents

Bioorganic & Medicinal Chemistry Letters, 2001
Oxazolidinone antibacterial agents, where the N-substituted piperazinyl group of eperezolid was replaced with a N-substituted piperidinyloxy moiety, were synthesized and shown to be active against a variety of resistant and susceptible Gram-positive organisms.
M A, Weidner-Wells, C M, Boggs, B D, Foleno, E, Wira, K, Bush, R M, Goldschmidt, D J, Hlasta   +6 more
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Oxazolidinone-Promoted, Torquoselective Nazarov Cyclizations

Organic Letters, 2012
Oxazolidinones are powerful promoters of the Nazarov reaction, enabling the cyclization of conventionally resistant substrates to be achieved under mild conditions. They exert excellent regio- and torquoselective control in both the conventional Nazarov reaction giving cyclopentenones and in the "interrupted" Nazarov reaction, giving more highly ...
Daniel J, Kerr, Michael, Miletic, Jason H, Chaplin, Jonathan M, White, Bernard L, Flynn   +4 more
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Novel oxazolidinone–quinolone hybrid antimicrobials

Bioorganic & Medicinal Chemistry Letters, 2003
Antimicrobial compounds incorporating oxazolidinone and quinolone pharmacophore substructures have been synthesized and evaluated. Representative analogues 2, 5, and 6 display an improved potency versus linezolid against gram-positive and fastidious gram-negative pathogens.
Mikhail F, Gordeev, Corinne, Hackbarth, Michael R, Barbachyn, Lee S, Banitt, James R, Gage, Gary W, Luehr, Marcela, Gomez, Joaquim, Trias, Sara E, Morin, Gary E, Zurenko, Christian N, Parker, Jonathan M, Evans, Richard J, White, Dinesh V, Patel   +13 more
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Linezolid: an oxazolidinone antimicrobial agent

Clinical Therapeutics, 2001
Linezolid is the first oxazolidinone anti-infective agent marketed in the United States. It is indicated for the treatment of nosocomial pneumonia, complicated skin and skin-structure infections caused by methicillin-sensitive or methicillin-resistant Staphylococcus aureus and other susceptible organisms, and vancomycin-resistant Enterococcus faecium ...
H B, Fung, H L, Kirschenbaum, B O, Ojofeitimi   +2 more
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Oxazolidinone: search for highly potent antibacterial

Bioorganic & Medicinal Chemistry Letters, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
Braj Bhushan, Lohray, Vidya Bhushan, Lohray, Brijesh Kumar, Srivastava, Sunil, Gupta, Manish, Solanki, Prashant, Kapadnis, Vijay, Takale, Purvi, Pandya   +7 more
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Oxazolidinone Antibacterial Agents

Current Pharmaceutical Design, 1996
The oxazolidinones are a new class of synthetic antibacterial agents. These compounds demonstrate potent in vitro and in vivo activity against important human pathogens, including multiple antibiotic-resistant strains of gram positive organisms including the staphylococci, streptococci, and enterococci.
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Oxazolidinone Amide Antibiotics

2016
n ...
Zaharia, CA, Cellamare, Saverio, Altomare, Cosimo Damiano   +2 more
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Linezolid: An oxazolidinone antimicrobial agent

American Journal of Health-System Pharmacy, 2002
The pharmacology, antimicrobial activity, pharmacokinetics, clinical efficacy, and adverse effects of linezolid are reviewed. Linezolid, the only oxazolidinone antimicrobial approved for use in the United States, has significant activity against gram-positive bacteria, including penicillin-, cephalosporin-, and vancomycin-resistant species.
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Oxazolidinones

2006
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Oxazolidinone Antibacterial Agents

2011
The “golden age” of antibacterial agent discovery commenced with the identification of the sulfa drugs in the mid 1930s and concluded with the emergence of the quinolones in the early 1960s (Fig. 8.1). It is interesting to note that the vast majority of these early antibiotics were derived from natural products.
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