Results 181 to 190 of about 1,578,374 (306)

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Aerosol Oxidative Potential in the Greater Los Angeles Area: Source Apportionment and Associations with Socioeconomic Position. [PDF]

Environ Sci Technol, 2022
Shen J, Taghvaee S, La C, Oroumiyeh F, Liu J, Jerrett M, Weichenthal S, Del Rosario I, Shafer MM, Ritz B, Zhu Y, Paulson SE.   +11 more
europepmc   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Ambient exposure to fine particulate matter with oxidative potential affects oxidative stress biomarkers in pregnancy. [PDF]

Am J Epidemiol
Meng Q, Liu J, Shen J, Del Rosario I, Janzen C, Devaskar SU, Lakey PSJ, Shiraiwa M, Weichenthal S, Zhu Y, Oroumiyeh F, Banerjee S, Paulson SE, Jerrett M, Paul KC, Ritz B.   +15 more
europepmc   +1 more source

Frailty Exacerbates Disability in Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background To evaluate frailty in severe progressive multiple sclerosis (PMS) and to investigate the underlying mechanisms. Methods This prospective, cross‐sectional, multicenter study enrolled a late severe PMS group requiring skilled nursing (n = 53) and an age, sex, and disease duration‐matched control PMS group (n = 53).
Taylor R. Wicks, Anna Wolska, Diala Ghazal, Dejan Jakimovski, Bianca Weinstock‐Guttman, Alexander Burnham, Niels Bergsland, Michael G. Dwyer, Alan T. Remaley, Robert Zivadinov, Murali Ramanathan   +10 more
wiley   +1 more source

Investigating the Oxidative Potential and <i>In Vitro</i> Toxicity of Ambient Water-Soluble PM₁₀ in an Eastern Mediterranean Site. [PDF]

ACS EST Air
Fang Z, Lai A, Windwer E, Pardo M, Li C, Thenoor Chandran A, Laskin A, Rudich Y.   +7 more
europepmc   +1 more source

Long-term Exposure to Oxidant Gases and Mortality: Effect Modification by PM 2.5 Transition Metals and Oxidative Potential. [PDF]

Epidemiology, 2022
Toyib O, Lavigne E, Traub A, Umbrio D, You H, Ripley S, Pollitt K, Shin T, Kulka R, Jessiman B, Tjepkema M, Martin R, Stieb DM, Hatzopoulou M, Evans G, Burnett RT, Weichenthal S.   +16 more
europepmc   +1 more source

Reduced Muscular Carnosine in Proximal Myotonic Myopathy—A Pilot 1H‐MRS Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Myotonic dystrophy type 2 (proximal myotonic myopathy, PROMM) is a progressive multisystem disorder with muscular symptoms (proximal weakness, pain, myotonia) and systemic manifestations such as diabetes mellitus, cataracts, and cardiac arrhythmias.
Alexander Gussew, Maryam Kargaran, Maik Rothe, Andreas Deistung, Dietrich Stoevesandt, Walter A. Wohlgemuth, David Strube, Thomas Kendzierski, Anna Katharina Kölsch, Maurits Gerhard Abraham Heuschen, Markus Otto, Alexander Mensch   +11 more
wiley   +1 more source

A refined dose metric for nanotoxicology based on surface site reactivity for oxidative potential of engineered nanomaterials. [PDF]

Nanoscale Adv
Alcolea-Rodriguez V, Simeone FC, Dumit VI, Faccani L, Toledo V, Haase A, Coca-López N, Portela R, Bañares MA.   +8 more
europepmc   +1 more source

Sensitivity of PM₁₀ oxidative potential to aerosol chemical composition at a Mediterranean urban site: ascorbic acid versus dithiothreitol measurements. [PDF]

Air Qual Atmos Health, 2023
Clemente Á, Gil-Moltó J, Yubero E, Juárez N, Nicolás JF, Crespo J, Galindo N.   +6 more
europepmc   +1 more source