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Aging is characterized by a number of hallmarks including loss of mitochondrial homeostasis and decay in stress tolerance, among others. Unicellular eukaryotes have been widely used to study chronological aging.
Anna Gröger +5 more
doaj +1 more source
Cytokinin response factor 6 represses cytokinin-associated genes during oxidative stress [PDF]
Cytokinin is a phytohormone that is well known for its roles in numerous plant growth and developmental processes, yet it has also been linked to abiotic stress response in a less defined manner.
Benkova, Eva +10 more
core +3 more sources
The NRF2, Thioredoxin, and Glutathione System in Tumorigenesis and Anticancer Therapies
Cancer remains an elusive, highly complex disease and a global burden. Constant change by acquired mutations and metabolic reprogramming contribute to the high inter- and intratumor heterogeneity of malignant cells, their selective growth advantage, and ...
Morana Jaganjac +3 more
doaj +1 more source
Non-alcoholic fatty liver disease (NAFLD) shows liver fat depots without alcohol consumption. NAFLD does not have specific drug therapies, with a healthy lifestyle and weight loss being the main approaches to prevent and treat NAFLD.
Maria Magdalena Quetglas-Llabrés +9 more
doaj +1 more source
Menadione-induced oxidative stress re-shapes the oxylipin profile of Aspergillus flavus and its lifestyle [PDF]
Aspergillus flavus is an efficient producer of mycotoxins, particularly aflatoxin B1, probably the most hepatocarcinogenic naturally-occurring compound.
Cigliano, Riccardo Aiese +9 more
core +2 more sources
Non-alcoholic fatty liver disease (NAFLD) is a disorder characterized by the excessive accumulation of lipids in the liver parenchyma. To date, there is no effective pharmacological treatment against NAFLD.
Margalida Monserrat-Mesquida +11 more
doaj +1 more source
DNA 3 '-Phosphatase Activity Is Critical for Rapid Global Rates of Single-Strand Break Repair following Oxidative Stress [PDF]
Oxidative stress is a major source of chromosome single-strand breaks (SSBs), and the repair of these lesions is retarded in neurodegenerative disease. The rate of the repair of oxidative SSBs is accelerated by XRCC1, a scaffold protein that is essential
Breslin, Claire, Caldecott, Keith W
core +2 more sources
Expression of Heterologous OsDHAR Gene Improves Glutathione (GSH)-Dependent Antioxidant System and Maintenance of Cellular Redox Status in Synechococcus elongatus PCC 7942. [PDF]
An excess of reactive oxygen species (ROS) can cause severe oxidative damage to cellular components in photosynthetic cells. Antioxidant systems, such as the glutathione (GSH) pools, regulate redox status in cells to guard against such damage ...
Beld, Joris +9 more
core +2 more sources
BACKGROUND: The involvement of free radicals and oxidative stress in HIV infection has been extensively studied, and the benefits of antioxidant supplementation in animal studies have been demonstrated. However, few studies have demonstrated a benefit in
Marcela S Figueira +9 more
doaj +1 more source
Estrés oxidativo y enfermedad por pesticidas: un reto en toxicología
Introducción. En los últimos decenios, la síntesis de compuestos químicos ha producido un alto número de sustancias utilizadas para proteger los cultivos y las cosechas de las plagas.
Sandra Catalina Cortés-Iza +1 more
doaj +1 more source

