Results 151 to 160 of about 11,166 (254)

Structure‐Guided Optimization of a Molecular Glue Targeting the KBTBD4‐HDAC1/2 Complex

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
Structure‐based optimization of the molecular glue degrader UM171 resulted in a near 20‐fold improvement of ternary complex stability but also revealed the challenges of glue discovery. Optimization of UM171, a molecular glue initiating the degradation of neosubstrate HDAC1/2–CoREST–LSD1 through a multiprotein complex formed with KBTBD4, was carried ...
Timea Balo, Zhuoyao Chen, Laurine Palluaud, Arpad Kiss, Tibor Novak, Andras Herner, Alex N. Bullock, Virginie Martiny, Andras Kotschy   +8 more
wiley   +1 more source

Oximes for acute organophosphate pesticide poisoning (Review)

, 2015
BACKGROUND: Acute organophosphorus pesticide poisoning causes tens of thousands of deaths each year across the developing world. Standard treatment involves administration of intravenous atropine and oxime to counter acetylcholinesterase inhibition at ...
Eddleston, Michael, Buckley, Nicholas, Szinicz, Ladislaus   +2 more
core  

Assessing oxime reactivation efficacy using principal component analysis: Insights from nerve agents inhibited human butyrylcholinesterase. [PDF]

ADMET DMPK
Šinko G, Čadež T, Kovarik Z, Hrvat NM.   +3 more
europepmc   +1 more source

Chemistry and Biological Activity of 11<i>H</i>-Indeno[1,2-<i>b</i>]quinoxalin-11-ones and Tryptanthrins, Their Oximes, and Related Analogues. [PDF]

Molecules
Schepetkin IA, Plotnikov MB, Kovrizhina AR, Khlebnikov AI.   +3 more
europepmc   +1 more source

From Mechanisms to Materials: Oximate Reactivity and Emerging Strategies for Organophosphate Detoxification. [PDF]

Chemphyschem
Rodríguez-Dafonte P.
europepmc   +1 more source

Therapeutic Interventions in Organophosphate Poisoning: An Umbrella Review of Systematic Reviews. [PDF]

West J Emerg Med
Chauhan V, Goyal D, Thakur S, Galwankar S, Peredy TR.   +4 more
europepmc   +1 more source

A tale of three mimickers: Amitraz, fipronil, and 2,4-dichlorophenoxyacetic acid poisoning confounding organophosphate toxicity. [PDF]

Turk J Emerg Med
Bhimani KS, Shinde V, Kanani P, Birru JD, Salam MAA.   +4 more
europepmc   +1 more source

Synthesis of Some Oxime Derivatives as Novel Elastase Inhibitors: Molecular Dynamics Studies and Computational Insight. [PDF]

Chem Biodivers
Yaşa H, Ertik O, Sacan O, Hasdemir B, Küçük HB, Yusufoglu AS, Yanardag R.   +6 more
europepmc   +1 more source

Predictors of intermediate syndrome after organophosphorus poisoning and its management in Nepal. [PDF]

Acute Crit Care
Khanal K, Poudel S.
europepmc   +1 more source

Gut-derived biofilm-forming bacteria as a source of catheter-associated infections: inhibitory effects of <i>O</i>-alkyl naringenin derivatives. [PDF]

Front Cell Infect Microbiol
Duda-Madej A, Tabor W, Viscardi S, Oleksy-Wawrzyniak M, Kozłowska J, Gagat P, Grabowiecka A.   +6 more
europepmc   +1 more source