Results 11 to 20 of about 8,623 (211)

A novel mechanism of auxin habituation: upregulation of auxin receptor TRANSPORT INHIBITOR RESPONSE 1 allows cell proliferation independent of external auxin. [PDF]

New Phytol
Summary Exogenously applied auxins are essential for establishing cell lines in tissue cultures and maintaining their proliferation. Cell lines may develop the ability to proliferate even in media lacking auxin, they may become auxin‐habituated. This study investigated the mechanisms underlying this process.
Jelínek P, Müller K, Kobercová E, Přibylová A, Čovanová M, Dobrev PI, Vaculíková R, Vondráková Z, Helusová L, Bírošíková A, Fischer L, Petrášek J.   +11 more
europepmc   +2 more sources

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Novel oxindole/benzofuran hybrids as potential dual CDK2/GSK-3β inhibitors targeting breast cancer: design, synthesis, biological evaluation, and in silico studies

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
The serine/threonine protein kinases CDK2 and GSK-3β are key oncotargets in breast cancer cell lines, therefore, in the present study three series of oxindole-benzofuran hybrids were designed and synthesised as dual CDK2/GSK-3β inhibitors targeting ...
Wagdy M. Eldehna, Sara T. Al-Rashood, Tarfah Al-Warhi, Razan O. Eskandrani, Amal Alharbi, Ahmed M. El Kerdawy   +5 more
doaj   +1 more source

Dimethyl 2-(1-benzyl-2-oxoindolin-3-ylidene)-1,3-dithiole-4,5-dicarboxylate

Acta Crystallographica Section E, 2011
In the title compound, C22H17NO5S2, the dithiole and oxindole rings are almost coplanar [dihedral angle = 2.71 (8)°] and the phenyl ring makes a dihedral angle of 73.65 (5)° with the oxindole ring.
Ayoob Bazgir
doaj   +1 more source

Rauniticine-allo-Oxindole B and Rauniticinic-allo Acid B, New Heteroyohimbine-Type Oxindole Alkaloids from the Stems of Malaysian Uncaria longiflora var. pteropoda

Molecules, 2011
Two new heteroyohimbine-type oxindole alkaloids, rauniticine-allo-oxindole B and rauniticinic-allo acid B, have been successfully isolated from the stems extract of Malaysian Uncaria longiflora var. pteropoda. The structures of the two new alkaloids were
Rohaya Ahmad, Nor Hadiani Ismail, Khalijah Awang, Fatimah Salim   +3 more
doaj   +1 more source

Natural Corynanthe-Type Cholinesterase Inhibitors from Malaysian Uncaria attenuata Korth.: Isolation, Characterization, In Vitro and In Silico Studies

Metabolites, 2023
The Uncaria genus is notable for its therapeutic potential in treating age-related dementia, such as Alzheimer’s disease. A phytochemical study of the leaves of Malaysian Uncaria attenuata Korth., afforded an undescribed natural corynanthe-type oxindole ...
Nelson Jeng-Yeou Chear, Tan Ai Fein Ching-Ga, Kooi-Yeong Khaw, Francisco León, Wen-Nee Tan, Siti R. Yusof, Christopher R. McCurdy, Vikneswaran Murugaiyah, Surash Ramanathan   +8 more
doaj   +1 more source

Synthesis and Biological Evaluation of 5-Fluoro-2-Oxindole Derivatives as Potential α-Glucosidase Inhibitors

Frontiers in Chemistry, 2022
α-Glucosidase inhibitors are known to prevent the digestion of carbohydrates and reduce the impact of carbohydrates on blood glucose. To develop novel α-glucosidase inhibitors, a series of 5-fluoro-2-oxindole derivatives (3a ∼ 3v) were synthesized, and ...
Jing Lin, Qi-Ming Liang, Yuan-Na Ye, Di Xiao, Li Lu, Meng-Yue Li, Jian-Ping Li, Yu-Fei Zhang, Zhuang Xiong, Na Feng, Chen Li   +10 more
doaj   +1 more source

Total synthesis of (±)-coerulescine and (±)-horsfiline

Beilstein Journal of Organic Chemistry, 2010
Wittig olefination–Claisen rearrangement protocol was applied to obtain 3-allyl oxindole. This oxindole was then converted to (±)-coerulescine and (±)-horsfiline.
Mukund G. Kulkarni, Attrimuni P. Dhondge, Sanjay W. Chavhan, Ajit S. Borhade, Yunnus B. Shaikh, Deekshaputra R. Birhade, Mayur P. Desai, Nagorao R. Dhatrak   +7 more
doaj   +1 more source

Methyl 3-[(1H-benzimidazol-1-yl)methyl]-1-methyl-4-(4-methylphenyl)-2′-oxopyrrolidine-2-spiro-3′-1-benzimidazole-3-carboxylate

Acta Crystallographica Section E, 2010
In the title compound, C29H28N4O3, the pyrrolidine ring adopts a twist conformation whereas the oxindole and benzimidazole residues are approximately planar with maximum deviations of 0.159 (1) and 0.011 (1) &#197 ...
S. Kathiravan, K. Ravikumar, B. Sridhar, S. Selvanayagam, R. Raghunathan   +4 more
doaj   +1 more source

Highly Efficient Oxindole‐Based Molecular Photoswitches

Chemistry – A European Journal, 2023
Abstract3‐Benzylidene‐indoline‐2‐ones play a prominent role in the pharmaceutical industry due to the diverse biomedical applications of oxindole heterocycles. Despite the extensive reports on their biological properties, these compounds have hardly been studied for their photochemical activity.
Daniel Doellerer, Daisy R. S. Pooler, Ainoa Guinart, Stefano Crespi, Ben L. Feringa   +4 more
openaire   +4 more sources