Results 31 to 40 of about 8,623 (211)

Enantioselective Michael Addition of 3-Aryl-Substituted Oxindoles to Methyl Vinyl Ketone Catalyzed by a Binaphthyl-Modified Bifunctional Organocatalyst

Molecules, 2012
The enantioselective conjugate addition reaction of 3-aryl-substituted oxindoles with methyl vinyl ketone promoted by binaphthyl-modified bifunctional organocatalysts was investigated.
Saet Byeol Woo, Hyun Joo Lee, Dae Young Kim   +2 more
doaj   +1 more source

Synthesis, Biological Evaluation and In Silico Studies of Certain Oxindole–Indole Conjugates as Anticancer CDK Inhibitors

Molecules, 2020
On account of their overexpression in a wide range of human malignancies, cyclin-dependent kinases (CDKs) are among the most validated cancer targets, and their inhibition has been featured as a valuable strategy for anticancer drug discovery.
Tarfah Al-Warhi, Ahmed M. El Kerdawy, Nada Aljaeed, Omnia E. Ismael, Rezk R. Ayyad, Wagdy M. Eldehna, Hatem A. Abdel-Aziz, Ghada H. Al-Ansary   +7 more
doaj   +1 more source

Harnessing Photoenzymatic Systems for Intermolecular C–H Fluorination

Angewandte Chemie, Volume 138, Issue 5, 28 January 2026.
Despite the remarkable versatility of enzymes for catalyzing complex organic transformations under mild aqueous conditions, no biocatalytic system has been reported for intermolecular C–H fluorination. A radical photoenzymatic approach is introduced that leverages a designed de novo protein scaffold with an unnatural amino acid to achieve precise ...
Yu Zhou, Danielle Lawson, Zihan Zhang, Yunling Deng, Hejun Deng, Connor J. O'Dea, Zachariah A. Page, Yi Lu   +7 more
wiley   +2 more sources

Electrochemical Detection of Chloride Ions by Copper (II) Complex with Mixed Ligand of Oxindole Derivative and Dithiocarbamates Moiety

Applied Sciences, 2019
The present work describes the synthesis of a new copper (II) complex with bidentate ligands based on oxindole (indolin-2-one) derivatives, namely: 1H,1′H,1″H-[2,3′:2′,3″-terbenzo[b]pyrrol]-2″(3″H)-one (L1) and [sodium diethyldithiocarbamate (DTC)] (L2 ...
M. Nazim, Abdullah, Sadia Ameen, M. Shaheer Akhtar, Hyung-Shik Shin   +4 more
doaj   +1 more source

Visible light mediated aerobic oxidative hydroxylation of 2-oxindole-3-carboxylate esters: an alternative approach to 3-hydroxy-2-oxindoles

Heterocyclic Communications, 2020
A convenient aerobic oxidative hydroxylation of 3-substituted oxindoles under mild reaction conditions is described herein. This process was accomplished by the activation of molecular oxygen in the air in the presence of a photocatalyst under the ...
Wang Jinge, Osman Siyitemer, Lu Xinjiang, Chen Junyi, Xia Xu-Dong   +4 more
doaj   +1 more source

Acid‐ and Nucleophile‐Gated Photoisomerization of Phosphaindirubin

Angewandte Chemie International Edition, EarlyView.
Triply gated isomerization: In polar solvents, a phosphorus‐containing indirubin photoswitch undergoes visible‐light‐driven Z→E isomerization only when protonated, and reverts thermally via nucleophile‐catalyzed back‐isomerization. This three‐way control by light, acid, and nucleophile enables reversible photoisomerization.
Jacob Jan van der Wal, Jorn D. Steen, Ann‐Kathrin Rückert, Roman Yu. Peshkov, Michiel F. Hilbers, P. Tim Prins, Wybren Jan Buma, Andreas Orthaber, Stefano Crespi   +8 more
wiley   +1 more source

Synthesis of New Indole Derivatives Structurally Related to Donepezil and Their Biological Evaluation as Acetylcholinesterase Inhibitors

Molecules, 2012
New series of indole derivatives analogous to donepezil, a well known anti-Alzheimer and acetylcholinesterase inhibitor drug, was synthesized. A full chemical characterization of the new compounds is provided.
Samar I. Faggal, Lamia W. Mohamed, Mona M. Kamel, Mohamed M. Ismail   +3 more
doaj   +1 more source

The Diarylprolinol Silyl Ethers: After 20 Years Still Opening New Doors in Asymmetric Catalysis

Angewandte Chemie International Edition, EarlyView.
Catalysis Rules! The year 2025 marks the 20th anniversary of diarylprolinol silyl ethers in asymmetric organocatalysis. During the first decade after their discovery, these catalysts have been established as one of the most versatile tools in aminocatalysis. Although now considered mature, recent years have witnessed renewed innovation.
Enrico Marcantonio, René Slot Bitsch, Karl Anker Jørgensen   +2 more
wiley   +1 more source

Discovery and Anticancer Screening of Novel Oxindole-Based Derivative Bearing Pyridyl Group as Potent and Selective Dual FLT3/CDK2 Kinase Inhibitor

Pharmaceuticals
Protein kinases regulate cellular activities and make up over 60% of oncoproteins and proto-oncoproteins. Among these kinases, FLT3 is a member of class III receptor tyrosine kinase family which is abundantly expressed in individuals with acute leukemia.
Aya Soudi, Onur Bender, Ismail Celik, Amer Ali Abd El-Hafeez, Rumeysa Dogan, Arzu Atalay, Eslam B. Elkaeed, Aisha A. Alsfouk, Elshimaa M. N. Abdelhafez, Omar M. Aly, Wolfgang Sippl, Taha F. S. Ali   +11 more
doaj   +1 more source

Harnessing Toluene Solvent as a Reactant: Regioselective Benzyl Radical Addition to Multi‐π 1,5‐Enynes in a Copper‐Catalyzed Cascade to Indenes

Chemistry – A European Journal, EarlyView.
A copper‐catalyzed three‐component radical cascade of 1,5‐enynes with toluene and benzoic acids enables regioselective benzyl radical addition to multi‐Π systems, efficiently delivering polysubstituted indenes from an abundant solvent feedstock. ABSTRACT C─H activation of toluene generates a benzyl radical that undergoes C─C coupling, converting an ...
Saideh Rajai‐Daryasarei, Fatemeh Chahardehi, Mohammad Mahdi Sharifani, Morteza Jamshidi, Robert Stranger, Frank Rominger, Alireza Ariafard, Saeed Balalaie   +7 more
wiley   +1 more source