Results 81 to 90 of about 8,483 (210)

Ag/Pyridine Co-Mediated Oxidative Arylthiocyanation of Activated Alkenes

open access: yesMolecules, 2018
An efficient Ag/pyridine co-mediated oxidative arylthiocyanation of activated alkenes via radical addition/cyclization cascade process was developed.
De-Long Kong   +5 more
doaj   +1 more source

A copper-catalyzed arylation of tryptamines for the direct synthesis of aryl pyrroloindolines [PDF]

open access: yes, 2012
An operationally simple, copper-catalyzed arylation of N-tosyltryptamines provides direct access to C3-aryl pyrroloindolines. A range of electron-donating and electron-withdrawing substituents is tolerated on both the indole backbone and the aryl ...
Chuang, Kangway V.   +2 more
core   +1 more source

Baseline multi‐omics signatures could predict therapeutic response to neoadjuvant anti‐PD‐1 immunochemotherapy in non‐small‐cell lung cancer

open access: yesClinical and Translational Medicine, Volume 16, Issue 1, January 2026.
Overview of study design. Metagenomic and plasma/fecal metabolomic studies were performed in 44 NSCLC patients who underwent neoadjuvant tislelizumab therapy plus platinum ‐ based doublet chemotherapy. Abstract Background Neoadjuvant anti‐programmed cell death 1 (PD‐1) immunochemotherapy has shown promising efficiency in the treatment of early‐stage ...
Ailing Cao   +11 more
wiley   +1 more source

Synthesis of chiral 3-substituted 3-amino-2-oxindoles through enantioselective catalytic nucleophilic additions to isatin imines

open access: yesBeilstein Journal of Organic Chemistry, 2018
This review collects the recent developments in the synthesis of chiral 3-substituted 3-amino-2-oxindoles based on enantioselective catalytic nucleophilic additions to isatin imines published since the beginning of 2015.
Hélène Pellissier
doaj   +1 more source

Construction of Spirooxindole Skeleton Through Intramolecular Dieckmann Cyclization

open access: yesNatural Products and Bioprospecting, 2017
A highly efficient and direct approach was developed to construct the structurally diverse spirooxindole skeleton, which is an important basic motif in natural products.
Ting Wu, Zhiqiang Pan, Chengfeng Xia
doaj   +1 more source

Selective β-oxidation of α-sulfanyl amides [PDF]

open access: yes, 2011
A selective β-oxidation of a series of α-sulfanyl amides to the corresponding β-oxo-α-sulfanyl amides is described. This selective efficient oxidation of an unfunctionalised methyl or methylene group occurs under mild conditions, involving three ...
Bateman, Lorraine M.   +4 more
core   +1 more source

Effective Low‐Temperature Oxidative Denitrogenation With Sulfated Titania Supported on Porous Carbon

open access: yesSmall Structures, Volume 7, Issue 1, January 2026.
We report the first synthesis of the novel S‐TiO2/C catalyst on highly porous pANI‐derived carbon. It achieved outstanding oxidative denitrogenation (ODN) performance, completing conversion of 1000 ppm indole in 60 min at 45°C. This is due to well‐dispersed S‐TiO2 facilitating H2O2 activation and •OH radical generation, and it proved highly reusable ...
Imteaz Ahmed   +2 more
wiley   +1 more source

Diastereo- and enantioselective [3 + 3] cycloaddition of spirocyclopropyl oxindoles using both aldonitrones and ketonitrones

open access: yesNature Communications, 2017
Chiral spirocyclic compounds are important structural motifs for drug discovery. Here, the authors report a synthetic route to spirocycles based on enantioselective cycloaddition of activated spirocyclopropyl oxindoles, which act as donor-acceptor ...
Peng-Wei Xu   +6 more
doaj   +1 more source

1H-Imidazol-4(5H)-ones and thiazol-4(5H)-ones as emerging pronucleophiles in asymmetric catalysis [PDF]

open access: yes, 2016
Asymmetric catalysis represents a very powerful tool for the synthesis of enantiopure compounds. In this context the main focus has been directed not only to the search for new efficient chiral catalysts, but also to the development of efficient ...
Mielgo Vicente, María Antonia   +1 more
core   +2 more sources

The Traditional Chinese Medicine Compound Hezi Qingyou Formula Controls the MAPK Signaling Pathway for Alleviating Gastric Ulcer Induced by Acetic Acid in Rats

open access: yesJournal of Immunology Research, Volume 2026, Issue 1, 2026.
In clinical practice, Hezi Qingyou Formula (HZQYF) has been observed to effectively alleviate clinical symptoms associated with gastri ulcers, though its precise mechanism of action remains unclear. To investigate the effects of HZQYF on gastric ulcers, we established a rat model of gastric ulcer and examined its impact on ulcer area, pathological ...
Zhong Feng   +12 more
wiley   +1 more source

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