Results 1 to 10 of about 60,467 (293)

Notch1 Modulation of Cellular Calcium Regulates Mitochondrial Metabolism and Anti-Apoptotic Activity in T-Regulatory Cells

Frontiers in Immunology, 2022
As the major hub of metabolic activity and an organelle sequestering pro-apoptogenic intermediates, mitochondria lie at the crossroads of cellular decisions of death and survival.
Neetu Saini, Neetu Saini, Sowmya Lakshminarayanan, Priyanka Kundu, Apurva Sarin   +4 more
doaj   +1 more source

Changes in Oxidative Phosphorylation Activity in Fibroblasts at p38 MAPK Pathway Inhibition [PDF]

International Journal of Biomedicine, 2019
Background: Mitochondrial oxidative phosphorylation (OxPhos) accounts for more than 90% of the cellular ATP production, plays the role in reactive oxygen species (ROS) generation and programmed cell death.
Irina A Shurygina, Irina S Trukhan, Nataliya N Dremina, Michael G Shurygin   +3 more
doaj   +1 more source

Moderate Exercise Modulates Tumor Metabolism of Triple-Negative Breast Cancer

Cells, 2020
Triple-negative breast cancer (TNBC) stands out for its aggressiveness and accelerated rate of proliferation. Evidence shows that exercise may exert antitumorigenic effects, but the biochemical mechanisms underlying them remain unclear. Our objective was
Anderson Vulczak, Anderson de Oliveira Souza, Gustavo Duarte Ferrari, Ana Elisa Caleiro Seixas Azzolini, Gabriela Pereira-da-Silva, Luciane Carla Alberici   +5 more
doaj   +1 more source

TEAD4 as an Oncogene and a Mitochondrial Modulator

Frontiers in Cell and Developmental Biology, 2022
TEAD4 (TEA Domain Transcription Factor 4) is well recognized as the DNA-anchor protein of YAP transcription complex, which is modulated by Hippo, a highly conserved pathway in Metazoa that controls organ size through regulating cell proliferation and ...
Sheng-Chieh Hsu, Sheng-Chieh Hsu, Ching-Yu Lin, Yen-Yi Lin, Colin C. Collins, Chia-Lin Chen, Chia-Lin Chen, Hsing-Jien Kung, Hsing-Jien Kung, Hsing-Jien Kung, Hsing-Jien Kung   +10 more
doaj   +1 more source

Versatile Functional Energy Metabolism Platform Working From Research to Patient: An Integrated View of Cell Bioenergetics

Frontiers in Toxicology, 2022
Mitochondrial dysfunctions that were not discovered during preclinical and clinical testing have been responsible for at least restriction of use as far as withdrawal of many drugs.
Sylvain Loric, Marc Conti
doaj   +1 more source

Myoglobin‐mediated lipid shuttling increases adrenergic activation of brown and white adipocyte metabolism and is as a marker of thermogenic adipocytes in humans

Clinical and Translational Medicine, 2022
Background Recruitment and activation of brown adipose tissue (BAT) results in increased energy expenditure (EE) via thermogenesis and represents an intriguing therapeutic approach to combat obesity and treat associated diseases.
Lisa Christen, Helen Broghammer, Inka Rapöhn, Kevin Möhlis, Christian Strehlau, Aleix Ribas‐Latre, Claudia Gebhardt, Lisa Roth, Kerstin Krause, Kathrin Landgraf, Antje Körner, Kerstin Rohde‐Zimmermann, Anne Hoffmann, Nora Klöting, Adhideb Ghosh, Wenfei Sun, Hua Dong, Christian Wolfrum, Tienush Rassaf, Ulrike B. Hendgen‐Cotta, Michael Stumvoll, Matthias Blüher, John T. Heiker, Juliane Weiner   +23 more
doaj   +1 more source

In vitro assessment of stearyl triphenyl phosphonium toxicity in drug-resistant tumor cells

4 open, 2022
Introduction: The triphenyl phosphonium residue is a well-documented mitochondriotropic that has been shown to improve the accumulation of biomolecules in mitochondria. Stearyl triphenyl phosphonium (STPP) modified liposomes have been shown to facilitate
Shah Shrey, Ouellette Miller, D’Souza Gerard G. M.   +2 more
doaj   +1 more source

Mechanisms of venetoclax resistance and solutions

Frontiers in Oncology, 2022
The BCL-2 inhibitor venetoclax is currently approved for treatment of hematologic diseases and is widely used either as monotherapy or in combination strategies.
Jiachen Liu, Yidong Chen, Lihua Yu, Lihua Yang   +3 more
doaj   +1 more source

Mitochondrial complex II and reactive oxygen species in disease and therapy

Redox Report, 2020
Increasing evidence points to the respiratory Complex II (CII) as a source and modulator of reactive oxygen species (ROS). Both functional loss of CII as well as its pharmacological inhibition can lead to ROS generation in cells, with a relevant impact ...
Katerina Hadrava Vanova, Michal Kraus, Jiri Neuzil, Jakub Rohlena   +3 more
doaj   +1 more source

Natural and Induced Mitochondrial Phosphate Carrier Loss: DIFFERENTIAL DEPENDENCE OF MITOCHONDRIAL METABOLISM AND DYNAMICS AND CELL SURVIVAL ON THE EXTENT OF DEPLETION. [PDF]

, 2016
The relevance of mitochondrial phosphate carrier (PiC), encoded by SLC25A3, in bioenergetics is well accepted. However, little is known about the mechanisms mediating the cellular impairments induced by pathological SLC25A3 variants.
Acoba, Michelle G., Anderson-Pullinger, Lauren, Claypool, Steven M., Golenár, Tünde, Gál, Aniko, Hajnóczky, György, Li, Qipei, Moffat, Cynthia, Seifert, Erin L., Sondheimer, Neal   +9 more
core   +2 more sources