Results 41 to 50 of about 22,050 (201)

No pain, no strain: Targin® mitigates pain and constipation following spinal cord injury

Annals of Clinical and Translational Neurology, 2023
Background Opioids effectively reduce chronic pain, but present significant side effects including opioid‐induced constipation. Oxycodone/naloxone decreases pain and constipation in cancer patients, however its effect on spinal cord injury population ...
Rahul Sachdeva, Ali Hosseinzadeh, Aaron Rizzardo, Andrea Maharaj, Michael Berger, Andrei Krassioukov   +5 more
doaj   +1 more source

Oxycodone, an opioid like the others?

Frontiers in Psychiatry, 2023
The over-prescription of opioid analgesics is a growing problem in the field of addiction, which has reached epidemic-like proportions in North America. Over the past decade, oxycodone has gained attention as the leading opioid responsible for the North ...
Nicolas Marie, Florence Noble
doaj   +1 more source

Stability of oxycodone in compound sodium lactate

Journal of Pharmacy Practice and Research, EarlyView.
Abstract Background It is sometimes clinically desirable to administer oxycodone concurrently with compound sodium lactate via the same intravenous (IV) line; however, there are limited stability and compatibility data for this combination. Aim To determine the stability of oxycodone in compound sodium lactate IV solution.
The‐Phung To, Michael Ching, Philip Zeglinski, Ljubica Trajceska, Yvonne Lau, Kate Schimmelbusch, Kent Garrett   +6 more
wiley   +1 more source

Impact of Co‐Morbid Immunocompromise in HPV‐Associated Oropharyngeal Squamous Cell Carcinoma

The Laryngoscope, EarlyView.
Among patients with surgically resected Human Papillomavirus positive (HPV+) oropharyngeal squamous cell carcinoma (OPSCC), immunocompromised patients had significantly worse overall survival compared to the non‐compromised group; however, these exploratory findings should be interpreted cautiously.
Maxwell L. Weng, Tereza Vitkovska, Song Hon Hwang, Lauran K. Evans, Hong‐Ho Yang, Christopher Dann, Dipti Sajed, Maie A. St. John   +7 more
wiley   +1 more source

Effect of repeated intraperitoneal injections of different concentrations of oxycodone on immune function in mice

Frontiers in Pharmacology
BackgroundThe effect of oxycodone as an opioid receptor agonist on immune function is still controversial. In this study, we investigated the possible effects of oxycodone on immune function in mice and its possible mechanisms of action.MethodsBy ...
Sumeng Chen, Jingjing Liu, Shaoqiang Huang   +2 more
doaj   +1 more source

Molecular mechanisms underlying the enhanced analgesic effect of oxycodone compared to morphine in chemotherapy-induced neuropathic pain.

PLoS ONE, 2014
Oxycodone is a μ-opioid receptor agonist, used for the treatment of a large variety of painful disorders. Several studies have reported that oxycodone is a more potent pain reliever than morphine, and that it improves the quality of life of patients ...
Karine Thibault, Bernard Calvino, Isabelle Rivals, Fabien Marchand, Sophie Dubacq, Stephen B McMahon, Sophie Pezet   +6 more
doaj   +1 more source

CYP2D6 genotype dependent oxycodone metabolism in postoperative patients. [PDF]

PLoS ONE, 2013
BACKGROUND: The impact of polymorphic cytochrome P450 CYP2D6 enzyme on oxycodone's metabolism and clinical efficacy is currently being discussed. However, there are only spare data from postoperative settings.
Ulrike M Stamer, Lan Zhang, Malte Book, Lutz E Lehmann, Frank Stuber, Frank Musshoff   +5 more
doaj   +1 more source

Challenges of Pain in Parkinson's Disease: Results from the OCEAN Study

Movement Disorders, EarlyView.
Abstract Background Pain is a common non‐motor symptom in Parkinson’s disease (PD) and is often associated to fluctuations. Objective The OpiCapone Effect on motor fluctuations and pAiN (OCEAN) study evaluated the effect of opicapone on fluctuation‐related pain when added to levodopa therapy in PD patients.
Kallol Ray Chaudhuri, Joaquim J. Ferreira, Angelo Antonini, Olivier Rascol, Monica M. Kurtis, Alexander Storch, José‐Francisco Rocha, Raquel Costa, Diogo Magalhães, Guillermo Castilla‐Fernández, Helena C. Brigas, Joerg Holenz, Per Odin, on behalf of the OCEAN study group   +13 more
wiley   +1 more source

Quality of life under oxycodone/naloxone, oxycodone, or morphine treatment for chronic low back pain in routine clinical practice

International Journal of General Medicine, 2016
Michael A Ueberall,1 Alice Eberhardt,2 Gerhard HH Mueller-Schwefe3 1Institute for Neurological Sciences, Nuernberg, Germany; 2Mundipharma GmbH, Limburg, Germany; 3Interdisciplinary Center for Pain and Palliative Care Medicine, Goeppingen, Germany ...
Ueberall MA, Eberhardt A, Mueller-Schwefe GHH   +2 more
doaj  

Cannabis‐Based Oil for Pain and Other Non‐Motor Symptoms in Parkinson's Disease: A Randomized Controlled Trial

Movement Disorders, EarlyView.
Abstract Background There is a lack of treatments for non‐motor symptoms (NMS) in Parkinson's disease (PD). Objective To assess the safety and effectiveness of an oral Cannabis sativa L. extract on pain and other NMS of PD. Methods This phase II, randomized, placebo‐controlled trial evaluated a formulation containing cannabidiol (CBD; 96 mg/ml) and Δ9 ...
Gabriel T. Kubota, Jacy B. Parmera, Matheus Deltreggia, Pedro N. Martins, Anna Letícia M. Alves, Ananda C.M. de Falcone, Ana Rosa Santana, Maria Alice P. Falcão, Mayara A. Dias, Larissa I. Moreira, Paulo C. de Fonseca Filho, Eberval G. Figueiredo, Egberto R. Barbosa, Rubens G. Cury, Daniel C. de Andrade   +14 more
wiley   +1 more source