Results 61 to 70 of about 28,231 (235)

Metabolic pathway of Oxycodone.

, 2014
Metabolic pathway of Oxycodone.
Masanori Toyoda (615518), Naomi Kiyota (562845), Yoshinori Imamura (615520), Takanobu Shimada (615519), Toru Mukohara (615521), Yutaka Fujiwara (615517), Naoko Chayahara (411772), Hironobu Minami (411771)   +7 more
core   +1 more source

Cannabis‐Based Oil for Pain and Other Non‐Motor Symptoms in Parkinson's Disease: A Randomized Controlled Trial

Movement Disorders, EarlyView.
Abstract Background There is a lack of treatments for non‐motor symptoms (NMS) in Parkinson's disease (PD). Objective To assess the safety and effectiveness of an oral Cannabis sativa L. extract on pain and other NMS of PD. Methods This phase II, randomized, placebo‐controlled trial evaluated a formulation containing cannabidiol (CBD; 96 mg/ml) and Δ9 ...
Gabriel T. Kubota, Jacy B. Parmera, Matheus Deltreggia, Pedro N. Martins, Anna Letícia M. Alves, Ananda C.M. de Falcone, Ana Rosa Santana, Maria Alice P. Falcão, Mayara A. Dias, Larissa I. Moreira, Paulo C. de Fonseca Filho, Eberval G. Figueiredo, Egberto R. Barbosa, Rubens G. Cury, Daniel C. de Andrade   +14 more
wiley   +1 more source

Oxycodone in Forensic Toxicology [Elektronisk resurs] : Analytical Strategies and Interpretation

, 2022
Oxycodone is a common finding in forensic casework and widely used as an analgetic. Oxycodone’s pharmacokinetic and pharmacodynamic properties make the interpretation of post mortem oxycodone blood concentrations complicated.
Kronstrand, Robert,, Gréen, Henrik,, Hasselstrøm, Jørgen Bo,, Jakobsson, Gerd,   +3 more
core   +2 more sources

Trough concentrations of oxycodone and its metabolites.

, 2014
Abbreviations: N, number of patients; Ratio (D3 to D1), the ratio of the geometric mean trough concentration of CR oxycodone plus aprepitant on day 3 to those of CR oxycodone alone on day 1; Ratio (D3 to D2), the ratio of the geometric mean trough ...
Masanori Toyoda (615518), Naomi Kiyota (562845), Yoshinori Imamura (615520), Takanobu Shimada (615519), Toru Mukohara (615521), Yutaka Fujiwara (615517), Naoko Chayahara (411772), Hironobu Minami (411771)   +7 more
core   +1 more source

Developing the Dopamine D3 Receptor (D3R) Antagonist, (R)‐VK4‐116, as a Non‐Opioid Medication for the Treatment of Opioid Use Disorder

Medicinal Research Reviews, EarlyView.
ABSTRACT Opioid use disorder (OUD) remains a major global health challenge, and currently approved treatments (methadone, buprenorphine, and naltrexone) are all opioid receptor‐targeting drugs with limitations in access, adherence, stigma, and use in polysubstance use disorders. Because the dopamine D3 receptor (D3R) is enriched in limbic brain regions
Chia‐Kuei Wu, Yu‐Chih Lin, Junfeng Huang, Bangwei Ding, Pramod Terse, Rahul Nandre, Haksong Jin, Molly Congdon, Kun Shen, Philip Sanderson, Gregory Tawa, Stephanie Mounaud, Marta De Santis, Donald Lo, Elizabeth A. Ottinger, Amy Hauck Newman   +15 more
wiley   +1 more source

Can early oral prolonged-release oxycodone, with or without naloxone reduce the duration of epidural analgesia after cystectomy? A three-arm, randomized, double-blind, placebo-controlled trial. [PDF]

, 2017
Thoracic epidural analgesia (TEA) enhances recovery after bowel surgery. Early postoperative prolonged-release oral formulation of oxycodone or oxycodone/naloxone is potentially useful as a second analgesic step to reduce the duration of TEA.
Kleeb, Bettina, Wüthrich, Patrick Yves, Fiona C. Burkhard, Patrick Y. Wuethrich, Löffel, Lukas M, Schneider, Marc Philipp, Marc P. Schneider, Furrer, Marc, Michele Curatolo, Lukas M. Löffel, Marc A. Furrer, Curatolo, Michele, Burkhard, Fiona C., Bettina Kleeb, Wuethrich PY, Burkhard FC, Furrer MA, Löffel LM, Curatolo M, Schneider MP, Kleeb B   +20 more
core   +3 more sources

The Dark Pyramid: Unpacking the Multidimensional Nature of the Dark Side of Leadership

British Journal of Management, EarlyView.
Abstract The dark side of leadership has been employed as an umbrella term to cover an array of concepts typically concerned with the dysfunctionality and/or toxicity of individual leaders. As the field of leadership studies moves towards ‘post‐heroic’ perspectives, we apply the same ontological positioning, adopting a ‘post‐villainous’ perspective in ...
Peter Stephenson, Richard Bolden, Morgen Witzel   +2 more
wiley   +1 more source

Protodesnitazene: The identification and tissue distribution of a new nitazene

Journal of Forensic Sciences, EarlyView.
Abstract Multiple new analogues from the 2‐benzyl benzimidazole or “nitazene” class of drugs have emerged on the drug market in recent years. Nitazenes are highly potent μ‐opioid receptor agonists that present a substantial public health concern due to their elevated risk of severe toxicity in overdose and their significant potential for misuse.
Andrew Griffiths, Nathan Milne, Michelle Johnston, Karen Blakey, Rogan Scott   +4 more
wiley   +1 more source

GC/MS determination of gabapentin in human plasma and vitreous humor and its application to forensic samples

Journal of Forensic Sciences, EarlyView.
Abstract Gabapentin (GBP) is widely prescribed off‐label, and cases of misuse, abuse, self‐medication, and intentional self‐harm have been reported. This study aimed to develop and validate a simple GC‐MS method for the determination of GBP in plasma and vitreous humor (VH) and to explore the relationship between concentrations in both matrices in ...
Pamela Cabarcos‐Fernández, Inés Sánchez‐Sellero, Iván Álvarez‐Freire, María Jesús Tabernero‐Duque, Ana María Bermejo‐Barrera   +4 more
wiley   +1 more source

Oxycodone self-administration and genetic background exert community-specific effects in the gut microbiome

Scientific Reports
The gut microbiome and genetic factors contribute to several opioid-related phenotypes in humans and animal models. Here, we examined the effects of genetic background and oxycodone self-administration on the gut microbiome in two genetically divergent ...
Eamonn P. Duffy, John D. Sterrett, Luanne H. Hale, Jonathan O. Ward, Laura M. Saba, Daniel N. Frank, Ryan K. Bachtell, Marissa A. Ehringer   +7 more
doaj   +1 more source