Results 81 to 90 of about 28,231 (235)
Asia-Pacific Journal of Clinical Oncology, EarlyView.Hydromorphone slow‐release tablet withdrawal from the Australian market altered opioid prescribing patterns in advanced cancer pain. Methadone use increased by nearly 50% and median doses doubled. There may be a need to tailor clinician training on safe and effective use of methadone and other opioids as appropriate. ABSTRACT Aim Ongoing disruptions to
Aaron K. Wong +7 more
wiley +1 more source
Journal of International Medical Research, 2020 Objectives This study presented the feasibility of oxycodone as the sole opioid for general anaesthesia in minor/moderate surgery. Methods In this prospective, observational, descriptive study, 62 patients were enrolled and received intravenous oxycodone
Fangping Bao +4 more
doaj +1 more source
Influence of Ethanol on Oxycodone-induced Respiratory Depression
, 2017 Background Respiratory depression is a potentially fatal complication of opioid use, which may be exacerbated by simultaneous ethanol intake.
Marieke Niesters +7 more
core +1 more source
Allergy, EarlyView.ABSTRACT These updated EAACI guidelines aim to standardize skin testing methodologies for both immediate and non‐immediate drug hypersensitivity reactions. For immediate reactions, the optimal testing window is 4–6 weeks post‐reaction; whereas beyond 6 months, false‐negative results increase.
Annick Barbaud +14 more
wiley +1 more source
Novel approaches for drug development against chronic primary pain: A systematic review
British Journal of Pharmacology, EarlyView.Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus +5 more
wiley +1 more source
, 2017 Jing-jing Nie,* Shen Sun, Shao-qiang Huang* Department of Anesthesiology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China *These authors contributed equally to this work Background: Oxycodone is a semisynthetic &mu ...
Huang SQ, Nie JJ, Sun S
core
Ethanol Reversal of Tolerance to the Antinociceptive Effects of Oxycodone and Hydrocodone [PDF]
, 2017 This study compared the development of tolerance and its reversal by ethanol of two orally-bioavailable prescription opioids, oxycodone and hydrocodone, to that of morphine. Oxycodone (s.c) was significantly more potent in the mouse tail withdrawal assay
Henderson, Graeme +9 more
core +1 more source
Cancer pain: current practice and emerging targets
British Journal of Pharmacology, EarlyView.Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye +5 more
wiley +1 more source
PKMζ alters oxycodone-taking in a dose- and sex-dependent manner
Addiction NeuroscienceOpioid use disorder involves disruptions to glutamate homeostasis and dendritic spine density in the reward system. PKMζ is an atypical isoform of protein kinase C that is expressed exclusively in neurons and plays a role in postsynaptic glutamate ...
Melissa C. Knouse +5 more
doaj +1 more source
Clinical and Translational Science, 2020 The objective of this study was to determine the effect of concomitant alcohol intake on the bioavailability of oxycodone from an oxycodone once‐daily (OOD) formulation and an oxycodone twice‐daily (OTD) formulation.
Nils Burger +4 more
doaj +1 more source