Results 101 to 110 of about 28,231 (235)

Oxycodone-induced tolerance to respiratory depression:reversal by ethanol, pregabalin and protein kinase C inhibition [PDF]

, 2018
BACKGROUND AND PURPOSE: Oxycodone, a prescription opioid, is a major drug of abuse, especially in the USA, and contributes significantly to opioid overdose deaths each year. Overdose deaths result primarily from respiratory depression.
Henderson, Graeme, Hill, Rob, William L Dewey, Graeme Henderson, Rob Hill, Eamonn Kelly, Dewey, William L, Kelly, Eamonn   +7 more
core   +1 more source

Implementation Evaluation of 41 Nurse‐Initiated Care Protocols in an Emergency Department: A Mixed Methods Study

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aim To evaluate the implementation outcomes of nurse‐initiated care protocols (NICP) in an emergency department (ED) using the RE‐AIM (reach, effectiveness, adoption, implementation, maintenance) framework. Design Convergent mixed‐methods implementation evaluation. Method The study was conducted between April 2025 and April 2026.
Julie Gawthorne, Andrea McCloughen, Kate Curtis   +2 more
wiley   +1 more source

Abuse Liability of Controlled-release Oxycodone Formulations [PDF]

, 2016
Controlled-release opioid formulations may have differential abuse liability profiles related to rates of drug delivery. In this double-blind, placebo-controlled, randomized, crossover study, the abuse liability of a single 40mg intact oral dose of ...
Rafat, Bijan
core   +1 more source

Trends in Dispensing of Opioids and Benzodiazepines Among Older Adults Admitted for an Acute Hip Fracture Between 2008 and 2024 in Ontario, Canada

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Introduction Opioids and benzodiazepines (BZDs) are commonly prescribed for managing pain, anxiety, and sleep‐related problems following a hip fracture. Both opioids and BZDs carry risks of persistent dependence, falls, and mortality with long‐term use. Despite these risks, Canada lacks standardized prescribing guidelines for older adults with
Anum Ali, Mina Tadrous, Chizaram Eje, Laleh Rashidian, Arrani Senthinathan, Cherry Chu, Kerry Kuluski, Sara J. T. Guilcher   +7 more
wiley   +1 more source

Electrochemical sensor based on mesoporous g-C3N4/N-CNO/gold nanoparticles for measuring oxycodone

Scientific Reports
Oxycodone, often used as an analgesic, is a potent opioid. While its effectiveness has been proven in the control of moderate to acute pain, excessive use of oxycodone imposes heart failure, heart palpitations, reduction of red blood cells, bone pain ...
Masoumeh Ghalkhani, Esmail Sohouli, Zeinab Saberi Dehkordi   +2 more
doaj   +1 more source

Sleep characteristics and self‐reported sleep quality in the oldest‐old: Results from a prospective longitudinal cohort study

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Little is known about the correlation between subjective perception and objective measures of sleep quality in particular in the oldest‐old. The aim of this study was to perform longitudinal home sleep monitoring in this age group, and to correlate results with self‐reported sleep quality.
Hugo Saner, Kevin Möri, Narayan Schütz, Philipp Buluschek, Tobias Nef   +4 more
wiley   +1 more source

SELF ADMINISTRATION OF OXYCODONE BY ADOLESCENT AND ADULT MICE AFFECTS STRIATAL NEUROTRANSMITTER RECEPTOR GENE EXPRESSION

, 2014
Illicit use of prescription opioid analgesics (e.g., oxycodone) in adolescence is a pressing public health issue. Our goal was to determine whether oxycodone self administration differentially affects striatal neurotransmitter receptor gene expression in
Mayer-Blackwell, B., Ott, J., Kreek, M. J., Ho, A., Schlussman, S. D., Butelman, E. R., Zhang, Y.   +6 more
core  

List of genes differentially regulated between vincristine-morphine vs. vincristine-oxycodone treated animals.

, 2014
Data are illustrated as follows: 1) Gene accession number; 2) Gene symbol; 3) Mean expression of the genes for the six different groups; 4) results of variance analysis between vincristine and control: p-value; 5) results of Student's t-test between ...
Bernard Calvino (533496), Fabien Marchand (533497), Stephen B. McMahon (108989), Sophie Pezet (533499), Karine Thibault (533495), Isabelle Rivals (144406), Sophie Dubacq (533498)   +6 more
core   +1 more source

“Buprenorphine doesn't hold me”: Neurochemical afterlives of state violence and the struggle for meaning in addiction treatment

Medical Anthropology Quarterly, EarlyView.
Abstract This paper analyzes two disparate experiences of buprenorphine, a medication for opioid addiction, in California. Within the context of the U.S. War on Drugs and after decades of criminalization, buprenorphine represents a shift toward outpatient medical treatment of opioid addiction, but it has been unequally distributed and experienced ...
Lauren Textor
wiley   +1 more source

Opioid Analgesic Exposure and Mental Health Disorders During Pregnancy: Exploring Their Independent and Joint Association With Adverse Birth Outcomes

Paediatric and Perinatal Epidemiology, EarlyView.
ABSTRACT Background Opioid use, depression and anxiety during pregnancy are independently associated with adverse perinatal outcomes, but their joint associations are less understood. Objective To examine the independent and joint associations, including interaction, of prenatal opioid analgesic exposure and maternal anxiety and depression with ...
Kristin K. Sznajder, Yi Wang, M. Luke Smith, Russell S. Kirby, Deborah B. Ehrenthal   +4 more
wiley   +1 more source