Results 91 to 100 of about 28,231 (235)

Ethanol Reversal of Oxycodone Tolerances [PDF]

, 2017
Oxycodone is a semi-synthetic opioid originally developed as a safer alternative to morphine. It is commonly prescribed for its pain-relieving effects, but has recently been implicated as a major underlying cause of the current opioid epidemic due to its
Jacob, Joanna C
core   +1 more source

In silico prediction of novel effective combinational treatment of chronic pain in individual patients: A joint white paper of the H2020 QSPainRelief consortium

British Journal of Pharmacology, EarlyView.
Abstract Opioids are prescribed widely for chronic pain despite well‐recognised risks and variable long‐term benefit, reflecting the lack of effective alternatives for many patients. Combination therapies offer a promising strategy to enhance efficacy whilst reducing side effects.
André Mouraux, Solenn Gousset, Beltrán Alvarez, Monica Baiula, Wouter Bakker, Andrea Bedini, Monir Bertayli, Divakar Budda, Robert Carr, Elisabetta Cuna, Óscar Díaz, Nina Donner, Jesús Giraldo, Geert‐Jan Groeneveld, Berfin Gülave, David Guydan, Hemme Hijma, Rafael Maldonado, Pedro Renault, Carlos Rinaudo, Jeroen Elaissaiss‐Schaap, Athan Spiros, Sara Stoeber, Petri Takkala, Daan van Valkengoed, Coen van Hasselt, Elizabeth (Liesbeth) C.M. de Lange   +26 more
wiley   +1 more source

Oxycodone ameliorates the inflammatory response induced by lipopolysaccharide in primary microglia

, 2018
Jishi Ye,1 Hong Yan,2 Zhongyuan Xia1 1Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, People’s Republic of China; 2Department of Anesthesiology, The Central Hospital of Wuhan, Tongji Medical College ...
Xia Z, Yan H, Ye J
core  

The c‐Src inhibitor eCF506 diminishes opioid tolerance and reduces β‐arrestin2 recruitment

British Journal of Pharmacology, EarlyView.
Morphine activation of μ receptors causes tolerance through c‐Src activation and β‐arrestin2 recruitment. c‐Src inhibition or degradation reduces β‐arrestin2 recruitment, μ receptor endocytosis, while causing receptor upregulation, all likely contributing to reduced morphine tolerance.
Samuel Singleton, Fraser Nunn, Erika Lace, Álvaro Lorente‐Macías, Rachel Toth, Asier Unciti‐Broceta, Tim G. Hales   +6 more
wiley   +1 more source

Adding nefopam to oxycodone-based patient-controlled analgesia provides noninferior analgesia with opioid sparing after laparoscopic surgery

Scientific Reports
To evaluate the analgesic efficacy and opioid-sparing effect of two different doses of nefopam combined with oxycodone in intravenous patient-controlled analgesia (IV PCA) compared with oxycodone alone after laparoscopic abdominal surgery. In this single-
Juyeon Oh, Eun-Ju Lee, Kyung Mi Kim, Eun-Kyung Lee, Ji-Yeon Bang, Byung-Moon Choi, Gyu-Jeong Noh   +6 more
doaj   +1 more source

Analgesic efficacy, adverse effects, and safety of oxycodone administered as continuous intravenous infusion in patients after total hip arthroplasty

, 2017
Bogumił Olczak,1 Grzegorz Kowalski,1,2 Wojciech Leppert,2 Iwona Zaporowska-Stachowiak,3 Katarzyna Wieczorowska-Tobis2 1Department of Anesthesiology, Józef Struś Multiprofile Municipal Hospital, 2Department of Palliative Medicine, Poznan University
Kowalski G, Leppert W, Olczak B, Zaporowska-Stachowiak I, Wieczorowska-Tobis K   +4 more
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Real‐world diagnosis and treatment of individuals with migraine in the United States: The Migraine Insights in Diagnosis and Treatment (MIND) study

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective The objective of this study was to describe the real‐world diagnosis and treatment patterns of individuals newly diagnosed with migraine in the United States (US). Background Over 10% of adults in the US are living with migraine.
Fred Cohen, Vincent Martin, Avani Patel, Shelby L. Corman, Katie B. Tellor, Meghan Fajardo, D. Cortney Hayflinger, Simon Dagenais   +7 more
wiley   +1 more source

Medical emergency response related to MedicAtion InciDents (MERRMAID): a case series and lessons to improve medication safety

Internal Medicine Journal, EarlyView.
Abstract Background Evidence suggests that some medical emergencies in hospital are associated with preventable medication errors or adverse reactions. Aim The purpose of this case series was to investigate and describe the proportion of Medical Emergency Response Team (MERT) activations that are medication‐related, the degree of preventability and ...
Ian Coombes, Amelia Anderson, Fiona Coombes, Gloria Wong, Daisy Lindsay, John Gowardman, Peter Donovan, Sinead Carmichael, Bianca Levkovich, Karen Davies   +9 more
wiley   +1 more source

Gender Affects the Median Effective Dose and 95% Effective Dose of Oxycodone for Blunting the Hemodynamic Response to Tracheal Intubation in Narcotic-Naïve Adult Patients

Chinese Medical Journal, 2018
Background: Intravenous (IV) oxycodone has been used at induction to prevent an intubation reaction. The aims of the current study were to calculate the median effective dose (ED50) and the 95% effective dose (ED95) of an IV bolus of oxycodone that ...
Xian-Hui Kang, Fang-Ping Bao, Hong-Gang Zhang, Dan-Jun Yu, Ke Ha, Qing Xie, Sheng-Mei Zhu   +6 more
doaj   +1 more source

Effect of Oxycodone-Based Multimodal Analgesia on Visceral Pain After Major Laparoscopic Gastrointestinal Surgery: A Randomised, Double-Blind, Controlled Trial [PDF]

Guo-Wang Yang,1,2 Hao Cheng,1,2 Xiao-Yang Song,3 Yu-Fan Yang,1,2 Hong Liu,4 Fu-Hai Ji,1,2 Ke Peng1,2 1Department of Anaesthesiology, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People’s Republic of China; 2Institute of ...
Song XY, Liu H, Ji FH, Yang GW, Yang YF, Cheng H, Peng K   +6 more
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