Results 121 to 130 of about 28,231 (235)

Opioid Use and Family Members' Experiences of Opioids in Paediatric Cancer Pain Management: An Integrative Review

Scandinavian Journal of Caring Sciences, Volume 40, Issue 4, December 2026.
ABSTRACT Aim To analyse the use of opioids in children with cancer and the experiences of their family members regarding opioids used in pain management to improve family nursing. Design An integrative review. Methods A systematic literature search was carried out in four databases (CINAHL, MEDLINE, PsycInfo and Scopus) in August 2023, and was ...
Noora Puusa, Eeva Harju, Maija‐Liisa Kalliomäki, Elina Haavisto   +3 more
wiley   +1 more source

Advances in the Design and Functionality of a Compact Multi‐Reflecting Time‐of‐Flight Mass Spectrometer

Rapid Communications in Mass Spectrometry, Volume 40, Issue 22, 30 November 2026.
ABSTRACT Rationale High‐resolution mass spectrometry is routinely used for the analysis of complex samples in pharmaceutical, environmental, and omics related studies. Such applications demand instrumentation to be capable of combining sub‐ppm mass accuracy, high resolving power, rapid full m/z range acquisition over a wide dynamic range.
Jason Wildgoose, Samantha Ferries, Lee A. Gethings, Matthew E. Daly, Martin E. Palmer, Richard Lock, Johannes P. C. Vissers, James I. Langridge   +7 more
wiley   +1 more source

Analgesic efficacy, safety, and tolerability of a long-acting abuse-deterrent formulation of oxycodone for moderate-to-severe chronic low back pain in subjects successfully switched from immediate-release oxycodone

Journal of Pain Research, 2018
John Markman,1 Diana S Meske,2 Ernest A Kopecky,2 Ben Vaughn,3 Melinda L O’Connor,2 Steven D Passik2 1Department of Neurosurgery, Translational Pain Research Program, University of Rochester, Rochester, NY, USA; 2Collegium Pharmaceutical Inc.,
Markman J, Meske DS, Kopecky EA, Vaughn B, O'Connor ML, Passik SD   +5 more
doaj  

Development of a nalmefene formulation suitable for a community‐use auto‐injector

British Journal of Clinical Pharmacology, Volume 92, Issue 11, Page 3914-3925, November 2026.
Aim Time to onset of reversal is critical when treating opioid‐induced respiratory depression and hypoxia. This study aimed to develop a formulation of the opioid antagonist nalmefene with an increased absorption rate and reduced time to onset of reversal following intramuscular administration. Methods Several absorption enhancers were screened in rats,
Alessandra Cipriano, Manjunath S. Shet, Hugh Huang, Ronnie Ortiz, Garth T. Whiteside, Glen Apseloff, Stephen C. Harris   +6 more
wiley   +1 more source

Determination of the MEC90 of Oxycodone for Preventing Perioperative Shivering in Pregnant Patients Undergoing Caesarean Delivery with Neuraxial Anaesthesia: A Biased-Coin up-and-Down Sequential Allocation Trial [PDF]

Xinlei Lu,1,* Kaiyu Chen,1,2,* Ye Xuan,1,2 Mengting Shen,1,2 Weiping Lei,1 Yaqin Huang,1 Jianliang Sun1 1Department of Anaesthesiology, Affiliated Hangzhou First People’s Hospital, School of Medicine, Westlake University, Hangzhou, People’s ...
Shen M, Chen K, Huang Y, Lu X, Lei W, Xuan Y, Sun J   +6 more
core  

Cannabidiol reduces oxycodone self-administration while preserving its analgesic efficacy in a rat model of neuropathic pain

Scientific Reports
Prescription opioid misuse is a significant public health concern among individuals with chronic pain. Treating severe pain often requires high doses of opioids, increasing the risk of developing an opioid use disorder.
Adriaan W. Bruijnzeel, Azin Behnood-Rod, Ranjithkumar Chellian, Wendi Malphurs, Robert M. Caudle, Marcelo Febo, Barry Setlow, Niall P. Murphy, John K. Neubert   +8 more
doaj   +1 more source

Monitoring Injected Drug Use in Greece Through Syringe Residue Analysis: A Multicity Study Within the ESCAPE Network

Drug Testing and Analysis, Volume 18, Issue 11, Page 1407-1417, November 2026.
A total of 2121 used syringes were analyzed in Athens, Thessaloniki, and Patras between 2022 and 2024. Distinct drug‐use patterns were observed across the three cities. Benzodiazepines, pregabalin, methadone, and fentanyl were increasingly detected in 2024.
Christina Matiaki, Anastasios Trakakis, Athanasios Theocharis, Chara Parpala, Chara Kotsailidou, Alexandros Psarianos, Emmanouil Chatzichristofis, Eleni Zagelidu, Panagiota Roussou, Nikolaos Raikos, Orthodoxia Mastrogianni   +10 more
wiley   +1 more source

Inbred rat heredity and sex affect oral oxycodone self-administration and augmented intake in long sessions: correlations with anxiety and novelty-seeking.

PLoS ONE
Oxycodone abuse frequently begins with prescription oral oxycodone, yet vulnerability factors (e.g. sex, genetics) determining abuse are largely undefined.
Burt M Sharp, Shuangying Leng, Jun Huang, Caroline Jones, Robert W Williams, Hao Chen   +5 more
doaj   +1 more source

Postoperative Pain Treatment After Pancreatic Surgery: A Systematic Review With Meta‐Analyses and Trial Sequential Analyses

European Journal of Pain, Volume 30, Issue 10, November 2026.
ABSTRACT Background Major pancreatic surgery is associated with significant postoperative pain that impairs early mobilisation and recovery. ERAS guidelines for pancreaticoduodenectomy recommend multimodal opioid‐sparing analgesia, with a strong recommendation for epidural analgesia and continuous wound infiltration as an alternative.
Caroline D. Lassen, Fatieh Yousef, Eske Kvanner Aasvang, Waqas Farooqui, Sermed Ellebæk Nicolae, Anja Geisler   +5 more
wiley   +1 more source

Modification of genes regulating GABA receptor activity expression after oxycodone treatment.

, 2014
Data are illustrated as follows: 1) Mean expression value for all groups; 2) Statistical analysis: results of variance analysis between vincristine and control: p-value and expression difference (vincristine – control); results of Student's t test ...
Bernard Calvino (533496), Fabien Marchand (533497), Stephen B. McMahon (108989), Sophie Pezet (533499), Karine Thibault (533495), Isabelle Rivals (144406), Sophie Dubacq (533498)   +6 more
core   +1 more source