Results 31 to 40 of about 28,231 (235)

Ketogenic diet enhances the effects of oxycodone in mice

Scientific Reports, 2023
Opioids have been used to manage pain for thousands of years, but they have significant potential for abuse. Prescription opioids, like oxycodone, are associated with 32% of overdoses, that have reached a total of 75,673 deaths in 2021. A major challenge
R. Trinko, D. M. Diaz, E. Foscue, S. L. Thompson, J. R. Taylor, R. J. DiLeone   +5 more
doaj   +1 more source

Attenuation of opioid tolerance by ETB receptor agonist, IRL-1620, is independent of an accompanied decrease in nerve growth factor in mice

Heliyon, 2017
Aim: ETA receptor antagonists reverse opioid tolerance but the involvement of ETB receptors is unknown. In morphine or oxycodone tolerant mice we investigated (1) the effect of ETB receptor agonist, IRL-1620, on analgesic tolerance; (2) changes in ...
Shruti Gulati, Seema Briyal, Shantel Jones, Shaifali Bhalla, Anil Gulati   +4 more
doaj   +1 more source

Oxycodone-Mediated Activation of the Mu Opioid Receptor Reduces Whole Brain Functional Connectivity in Mice

, 2019
Oxycodone is a potent medicinal opioid analgesic to treat pain. It is also addictive and a main cause for the current opioid crisis. At present, the impact of oxycodone on coordinated brain network activities, and contribution of the mu opioid receptor ...
Brigitte L. Kieffer (264484), Brigitte L. Kieffer, Jai Puneet Singh (6941705), Md Taufiq Nasseef, Praveen Kulkarni, Michael McNicholas (5401172), Da Woon Park, Weiya Ma (1330083), Michael McNicholas, Weiya Ma, Md Taufiq Nasseef (6941702), Aliza T. Ehrlich (6941708), Aliza T. Ehrlich, Emmanuel Darcq (741574), Jai Puneet Singh, Da Woon Park (6941711), Praveen Kulkarni (433608), Emmanuel Darcq   +17 more
core   +1 more source

Sex and genetic background influence intravenous oxycodone self-administration in the hybrid rat diversity panel

Frontiers in Psychiatry
Opioid Use Disorder (OUD) is an ongoing worldwide public health concern. Genetic factors contribute to multiple OUD-related phenotypes, such as opioid-induced analgesia, initiation of opioid use, and opioid dependence.
Eamonn P. Duffy, Eamonn P. Duffy, Jonathan O. Ward, Luanne H. Hale, Kyle T. Brown, Andrew J. Kwilasz, Erika A. Mehrhoff, Erika A. Mehrhoff, Laura M. Saba, Marissa A. Ehringer, Marissa A. Ehringer, Ryan K. Bachtell, Ryan K. Bachtell   +12 more
doaj   +1 more source

Oxycodone-induced dopaminergic and respiratory effects are modulated by deep brain stimulation

, 2023
Introduction: Opioids are the leading cause of overdose death in the United States, accounting for almost 70,000 deaths in 2020. Deep brain stimulation (DBS) is a promising new treatment for substance use disorders.
Yoonbae Oh (3325359), Michael Berk (343706), Charles D Blaha (13386462), Tyler S Oesterle (16559508), Jason Yuen (4870732), Susannah J Tye (13356990), Aaron E Rusheen (13386453), Jee Hyun Kim (8573304), Abbas Kouzani (13079637), Osama A Abulseoud (16559505), Kevin E Bennet (13429830), Kendall H Lee (13386465), Hojin Shin (3325350), Abhinav Goyal (9901207)   +13 more
core  

Pharmacokinetics of oxycodone/naloxone and its metabolites in patients with end-stage renal disease during and between haemodialysis sessions [PDF]

, 2019
The pharmacokinetics of oxycodone in patients with end-stage renal disease (ESRD) requiring haemodialysis are largely unknown. Therefore, we investigated the pharmacokinetics of oxycodone/naloxone prolonged release and their metabolites in patients with ...
Haschke, Manuel Martin, Liechti, Matthias E, Schmid, Yasmin, Dickenmann, Michael, Jehle, Andreas W., Leuppi-Taegtmeyer, Anne, Amico, Patricia, Lenherr, Christoph, Meyer Zu Schwabedissen, Henriette E, Liechti, Matthias E., Krähenbühl, Stephan, Haschke, Manuel, Hammann, Felix, Jehle, Andreas W, Duthaler, Urs, Kalbermatter, Stefan, Meyer Zu Schwabedissen, Henriette E., Leuppi-Taegtmeyer A, Lenherr C, Hammann F, Amico P, Krähenbühl S, Meyer Zu Schwabedissen HE, Duthaler U, Jehle AW, Schmid Y, Dickenmann M, Kalbermatter S, Haschke M, Liechti ME   +29 more
core   +1 more source

Opioid Prescription Trends by Otolaryngologists for Medicare Part D Patients [PDF]

Laryngoscope Investig Otolaryngol
Between 2013 and 2024, ENT opioid prescriptions reached a nadir in 2020 with a post pandemic rebound. ABSTRACT Objective To characterize longitudinal trends in opioid prescription patterns among otolaryngologists in the Medicare Part D population spanning the COVID‐19 pandemic, including overall prescribing volume, drug‐type composition, and geographic
Wang L, Peterson J, Zhang J, Sriram N, Smith S, Wang J.   +5 more
europepmc   +2 more sources

Oxycodone or oxycodone plus paracetamol for acute postoperative pain in adults [PDF]

, 2010
In this short communication we wanted to find out what is the analgesic effect of single dose oral oxycodone, with or without the addition of paracetamol, for adults with postoperative pain?
Chan, Raymond
core  

Epidural Oxycodone for Acute Pain

, 2022
Epidural analgesia is commonly used in labour analgesia and in postoperative pain after major surgery. It is highly effective in severe acute pain, has minimal effects on foetus and newborn, may reduce postoperative complications, and enhance patient ...
Merja Kokki, Hannu Kokki, Piirainen, Panu, Kokki, Hannu, Kokki, Merja, Panu Piirainen   +5 more
core   +1 more source

Initiation of Gabapentin with Opioids and Risk of Respiratory Cardiovascular and Opioid‐Related Adverse Events Following Surgery for Breast Cancer

Clinical Pharmacology &Therapeutics, EarlyView.
Pain is a key determinant of quality‐of‐life following breast cancer surgery, the most common cancer operation in the United States. Gabapentinoids are frequently prescribed for pain management, yet their respiratory, cardiovascular, and opioid‐related adverse effects remain unclear.
Jyun‐Heng Lai, Anton L V Avanceña, Juan P Cata, Jamie C. Barner, Sharon H. Giordano, Chanhyun Park, Hui Zhao, Kirk E. Evoy, John K. Lin, Jennifer C. Spencer, Mariana Chavez‐MacGregor, Kelly K. Hunt, Kerollos Nashat Wanis   +12 more
wiley   +1 more source