Results 11 to 20 of about 22,050 (201)

An observational cohort study comparing ibuprofen and oxycodone in children with fractures.

PLoS ONE, 2021
ObjectiveTo compare the effectiveness and safety of prescribing ibuprofen and oxycodone for at-home management of children's fracture pain.MethodsA prospective observational cohort was conducted at the Stollery Children's Hospital pediatric emergency ...
Samina Ali, Robin Manaloor, David W Johnson, Rhonda J Rosychuk, Sylvie LeMay, Bruce Carleton, Patrick J McGrath, Amy L Drendel, Pediatric Emergency Research Canada   +8 more
doaj   +1 more source

Contemporary management of pain in cirrhosis: Toward precision therapy for pain

Hepatology, EarlyView., 2022
Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman, Neehar Parikh, Dan J. Clauw, David A. Williams, Elliot B. Tapper   +4 more
wiley   +1 more source

Effects of aprepitant on the pharmacokinetics of controlled-release oral oxycodone in cancer patients. [PDF]

PLoS ONE, 2014
PURPOSE: Oxycodone is a µ-opioid receptor agonist widely used in the treatment of cancer pain. The predominant metabolic pathway of oxycodone is CYP3A4-mediated N-demethylation to noroxycodone, while a minor proportion undergoes 3-O-demethylation to ...
Yutaka Fujiwara, Masanori Toyoda, Naoko Chayahara, Naomi Kiyota, Takanobu Shimada, Yoshinori Imamura, Toru Mukohara, Hironobu Minami   +7 more
doaj   +1 more source

Postmortem Metabolomics Reveal Acylcarnitines as Potential Biomarkers for Fatal Oxycodone-Related Intoxication

Metabolites, 2022
Postmortem metabolomics has recently been suggested as a potential tool for discovering new biological markers able to assist in death investigations. Interpretation of oxycodone concentrations in postmortem cases is complicated, as oxycodone tolerance ...
Albert Elmsjö, Carl Söderberg, Gerd Jakobsson, Henrik Green, Robert Kronstrand   +4 more
doaj   +1 more source

S-ketamine in patient-controlled analgesia reduces opioid consumption in a dose-dependent manner after major lumbar fusion surgery: A randomized, double-blind, placebo-controlled clinical trial.

PLoS ONE, 2021
BackgroundSpinal fusion surgery causes severe pain. Strong opioids, commonly used as postoperative analgesics, may have unwanted side effects. S-ketamine may be an effective analgesic adjuvant in opioid patient-controlled analgesia (PCA).
Elina C V Brinck, Taru Virtanen, Sanna Mäkelä, Venla Soini, Ville-Veikko Hynninen, Jukka Mulo, Urmas Savolainen, Juho Rantakokko, Kreu Maisniemi, Antti Liukas, Klaus T Olkkola, Vesa Kontinen, Pekka Tarkkila, Marko Peltoniemi, Teijo I Saari   +14 more
doaj   +1 more source

Oxycodone intravenous for acute pain management in modified radical mastectomy

Bali Journal of Anesthesiology, 2020
Oxycodone hydrochloride is a semisynthetic opioid which extracted from the baine plant, with a similar analgesic potency compared with morphine. Although oxycodone was introduced in 1917, the global use of oxycodone in acute postoperative management ...
Tjokorda Gde Agung Senapathi, I Putu Pramana Suarjaya, I Wayan Aryabiantara, Adinda Putra Pradhana, Amalia Margaretha Berhimpon   +4 more
doaj   +1 more source

Suvorexant, an FDA-approved dual orexin receptor antagonist, reduces oxycodone self-administration and conditioned reinstatement in male and female rats

Frontiers in Pharmacology, 2023
Background: The Department of Health and Human Services reports that prescription pain reliever (e.g., oxycodone) misuse was initiated by 4,400 Americans each day in 2019.
Jessica M. Illenberger, Francisco J. Flores-Ramirez, Alessandra Matzeu, Barbara J. Mason, Rémi Martin-Fardon   +4 more
doaj   +1 more source

Intravenous Oxycodone Versus Other Intravenous Strong Opioids for Acute Postoperative Pain Control: A Systematic Review of Randomized Controlled Trials

Pain and Therapy, 2019
Introduction Optimal pain management is crucial to the postoperative recovery process. We aimed to evaluate the efficacy and safety of intravenous oxycodone with intravenous fentanyl, morphine, sufentanil, pethidine, and hydromorphone for acute ...
Milton Raff, Anissa Belbachir, Salah El-Tallawy, Kok Yuen Ho, Eric Nagtalon, Amar Salti, Jeong-Hwa Seo, Aida Rosita Tantri, Hongwei Wang, Tianlong Wang, Kristal Cielo Buemio, Consuelo Gutierrez, Yacine Hadjiat   +12 more
doaj   +1 more source

Oxycodone in mastectomy surgery

Bali Journal of Anesthesiology, 2020
The pharmacological effects of oxycodone and morphine are close. The analgesic potency between oxycodone and morphine is presumed to have a 1:1 ratio. Fentanyl-to-morphine ratio was 1:100. The plasma levels of oxycodone are more active than morphine. The
Putu Pramana Suarjaya, Cynthia Dewi Sinardja, Aninda Tanggono   +2 more
doaj   +1 more source

Ketogenic diet enhances the effects of oxycodone in mice

Scientific Reports, 2023
Opioids have been used to manage pain for thousands of years, but they have significant potential for abuse. Prescription opioids, like oxycodone, are associated with 32% of overdoses, that have reached a total of 75,673 deaths in 2021. A major challenge
R. Trinko, D. M. Diaz, E. Foscue, S. L. Thompson, J. R. Taylor, R. J. DiLeone   +5 more
doaj   +1 more source