Results 11 to 20 of about 28,231 (235)

CYP2D6 genotype dependent oxycodone metabolism in postoperative patients. [PDF]

PLoS ONE, 2013
BACKGROUND: The impact of polymorphic cytochrome P450 CYP2D6 enzyme on oxycodone's metabolism and clinical efficacy is currently being discussed. However, there are only spare data from postoperative settings.
Ulrike M Stamer, Lan Zhang, Malte Book, Lutz E Lehmann, Frank Stuber, Frank Musshoff   +5 more
doaj   +4 more sources

Quality of life under oxycodone/naloxone, oxycodone, or morphine treatment for chronic low back pain in routine clinical practice

International Journal of General Medicine, 2016
Michael A Ueberall,1 Alice Eberhardt,2 Gerhard HH Mueller-Schwefe3 1Institute for Neurological Sciences, Nuernberg, Germany; 2Mundipharma GmbH, Limburg, Germany; 3Interdisciplinary Center for Pain and Palliative Care Medicine, Goeppingen, Germany ...
Ueberall MA, Eberhardt A, Mueller-Schwefe GHH   +2 more
doaj   +1 more source

Estrous cycle dependent expression of oxycodone conditioned reward in rats

Scientific Reports, 2023
Oxycodone is one of the most widely prescribed and misused opioid painkillers in the United States. Evidence suggests that biological sex and hormonal status can impact drug reward in humans and rodents, but the extent to which these factors can ...
Jessica A. Babb, Nicholas J. Constantino, Gary B. Kaplan, Elena H. Chartoff   +3 more
doaj   +2 more sources

Analgesic efficacy and safety of epidural oxycodone in patients undergoing total hip arthroplasty: a pilot study

Journal of Pain Research, 2017
Bogumił Olczak,1 Grzegorz Kowalski,1,2 Wojciech Leppert,2 Agnieszka Bienert,3 Artur Teżyk,4 Michał Adamski,1 Stanisław Rzymski,1 Katarzyna Wieczorowska-Tobis2 1Department of Anaesthesiology, Józef Struś Multiprofile Municipal Hospital, Poznań ...
Olczak B, Kowalski G, Leppert W, Bienert A, Teżyk A, Adamski M, Rzymski S, Wieczorowska-Tobis K   +7 more
doaj   +1 more source

Oxycodone regulates incision-induced activation of neurotrophic factors and receptors in an acute post-surgery pain rat model

Journal of Pain Research, 2018
Baowen Liu, Yi Liu, Ningbo Li, Jin Zhang, Xianwei Zhang Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Background: Oxycodone, which is one of the most commonly used ...
Liu BW, Liu Y, Li NB, Zhang J, Zhang XW
doaj   +1 more source

Tramadol Co-Administration with Oxycodone or Hydrocodone Increases Opioid Burden without Improving Postoperative Pain Control. [PDF]

Clin Pharmacol Ther
Tramadol is frequently co‐prescribed with oxycodone or hydrocodone after surgery under the assumption that its dual mechanism of action provides an opioid‐sparing benefit. However, evidence supporting this practice is limited and inconsistent. We conducted a secondary analysis of the multicenter IGNITE ADOPT‐PGx pragmatic trial of patients undergoing ...
Nahid NA, Soliman AI, Baye JF, Petry NJ, Gray CF, Myers RA, Elwood EN, Harris EC, Chakraborty H, Volpi S, Rider R, Dexter PR, Peterson JF, Skaar TC, Parvataneni HK, Cavallari LH, Johnson JA, IGNITE Pragmatic Trial Network Investigators.   +17 more
europepmc   +2 more sources

Population pharmacokinetics of oxycodone and metabolites in patients with cancer‐related pain [PDF]

, 2021
Oxycodone is frequently used for treating cancer‐related pain, while not much is known about the factors that influence treatment outcomes in these patients.
A.W. (Astrid) Oosten, B.C. (Bram) Agema, C.C.D. (Karin) van der Rijt, W.J.R. (Wim) Rietdijk, B.C.P. (Birgit) Koch, A.H.J. (Ron) Mathijssen, S.L.W. (Stijn) Koolen, S.D.T. (Sebastiaan) Sassen, Sebastiaan D.T. Sassen, Sassen, Sebastiaan D.T.; id_orcid, Koolen, Stijn L.W., Carin C.D. van der Rijt, Mathijssen, Ron H.J.; id_orcid, Birgit C.P. Koch, van der Rijt, Carin C.D.; id_orcid, Bram C. Agema, Rietdijk, Wim J.R., Astrid W. Oosten, Agema, Bram C., Oosten, Astrid W.; id_orcid, Ron H.J. Mathijssen, Wim J.R. Rietdijk, Koch, Birgit C.P., Stijn L.W. Koolen   +23 more
core   +3 more sources

Haemodynamic and Respiratory Effects of Dexmedetomidine as an Adjuvant to Oxycodone Patient-Controlled Analgesia After Lumbar Spinal Fusion: A Post Hoc Analysis of the DoseRespDex Randomised Controlled Trial. [PDF]

Acta Anaesthesiol Scand
ABSTRACT Purpose Dexmedetomidine has been studied as an adjunct to opioid patient‐controlled analgesia (PCA) because of its opioid‐sparing properties and limited respiratory depression. However, potential dose‐dependent haemodynamic effects should be considered, and data on dexmedetomidine administered via PCA remain limited.
Mäkelä S, Saari TI, Löyttyniemi E, Aantaa R, Liukas A, Uusalo P.   +5 more
europepmc   +2 more sources

Contemporary management of pain in cirrhosis: Toward precision therapy for pain

Hepatology, EarlyView., 2022
Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman, Neehar Parikh, Dan J. Clauw, David A. Williams, Elliot B. Tapper   +4 more
wiley   +1 more source

Postmortem Metabolomics Reveal Acylcarnitines as Potential Biomarkers for Fatal Oxycodone-Related Intoxication

Metabolites, 2022
Postmortem metabolomics has recently been suggested as a potential tool for discovering new biological markers able to assist in death investigations. Interpretation of oxycodone concentrations in postmortem cases is complicated, as oxycodone tolerance ...
Albert Elmsjö, Carl Söderberg, Gerd Jakobsson, Henrik Green, Robert Kronstrand   +4 more
doaj   +1 more source