Results 1 to 10 of about 21,993 (144)
Journal of Pain and Symptom Management, 2005 Oxycodone has been in clinical use since 1917. Parenteral oxycodone was used mainly for the treatment of acute postoperative pain whereas combinations, for example, oxycodone and acetaminophen, were used for moderate pain. Since the introduction of controlled-release oxycodone, it has been used to manage cancer-related pain and chronic non-cancer ...
Eija Anneli Kalso
exaly +3 more sources
Oxycodone self-administration and genetic background exert community-specific effects in the gut microbiome [PDF]
Scientific ReportsThe gut microbiome and genetic factors contribute to several opioid-related phenotypes in humans and animal models. Here, we examined the effects of genetic background and oxycodone self-administration on the gut microbiome in two genetically divergent ...
Eamonn P. Duffy +7 more
doaj +2 more sources
Effects of an Oxycodone Conjugate Vaccine on Oxycodone Self-Administration and Oxycodone-Induced Brain Gene Expression in Rats [PDF]
PLoS ONE, 2014 Prescription opioid abuse is an increasing public health concern in the USA. A vaccine comprising a hapten (OXY) conjugated to the carrier protein keyhole limpet hemocyanin (OXY-KLH) has been shown to attenuate the antinociceptive effects of oxycodone ...
Elena Chartoff +2 more
exaly +2 more sources
Cannabidiol reduces oxycodone self-administration while preserving its analgesic efficacy in a rat model of neuropathic pain [PDF]
Scientific ReportsPrescription opioid misuse is a significant public health concern among individuals with chronic pain. Treating severe pain often requires high doses of opioids, increasing the risk of developing an opioid use disorder.
Adriaan W. Bruijnzeel +8 more
doaj +2 more sources
Frontiers in Behavioral Neuroscience, 2021 Relapse is a major obstacle to curb the ongoing epidemic of prescription opioid abuse. We and others previously demonstrated that oxycodone seeking in adult rats progressively increases after abstinence from oxycodone self-administration (incubation of ...
Rachel D. Altshuler +2 more
doaj +1 more source
Pharmaceutics, 2021 Oxycodone is a widely used opioid for the management of chronic pain. Analgesic effects observed following the administration of oxycodone are mediated mostly by agonistic effects on the μ-opioid receptor.
Malavika Deodhar +2 more
doaj +1 more source
A quantitative analytical investigation on the oxycodone side effects listed in recent clinical trials [PDF]
European Journal of Translational and Clinical Medicine, 2023 Background: Oxycodone is a semi-synthetic narcotic analgesic medication with numerous side effects. Patients who use oxycodone may have one or more side effects depending on their clinical status and/or other factors.
Farshad Ghassemi Toosi +1 more
doaj +1 more source
Scientific Reports, 2023 Opioid-alcohol polysubstance use is prevalent and worsens treatment outcomes. Here we assessed whether co-consumption of oxycodone and alcohol influence the intake of one another, demand for oxycodone, and the neurocircuitry underlying cue-primed ...
Courtney S. Wilkinson +7 more
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Frontiers in Behavioral Neuroscience, 2023 IntroductionThe increasing misuse of both prescription and illicit opioids has culminated in a national healthcare crisis in the United States. Oxycodone is among the most widely prescribed and misused opioid pain relievers and has been associated with a
Nicole M. Hinds +7 more
doaj +1 more source
The effect of icotinib or apatinib on the pharmacokinetic profile of oxycodone in rats and the underlying mechanism [PDF]
PeerJ, 2023 This study aimed to investigate the interactions between icotinib/apatinib and oxycodone in rats and to unveil the underlying mechanism. An ultra-performance liquid chromatography–tandem mass spectrometry (UPLC-MS/MS) method was developed and validated ...
Qi Zhou +7 more
doaj +2 more sources