Effects of an oxycodone conjugate vaccine on oxycodone self-administration and oxycodone-induced brain gene expression in rats. [PDF]
PLoS ONE, 2014 Prescription opioid abuse is an increasing public health concern in the USA. A vaccine comprising a hapten (OXY) conjugated to the carrier protein keyhole limpet hemocyanin (OXY-KLH) has been shown to attenuate the antinociceptive effects of oxycodone ...
Marco Pravetoni +5 more
doaj +4 more sources
Effects of sex and estrous cycle on intravenous oxycodone self-administration and the reinstatement of oxycodone-seeking behavior in rats [PDF]
Frontiers in Behavioral Neuroscience, 2023 IntroductionThe increasing misuse of both prescription and illicit opioids has culminated in a national healthcare crisis in the United States. Oxycodone is among the most widely prescribed and misused opioid pain relievers and has been associated with a
Nicole M. Hinds +7 more
doaj +2 more sources
Genetic modulation of oxycodone self-administration trajectories: from initiation to escalating burst patterns [PDF]
Frontiers in Behavioral NeuroscienceIntroductionOpioid Use Disorder (OUD) remains a prominent threat to global health. Genetic background influences the susceptibility of developing OUD, although specific genetic factors remain elusive.
Caleb I. Hodges +10 more
doaj +2 more sources
Frontiers in Behavioral Neuroscience, 2021 Relapse is a major obstacle to curb the ongoing epidemic of prescription opioid abuse. We and others previously demonstrated that oxycodone seeking in adult rats progressively increases after abstinence from oxycodone self-administration (incubation of ...
Rachel D. Altshuler +2 more
doaj +1 more source
A quantitative analytical investigation on the oxycodone side effects listed in recent clinical trials [PDF]
European Journal of Translational and Clinical Medicine, 2023 Background: Oxycodone is a semi-synthetic narcotic analgesic medication with numerous side effects. Patients who use oxycodone may have one or more side effects depending on their clinical status and/or other factors.
Farshad Ghassemi Toosi +1 more
doaj +1 more source
Pharmaceutics, 2021 Oxycodone is a widely used opioid for the management of chronic pain. Analgesic effects observed following the administration of oxycodone are mediated mostly by agonistic effects on the μ-opioid receptor.
Malavika Deodhar +2 more
doaj +1 more source
Scientific Reports, 2023 Opioid-alcohol polysubstance use is prevalent and worsens treatment outcomes. Here we assessed whether co-consumption of oxycodone and alcohol influence the intake of one another, demand for oxycodone, and the neurocircuitry underlying cue-primed ...
Courtney S. Wilkinson +7 more
doaj +1 more source
The effect of icotinib or apatinib on the pharmacokinetic profile of oxycodone in rats and the underlying mechanism [PDF]
PeerJ, 2023 This study aimed to investigate the interactions between icotinib/apatinib and oxycodone in rats and to unveil the underlying mechanism. An ultra-performance liquid chromatography–tandem mass spectrometry (UPLC-MS/MS) method was developed and validated ...
Qi Zhou +7 more
doaj +2 more sources
An observational cohort study comparing ibuprofen and oxycodone in children with fractures.
PLoS ONE, 2021 ObjectiveTo compare the effectiveness and safety of prescribing ibuprofen and oxycodone for at-home management of children's fracture pain.MethodsA prospective observational cohort was conducted at the Stollery Children's Hospital pediatric emergency ...
Samina Ali +8 more
doaj +1 more source
Effects of aprepitant on the pharmacokinetics of controlled-release oral oxycodone in cancer patients. [PDF]
PLoS ONE, 2014 PURPOSE: Oxycodone is a µ-opioid receptor agonist widely used in the treatment of cancer pain. The predominant metabolic pathway of oxycodone is CYP3A4-mediated N-demethylation to noroxycodone, while a minor proportion undergoes 3-O-demethylation to ...
Yutaka Fujiwara +7 more
doaj +1 more source