Results 21 to 30 of about 22,050 (201)

Metabolism of oxycodone in human hepatocytes from different age groups and prediction of hepatic plasma clearance

Frontiers in Pharmacology, 2012
Oxycodone is commonly used to treat severe pain in adults and children. It is extensively metabolized in the liver in adults, but the maturation of metabolism is not well understood. Our aim was to study the metabolism of oxycodone in cryopreserved human
Timo eKorjamo, Ari eTolonen, Veli-Pekka eRanta, Miia eTurpeinen, Hannu eKokki, Hannu eKokki   +5 more
doaj   +1 more source

Oxycodone does not affect placental circulatory physiology during the early first stage of labor—A randomized trial

Acta Obstetricia et Gynecologica Scandinavica, 2023
Introduction Opioids are used for pain relief during the first stage of labor. Oxycodone can cause maternal hypotension that may modify utero‐ and fetoplacental circulatory physiology.
Leena Alanne, Hannu Kokki, Anu Mykkänen, Maija‐Riitta Ordén, Valtteri Rinne, Juha Räsänen, Merja Kokki   +6 more
doaj   +1 more source

Molecularly Imprinted Electrochemical Sensor Based on Poly (O-Phenylenediamine) for Sensitive Detection of Oxycodone in Water

Electrochem, 2023
This work was aimed at the development of a sensitive electrochemical detection method for oxycodone in water. Molecularly imprinted electrodes were formed by electro-polymerization process using o-phenylenediamine as a monomer.
Pranaya Charkravarthula, Amos Mugweru
doaj   +1 more source

Attenuation of opioid tolerance by ETB receptor agonist, IRL-1620, is independent of an accompanied decrease in nerve growth factor in mice

Heliyon, 2017
Aim: ETA receptor antagonists reverse opioid tolerance but the involvement of ETB receptors is unknown. In morphine or oxycodone tolerant mice we investigated (1) the effect of ETB receptor agonist, IRL-1620, on analgesic tolerance; (2) changes in ...
Shruti Gulati, Seema Briyal, Shantel Jones, Shaifali Bhalla, Anil Gulati   +4 more
doaj   +1 more source

Sex and genetic background influence intravenous oxycodone self-administration in the hybrid rat diversity panel

Frontiers in Psychiatry
Opioid Use Disorder (OUD) is an ongoing worldwide public health concern. Genetic factors contribute to multiple OUD-related phenotypes, such as opioid-induced analgesia, initiation of opioid use, and opioid dependence.
Eamonn P. Duffy, Eamonn P. Duffy, Jonathan O. Ward, Luanne H. Hale, Kyle T. Brown, Andrew J. Kwilasz, Erika A. Mehrhoff, Erika A. Mehrhoff, Laura M. Saba, Marissa A. Ehringer, Marissa A. Ehringer, Ryan K. Bachtell, Ryan K. Bachtell   +12 more
doaj   +1 more source

Estrous cycle dependent expression of oxycodone conditioned reward in rats

Scientific Reports, 2023
Oxycodone is one of the most widely prescribed and misused opioid painkillers in the United States. Evidence suggests that biological sex and hormonal status can impact drug reward in humans and rodents, but the extent to which these factors can ...
Jessica A. Babb, Nicholas J. Constantino, Gary B. Kaplan, Elena H. Chartoff   +3 more
doaj   +1 more source

A new therapeutic option for postoperative pain management with oxycodone HCI injection [PDF]

Korean Journal of Anesthesiology, 2016
Fentanyl is the most commonly used opioid analgesic in intravenous patient-controlled analgesia (IV PCA) in Korea. IV oxycodone was approved for postoperative IV PCA by the Ministry of Food and Drug Safety of Korea in 2013.
Byung Moon Choi
doaj   +1 more source

Codeine toxicity via breast Milk: Can this occur and implications for opiate therapy in children

British Journal of Clinical Pharmacology, EarlyView.
Codeine is commonly used in combination analgesic products. The use of codeine during breastfeeding can rarely be associated with serious adverse effects related to genetic polymorphisms affecting codeine's metabolism and disposition. Clinicians treating infants of breastfeeding mothers should be aware of this rare but potentially serious complication.
Michael Rieder
wiley   +1 more source

Development of a nalmefene formulation suitable for a community‐use auto‐injector

British Journal of Clinical Pharmacology, EarlyView.
Aim Time to onset of reversal is critical when treating opioid‐induced respiratory depression and hypoxia. This study aimed to develop a formulation of the opioid antagonist nalmefene with an increased absorption rate and reduced time to onset of reversal following intramuscular administration. Methods Several absorption enhancers were screened in rats,
Alessandra Cipriano, Manjunath S. Shet, Hugh Huang, Ronnie Ortiz, Garth T. Whiteside, Glen Apseloff, Stephen C. Harris   +6 more
wiley   +1 more source

Nonmedical Use of Xtampza® ER and Other Oxycodone Medications in Adults Evaluated for Substance Abuse Treatment: Real-World Data from the Addiction Severity Index-Multimedia Version (ASI-MV®)

Journal of Pain Research, 2021
Jody L Green, Rebekkah S Robbins, Taryn Dailey-Govoni, Stephen F Butler Inflexxion, A Division of Integrated Behavioral Health, Irvine, CA, USACorrespondence: Jody L GreenInflexxion, A Division of Integrated Behavioral Health, 2 Park Plaza, Suite 1200 ...
Green JL, Robbins RS, Dailey-Govoni T, Butler SF   +3 more
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