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Beneficial effects of oxypurinol pretreatment in stunned, reperfused canine myocardium
Cardiovascular Research, 1989The mechanism of reperfusion induced injury in acutely ischaemic myocardium is controversial but may be connected with oxygen free radical generation. However, chronic allopurinol treatment has beneficial effects in ischaemic myocardium which are not due to its inhibition of xanthine oxidase induced oxygen free radical production.
H H, Holzgrefe, J K, Gibson
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Plasma oxypurinol as a measure of adherence in clinical trials
Annals of the Rheumatic Diseases, 2018Adherence to urate-lowering therapy (ULT) in people with gout is often poor. A recent systematic review revealed 10%–46% of people with gout adhere to treatment.1 Among chronic diseases, gout has particularly low adherence rates.2 Adherence in clinical trials of ULT is a particularly important issue, as the primary efficacy endpoint for most studies ...
Lisa K, Stamp +6 more
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The xanthine oxidase inhibitor oxypurinol reduces cancer cachexia-induced cardiomyopathy
International Journal of Cardiology, 2013Cachexia is a common complication of cancer and may be responsible for 22% of all cancer-related deaths. The exact cause of death in cancer cachexia patients is unknown. Recently, atrophy of the heart has been described in cancer cachexia animal models, which resulted in impaired cardiac function and is likely to contribute to mortality.
Springer, Jochen +5 more
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The Allopurinol Hypersensitivity Syndrome: Its Relation to Plasma Oxypurinol Levels
1989Allopurinol (4-hydroxypyrazolo (3, 4-d)pyrimidine) is a potent inhibitor of uric acid synthesis commonly prescribed for the treatment of gout and other hyperuricemic states (1, 2). Most of the allopurinol is rapidly oxidized to oxypurinol, its major metabolic product (3), which in turn is a potent inhibitor of the enzyme xanthine oxydase.
E, Casas +5 more
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Allopurinol hypersensitivity syndrome: hypersensitivity to oxypurinol but not allopurinol.
Clinical and experimental dermatology, 1998Allopurinol is a xanthine oxidase inhibitor widely used to control plasma uric acid levels. Episodes of hypersensitivity to the drug are not rare. A severe form of this with a generalized exanthem, fever and liver involvement has been termed the allopurinol hypersensitivity syndrome (AHS).
H, Hamanaka +4 more
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Oxypurinol attenuates ischemia-induced hippocampal damage in the gerbil
Brain Research Bulletin, 1989Oxypurinol, an inhibitor of the enzyme xanthine oxidase, reduced ischemic hippocampal damage and the associated hypermotility in Mongolian gerbils. Cerebral ischemia was induced in unanesthetized gerbils by a bilateral 5-min occlusion of the carotid arteries.
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The population pharmacokinetics of allopurinol and oxypurinol in patients with gout
European Journal of Clinical Pharmacology, 2013The aims of this study were to develop a population pharmacokinetic model for allopurinol and oxypurinol and to explore the influence of patient characteristics on allopurinol and oxypurinol pharmacokinetics.Data from 92 patients with gout and 12 healthy volunteers were available for analysis.
Daniel F B, Wright +5 more
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Renal Clearances of Purine Bases and Oxypurinol During Glucose Infusion
1995Glucose infusion causes increased excretion of uric acid1, 2, suggesting a functional relationship between the renal handling of uric acid and glucose. Furthermore, some functional association between the renal transport of uric acid, oxypurines and oxypurinol have been suggested3, 4.
Y, Moriwaki +5 more
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Oxypurinol Reduces Ischemic Brain Injury in the Gerbil and Rat
1991The pathophysiology of brain ischemia is characterized by a complex sequence of events, which include biochemical, hemodynamic and electrophysiological processes. Decreases in cerebral blood flow (CBF) below a critical threshold result in energy failure, tissue acidosis, disturbed ion homeostasis, with cellular Na+ and Ca++ influx and K+ efflux ...
J W, Phillis, Y, Lin
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Oxypurinol – A novel marker for wastewater contamination of the aquatic environment
Water Research, 2015The anti-gout agent allopurinol is one of the most prescribed pharmaceuticals in Germany and is widely metabolized into oxypurinol (80%) as well as the corresponding riboside conjugates (10%) within the human body. To investigate the occurrence of allopurinol and oxypurinol in the urban water cycle an analytical method was developed based on solid ...
Jan Funke +3 more
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