Results 101 to 110 of about 645,423 (346)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Regulation of Synaptic Pumilio Function by an Aggregation-Prone Domain [PDF]

, 2010
We identified Pumilio (Pum), a Drosophila translational repressor, in a computational search for metazoan proteins whose activities might be regulated by assembly into ordered aggregates.
Menon, Kaushiki P., Salazar, Anna M., Silverman, Edward J., Zinn, Kai   +3 more
core   +2 more sources

SAPPORO: A way to turn your graphics cards into a GRAPE-6 [PDF]

, 2009
We present Sapporo, a library for performing high-precision gravitational N-body simulations on NVIDIA Graphical Processing Units (GPUs). Our library mimics the GRAPE-6 library, and N-body codes currently running on GRAPE-6 can switch to Sapporo by a ...
Aarseth, Anderson, Belleman, Dorband, Evghenii Gaburov, Fernando, Fernando, Ford, Gualandris, Harfst, Harfst, Heggie, Makino, Makino, Nitadori, Plummer, Portegies Zwart, Portegies Zwart, Portegies Zwart, Simon Portegies Zwart, Stefan Harfst, Sussman, van Meel   +22 more
core   +6 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

MicroRNA-29 family expression and its relation to antiviral immune response and viro-immunological markers in HIV-1-infected patients [PDF]

, 2015
BACKGROUND: Several in vitro studies suggested the microRNA-29 (miRNA-29) family is involved in regulating HIV-1 and modulating the expression of interleukin (IL)-32, an anti-HIV-1 cytokine.
ANTONELLI, Guido, Cacciotti G, D'ETTORRE, Gabriella, FALASCA, FRANCESCA, MEZZAROMA, Ivano, MONTELEONE, Katia, SCAGNOLARI, CAROLINA, SELVAGGI, CARLA, TURRIZIANI, Ombretta, VULLO, Vincenzo   +9 more
core   +2 more sources

Transgenic mouse model for the formation of Hirano bodies

BMC Neuroscience, 2011
Background Hirano bodies are actin-rich cytoplasmic inclusions found predominantly in the brain in association with a variety of conditions including aging and Alzheimer's disease.
Stramiello Michael, Furukawa Ruth, Ha Sangdeuk, Wagner John J, Fechheimer Marcus   +4 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

P-body-like condensates in the germline

Seminars in Cell & Developmental Biology
P-bodies are cytoplasmic condensates that accumulate low-translation mRNAs for temporary storage before translation or degradation. P-bodies have been best characterized in yeast and mammalian tissue culture cells. We describe here related condensates in the germline of animal models.
Cassani, Madeline, Seydoux, Geraldine
openaire   +2 more sources

Geometric properties of the family of p-parallel bodies

Analysis and Geometry in Metric Spaces
We study geometric properties of the family of p-parallel bodies of a convex body K with respect to a gauge body E. In particular, we investigate various regularity properties of their boundaries by means of their 0-extreme vectors, aiming for extensions
Hernández Cifre María A., Martínez Fernández Antonio R., Saorín Gómez Eugenia   +2 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source