Results 111 to 120 of about 645,423 (346)

Identification and stage-specific association with the translational apparatus of TbZFP3, a CCCH protein that promotes trypanosome life-cycle development [PDF]

, 2006
The post-transcriptional control of gene expression is becoming increasingly important in the understanding of regulated events in eukaryotic cells. The parasitic kinetoplastids have a unique reliance on such processes, because their genome is organized ...
Athina Paterou, Barreau, Berriman, Biebinger, Blackshear, Brecht, Breeden, Caro, Chekulaeva, Chen, Clayton, Gao, Gietz, Guedes, Gunzl, Hammarton, Hammarton, Hendriks, Hendriks, Hollenberg, Hudson, Ivens, Katelyn Fenn, Keene, Keith Matthews, Lai, Matthews, Matthews, Moore, Morking, Ogura, Paul Craddy, Pegine Walrad, Priest, Reese, Rudenko, Schmitz, Sutton, Tabara, Tacahashi, Tenenhaus, Tielens, Tu, Tu, van Deursen, van Weelden, Wentz-Hunter, Wickens, Ziegelbauer   +48 more
core   +1 more source

FTO‐mediated m6A demethylation regulates IGFBP3 expression and AKT activation through IMP3‐dependent P‐body re‐localisation in lung cancer

Clinical and Translational Medicine
Lung cancer remains one of the leading causes of cancer‐related deaths worldwide, and a growing body of evidence suggests that RNA modifications, including methylation, play a critical role in its progression.
Haiyang Wang, Hui Peng, Zhenzhen Zhang, Yilimunuer Abulimiti, Jiayi Hu, Yongxin Zhou, Ping Ji, Dong Li   +7 more
doaj   +1 more source

The role of DEAD- and DExH-box RNA helicases in neurodevelopmental disorders

Frontiers in Molecular Neuroscience
Neurodevelopmental disorders (NDDs) represent a large group of disorders with an onset in the neonatal or early childhood period; NDDs include intellectual disability (ID), autism spectrum disorders (ASD), attention deficit hyperactivity disorders (ADHD),
Johannes Lederbauer, Johannes Lederbauer, Sarada Das, Amelie Piton, Davor Lessel, Davor Lessel, Hans-Jürgen Kreienkamp   +6 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Drug-induced stress granule formation protects sensory hair cells in mouse cochlear explants during ototoxicity [PDF]

, 2019
Stress granules regulate RNA translation during cellular stress, a mechanism that is generally presumed to be protective, since stress granule dysregulation caused by mutation or ageing is associated with neurodegenerative disease.
Dawson, Sally J., Gale, Jonathan E., Gonçalves, Ana Cláudia, Haq, Naila, Pelletier, Jerry, Porco, John A., Towers, Emily R.   +6 more
core   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Rational engineering of microRNA-regulated viruses for cancer gene therapy [PDF]

, 2013
MicroRNAs (miRNAs) are small noncoding RNA molecules that have important regulatory roles in a wide range of biological processes. miRNAs are often expressed in a tissue- and/or differentiation state-specific patterns, and it is estimated that miRNAs can
Ylösmäki, Erkko
core  

Unconventional miR-122 binding stabilizes the HCV genome by forming a trimolecular RNA structure. [PDF]

, 2013
MicroRNAs (miRNAs) typically downregulate protein expression from target mRNAs through limited base-pairing interactions between the 5' 'seed' region of the miRNA and the mRNA 3' untranslated region (3'UTR). In contrast to this established mode of action,
Doudna, Jennifer A, Mortimer, Stefanie A
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Cell-cycle-dependent mRNA localization in P-bodies

Molecular Cell
SummaryUnderstanding the dynamics of RNA targeting to membraneless organelles is essential to disentangle their functions. Here, we investigate how P-bodies (PBs) evolve during cell cycle progression. PB purification across the cell cycle uncovers widespread changes in their RNA content, which are partly uncoupled from cell cycle-dependent changes in ...
Safieddine, Adham, Benassy, Marie-Noëlle, Bonte, Thomas, Slimani, Floric, Pourcelot, Oriane, Kress, Michel, Ernoult-Lange, Michèle, Courel, Maïté, Coleno, Emeline, Imbert, Arthur, Laine, Antoine, Godebert, Annie Munier, Vinit, Angelique, Blugeon, Corinne, Chevreux, Guillaume, Gautheret, Daniel, Walter, Thomas, Bertrand, Edouard, Bénard, Marianne, Weil, Dominique   +19 more
openaire   +5 more sources