Results 141 to 150 of about 19,519,160 (297)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

(Re)moving Bodies in Museums

, 2013
The paper revolves around cases of movements and re-movements of animal and human bodies in museums, mirroring ideological movements and changes, movements of the (physical but non-living) bodies in time and space as well as representations of time and ...
Samuelsson, Anna,
core  

Effect of Two Different Polysaccharides on the Stability of Emulsion Formed by Rapeseed Oil Bodies

Shipin gongye ke-ji
In order to improve the stability of emulsions of rapeseed oil bodies under different environmental conditions. The soluble soybean polysaccharide (SSPS) with negative electric charge and konjac glucomannan (KGM) without electric charge were used to form
Shenghua HE, Sanjiu ZHOU, Yonghui WANG, Guanghui LI, Xueli GAO, Weiyun GUO   +5 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

SMG7 and eIF4A constitute a homeostatic module controlling P-body condensation and function of meiotic bodies

Nature Communications
Processing bodies (P-bodies) are ribonucleoprotein condensates that regulate RNA processing and storage. Although constitutively present in most cells, their size and composition change dynamically in response to developmental and environmental cues ...
Albert Cairo, Neha Shukla, Sofia Kanavorova, Jan Skalak, Pavlina Mikulkova, Anna Vargova, David Potesil, Zbynek Zdrahal, Jan Hejatko, Karel Riha   +9 more
doaj   +1 more source

RNA helicase DDX6 and scaffold protein GW182 in P-bodies promote biogenesis of stress granules. [PDF]

Nucleic Acids Res, 2023
Majerciak V, Zhou T, Kruhlak MJ, Zheng ZM.   +3 more
europepmc   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Neolithic bodies

, 2018
As a result of recent methodological and theoretical developments in approaches to the human body in archaeological contexts, the theme has recently become a particularly dynamic research area.
Sibbesson, E.
core  

ADAD2 interacts with RNF17 in P-bodies to repress the Ping-pong cycle in pachytene piRNA biogenesis. [PDF]

J Cell Biol, 2023
Xiong M, Yin L, Gui Y, Lv C, Ma X, Guo S, Wu Y, Feng S, Fan X, Zhou S, Wang L, Wen Y, Wang X, Xie Q, Namekawa SH, Yuan S.   +15 more
europepmc   +1 more source