Results 31 to 40 of about 21,376,824 (184)
mBio, 2019 Studies of the intestinal microbiome and AD have demonstrated associations with microbiome composition at the genus level among matched cohorts. We move this body of literature forward by more deeply investigating microbiome composition via metagenomics ...
J. Haran +6 more
semanticscholar +1 more source
Pharmaceutics, 2023 Triple-negative breast cancer (TNBC) is a highly aggressive disease with rapid progression and poor prognosis due to multidrug resistance (MDR).
Wenwen Xu +5 more
doaj +1 more source
P-Glycoprotein in Clinical Cardiology [PDF]
Circulation, 1999 Ever since Juliano and Ling first described P-glycoprotein (P-gp) in 1975,1 it has become an important focus of research. P-gp is a member of the ATP-binding cassette (ABC) superfamily of proteins that is highly conserved in distantly related species (from simple eukaryotes to vertebrates).2 These similarities across species suggest that P-gp plays an ...
I, Rodriguez +2 more
openaire +2 more sources
P-glycoprotein expression in retinoblastoma [PDF]
British Journal of Ophthalmology, 2005 We have read with interest the paper by Krishnakumar et al .1 We have studied 18 children with retinoblastoma using immunohistochemical detection of P-glycoprotein by the mouse monoclonal antibody HYB-241 in frozen section tumour samples. Like Krishnakumar et al , we found limited expression of P-glycoprotein in retinoblastoma cells since only four of ...
I J, Dunkel +5 more
openaire +2 more sources
Molecules, 2016 P-glycoprotein (P-gp) affects the transport of many drugs; including puerarin and vincristine. Our previous study demonstrated that imperatorin increased the intestinal absorption of puerarin and vincristine by inhibiting P-gp-mediated drug efflux ...
Zheng-Gen Liao +7 more
doaj +1 more source
HPLC methods of fexofenadine quantitative analysis in rabbits’ liver
Фармация и фармакология (Пятигорск), 2020 The investigation of pharmacokinetics of marker substrates of carrier protein P-glycoprotein (Pgp, ABCB1-protein) including fexofenadine, is one of the methods of its functional activity evaluation.The aim of the study was to work out the HPLC methods of
P. Yu. Mylnikov +4 more
doaj +1 more source
Intracellular trafficking of P-glycoprotein [PDF]
The International Journal of Biochemistry & Cell Biology, 2012 Overexpression of P-glycoprotein (P-gp) is a major cause of multidrug resistance in cancer. P-gp is mainly localized in the plasma membrane and can efflux structurally and chemically unrelated substrates, including anticancer drugs. P-gp is also localized in intracellular compartments, such as endoplasmic reticulum (ER), Golgi, endosomes and lysosomes,
Dong, Fu, Irwin M, Arias
openaire +2 more sources
Mechanism of allosteric modulation of P-glycoprotein by transport substrates and inhibitors
Science, 2019 Transport control The membrane protein P-glycoprotein protects cells by using energy from adenosine triphosphate (ATP) hydrolysis to expel chemical substances, including drugs. Inhibiting P-glycoprotein may thus ameliorate drug resistance.
Reza Dastvan +4 more
semanticscholar +1 more source
MoleculesP-Glycoprotein (P-gp, also known as MDR1 or ABCB1) is an ATP-binding cassette (ABC) transporter that actively effluxes a wide range of structurally and functionally diverse molecules, playing a crucial role in drug absorption, distribution, and excretion.
Francesco Mastropasqua +3 more
doaj +1 more source