Results 51 to 60 of about 21,376,824 (184)
Indian Journal of Rheumatology, 2020 Background: P-glycoprotein (P-gp) overexpression in peripheral blood mononuclear cells (PBMCs) has been reported in patients with steroid-resistant nephrotic syndrome (SRNS).
Harshit Singh +4 more
doaj +1 more source
Future Journal of Pharmaceutical Sciences, 2021 Background Six different metal complexes of quercetin (Cu, Zn, Co, Vd, Mo, Ni) were synthesized, purified, and characterized by their physical and spectral (UV, IR) data.
Kirankumar Shastrala +7 more
doaj +1 more source
Effects of Polyphenols on P-Glycoprotein (ABCB1) Activity
Pharmaceutics, 2021 P-glycoprotein (Pgp, ABCB1) is a member of one of the largest families of active transporter proteins called ABC transporters. Thanks to its expression in tissues with barrier functions and its broad substrate spectrum, it is an important determinant of ...
Kuljeet Singh +7 more
doaj +1 more source
Annotating Human P‐Glycoprotein Bioassay Data [PDF]
Molecular Informatics, 2012 AbstractHuge amounts of small compound bioactivity data have been entering the public domain as a consequence of open innovation initiatives. It is now the time to carefully analyse existing bioassay data and give it a systematic structure. Our study aims to annotate prominent in vitro assays used for the determination of bioactivities of human P ...
Zdrazil +10 more
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Pharmaceutics, 2020 The rat is one of the most commonly used animal models in pre-clinical studies. Limited information between the sexes and the effect of food consumption on the gastrointestinal (GI) physiology, however, is acknowledged or understood.
Liu Dou +7 more
doaj +1 more source
Refined structures of mouse P‐glycoprotein [PDF]
Protein Science, 2013 Abstract The recently determined C. elegans P‐glycoprotein (Pgp) structure revealed significant deviations compared to the original mouse Pgp structure, which suggested possible misinterpretations in the latter model.
Aller, Stephen G. +2 more
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Curcumin as a Modulator of P-Glycoprotein in Cancer: Challenges and Perspectives
Pharmaceuticals, 2016 Multidrug resistance (MDR) presents a serious challenge to the efficiency of cancer treatment, and may be associated with the overexpression of drug efflux pumps.
V. Lopes-Rodrigues +4 more
semanticscholar +1 more source
The catalytic cycle of P‐glycoprotein [PDF]
FEBS Letters, 1995 P‐glycoprotein is a plasma‐membrane glycoprotein which confers multidrug‐resistance on cells and displays ATP‐driven drug‐pumping in vitro. It contains two nucleotide‐binding domains, and its structure places it in the ‘ABC transporter’ family. We review recent evidence that both nucleotide‐sites bind and hydrolyse Mg‐ATP.
Senior, Alan E. +2 more
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Snapshots of ligand entry, malleable binding and induced helical movement in P-glycoprotein
Acta Crystallographica Section D: Biological Crystallography, 2015 Co-crystal structures of P-glycoprotein with a series of engineered ligands reveal multiple ligand-binding modes, a ligand-binding site on the outer surface of the transporter and a conformational change that may couple to ATP hydrolysis.
P. Szewczyk +9 more
semanticscholar +1 more source
Convallatoxin: A new P-glycoprotein substrate [PDF]
European Journal of Pharmacology, 2014 Digitalis-like compounds (DLCs), such as digoxin and digitoxin that are derived from digitalis species, are currently used to treat heart failure and atrial fibrillation, but have a narrow therapeutic index. Drug-drug interactions at the transporter level are frequent causes of DLCs toxicity.
Gozalpour, Elnaz +7 more
openaire +4 more sources