Results 171 to 180 of about 243,388 (247)

P glycoprotein (ABCB1; MDR1; P-gp) [PDF]

Science-Business eXchange, 2009
openaire   +1 more source

Expression and interaction of RNA binding protein HuR with multidrug transporters (P-GP, MRP1, and ABCG2) in chemoresistant breast and colorectal cancer cells. [PDF]

J Genet Eng Biotechnol
Nath SD, Akash MMH, Tanim MTH, Akhteruzzaman S, Mostafa MG, Sajib AA.   +5 more
europepmc   +1 more source

LLMs as Representation Generators for Gradient‐Free Scientific Optimization: A Case Study in Battery Fast Charging

Advanced Science, EarlyView.
Large language models serve as representation generators for gradient‐free scientific optimization. Two complementary approaches produce executable battery‐charging policies either directly or through LLM‐designed neural representations coupled to Bayesian optimization.
Ge Lei, Ferran Brosa Planella, Sterling G. Baird, Samuel J. Cooper   +3 more
wiley   +1 more source

Isoorientin Modulates Gut Microbes and Their Metabolites to Alleviate Caco-2 Cell Monolayer Inflammation by Reducing Intestinal Permeability via P-Gp/eCBs. [PDF]

J Inflamm Res
Wang Z, Jiang Y, Duan B, Zhang H, Li A, Yang J, Lv M, Yang J.   +7 more
europepmc   +1 more source

Q‐LEAP: Millisecond Hyperdimensional Optimization for Full‐Spectrum Optical Metamaterials

Advanced Science, EarlyView.
Q‐LEAP integrates physics‐informed residual machine learning with factorization‐machine‐encoded quantum annealing to design full‐spectrum optical metamaterials. It explores a 2108 design space and, in a single 2.56 ms annealing step, reaches 85.83% of the theoretical FoM limit, enabling selective 5‐8 µm emission with 3–5 and 8–14 µm suppression and ∼40×
Zikang Guo, Yunwen Wu, Yuhui Guo, Shenghong Ju   +3 more
wiley   +1 more source

P-gp quantification for cell resistance studies in leukemia cells using the innovative LightSpot-FL-1 fluorescent conjugate. [PDF]

Sci Rep
Dubois M, Goisnard A, Bourgne C, Gay E, Depresle M, Roux M, Voisin A, Berger M, Penault-Llorca F, Mounetou E, Daumar P, Bamdad M.   +11 more
europepmc   +1 more source

PBRM1 Deficiency in Microglia Leads to Excessive Neurogenesis and Autism‐Like Behaviors via the CCL5‐CCR1/5‐β‐catenin Signaling Axis

Advanced Science, EarlyView.
Microglial PBRM1 deficiency drives excessive hippocampal neurogenesis by enhancing CCL5–CCR1/5 signaling, leading to autism‐like behaviors. A pro‐inflammatory IL1α+/TNFα+ microglial subset is identified as a key cellular contributor to this process. PBRM1 represses Ccl5 expression at the transcriptional level.
Yang‐Yang Duan, Lin‐Fei Jiao, Pei‐Pei Liu, Chun‐Hui Duan, Xiao Li, Zi‐Han Zhang, Yue‐Qi Zhang, Xin‐Li Ouyang, Hong‐Zhen Du, Sha Liu, Yi Tang, Zhao‐Qian Teng, Chang‐Mei Liu   +12 more
wiley   +1 more source

Impact of P-gp inhibition on systemic exposure of pralsetinib and dosing considerations. [PDF]

Clin Transl Sci
Suchomel J, Agarwal P, Anders D, Hughes K, Tang Y, Sane R, Scalori A, Sharma S, Cheeti S.   +8 more
europepmc   +1 more source

Modifying Electrochemical Doping in Light‐Emitting Electrochemical Cells With Gold Nanoparticles

Advanced Science, EarlyView.
This study shows that gold nanoparticles placed at an electrode can control how electrochemical doping occurs in organic electronic devices. Particularly, in light‐emitting electrochemical cells, by shifting the light‐emitting region, device efficiency is improved without altering the emissive material. This approach provides a simple and effective way
Ajay K. Poonia, Anton Kirch, Joan Ràfols‐Ribé, Lucrezia Catanzaro, Anish Rao, Karol Kołątaj, Vittorio Scardaci, Giuseppe Compagnini, Guillermo P. Acuna, Ludvig Edman, Nicolò Maccaferri   +10 more
wiley   +1 more source