Results 181 to 190 of about 243,388 (247)

LightSpot Fluorescent Conjugates as Highly Efficient Tools for Lysosomal P-gp Quantification in Olaparib-Treated Triple-Negative Breast Cancer Cells. [PDF]

Int J Mol Sci
Goisnard A, Daumar P, Dubois M, Gay E, Roux M, Depresle M, Penault-Llorca F, Mounetou E, Bamdad M.   +8 more
europepmc   +1 more source

3D Bioprinted Blood–Brain–Tumor Barrier Spheroid‐Based In Situ Evaluation of Anticancer Compounds Against Glioblastoma: ROS‐Producing Ruthenium as a Potential Therapeutic Candidate

Advanced Science, EarlyView.
The blood–brain–tumor barrier (BBTB) penetration by anticancer drugs and their effects on glioblastoma (GBM) is assessed using 3D bioprinted‐spheroids. Anticancer drug‐induced U‐87 MG cell death is quantified through in situ imaging of spheroids using a cancer cell death probe. The Ru compound, a partial P‐gp substrate, induces greater tumor‐cell death
Hyunjung Lee, Chan Ho Jeon, Doyun Kim, Minjae Lee, Minji Kwon, Joon Myong Song   +5 more
wiley   +1 more source

In Vitro and Clinical Evaluations of UGT1A1-, P-gp-, OATP1B1-, and BCRP-Mediated Drug-Drug Interactions of Belumosudil, a Potent ROCK2 Inhibitor. [PDF]

J Clin Pharmacol
Schueller O, Lohmer L, Beck F, Patel J, Sahi J.   +4 more
europepmc   +1 more source

Low Threshold Vertical Cavity Surface Emitting Lasers Based on CsPbI3 Thin Films

Advanced Science, EarlyView.
The first vertical‐cavity surface‐emitting laser (VCSEL) based on CsPbI3 thin films is fabricated by planar hot pressing. By optimizing the cavity design through optical gain assessment and rigorous coupled‐wave analysis, the VCSEL achieved an exceptionally low lasing threshold of 2.8 µJ cm−2.
Naho Kurahashi, Maximilian Schiffer, Cedric Kreusel, Christian Tückmantel, Ahmed Kadid, Habib Ur Rehman, Florian Gaschler, René Anfang, Christopher Knoth, Maximilian Buchmüller, Patrick Görrn, Thomas Riedl   +11 more
wiley   +1 more source

P glycoprotein (P-gp) and drug resistance – time for reappraisal? [PDF]

British Journal of Cancer, 1993
openaire   +2 more sources

Co-expression of HIF1A with multi-drug transporters (P-GP, MRP1, and BCRP) in chemoresistant breast, colorectal, and ovarian cancer cells. [PDF]

J Genet Eng Biotechnol
Nath SD, Hossain Tanim MT, Akash MMH, Golam Mostafa M, Sajib AA.   +4 more
europepmc   +1 more source

Massively Multiplexed Photonic Chip With Cross‐Channel Fusion For Harmonized Biosensing

Advanced Science, EarlyView.
We introduce a transformative sensing platform integrating photonic multiplexing with over 10 000 sensors and a deep‐learning framework that combines domain adaptation and cross‐channel fusion for harmonized operation across heterogeneous chips. The platform achieves 99.3% identification accuracy and relative prediction errors of 10−4$^{-4}$ for ...
Ivan Saetchnikov, Elina Tcherniavskaia, Andreas Ostendorf, Anton Saetchnikov   +3 more
wiley   +1 more source

Bisecting GlcNAc modification reverses the chemoresistance via attenuating the function of P-gp. [PDF]

Theranostics
Tan Z, Ning L, Cao L, Zhou Y, Li J, Yang Y, Lin S, Ren X, Xue X, Kang H, Li X, Guan F.   +11 more
europepmc   +1 more source

Spatiotemporal Regulation of Hierarchical Assembly of Hydroxyapatite for Enamel Remineralization

Advanced Science, EarlyView.
Biomimetic repair exhibits unique advantages for enamel regeneration compared with conventional clinical treatments. An enzymatic mineralization system (EMS) is developed, where the resulting HAP nanorods hierarchically assemble into a highly ordered structure on the enamel surface through the spatiotemporal modulation of interfacial energies of ...
Zhenhang Tang, Zhisen Zhang, Yuanyu Zhou, Wenzhi Wu, Congrui Zhao, Chang Liu, Tong Shi, Wenjing Jin, Zhaoming Liu, Weifeng Fang, Qingyun Lin, Yi He, Zhijian Xie, Ruikang Tang, Changyu Shao, Zhuo Chen   +15 more
wiley   +1 more source

Folic Acid-Modified Ginger-Derived Exosome-Like Nanoparticles Co-Delivering Sunitinib Suppress Renal Cell Carcinoma via PI3K-Akt Pathway Inhibition, P-gp Downregulation, and Macrophage Reprogramming. [PDF]

Adv Sci (Weinh)
Xu H, Hu D, Liu S, Yang L, Li J, Bai Y, Zhao G, Tang W, Jiang L.   +8 more
europepmc   +1 more source