Results 221 to 230 of about 20,489,060 (330)

Clinical Evaluation of Drug-Drug Interactions Between Bictegravir and Strong Inhibitors/Inducers of the CYP3A4, UGT1A1, or P-gp Pathways. [PDF]

J Clin Pharmacol
Arora P, Liu H, Ling J, Hindman JT, Marathe DD.   +4 more
europepmc   +1 more source

All‐in‐One Underwater Quality Evaluation Metamaterial With Mechanical Robustness, Sound Attenuation, and Diffuse Reflection

Advanced Science, EarlyView.
In this work, a bioinspired all‐in‐one underwater quality evaluation metamaterial, combining sound attenuation, diffuse reflection, and mechanical robustness, is proposed based on jumping spider locomotion and human skeletal biomechanics. Meanwhile, a CNN‑driven quality evaluation framework is established for theoretically dimension‐reduced ...
Hongze Li, Zhenyu Li, Jinshui Yang, Jianhao Wu, Yidan Chen, Linzhi Wu, Hong Hu, Penglin Gao, Yegao Qu   +8 more
wiley   +1 more source

A phase I drug-drug interaction study to assess the effect of futibatinib on P-gp and BCRP substrates and of P-gp inhibition on the pharmacokinetics of futibatinib. [PDF]

Clin Transl Sci
Long A, Yamamiya I, Valentine M, Machnes Z, Hangai N, Anderson B, Wacheck V, Gao L.   +7 more
europepmc   +1 more source

Sustainable Materials Design With Multi‐Modal Artificial Intelligence

Advanced Science, EarlyView.
Critical mineral scarcity, high embodied carbon, and persistent pollution from materials processing intensify the need for sustainable materials design. This review frames the problem as multi‐objective optimization under heterogeneous, high‐dimensional evidence and highlights multi‐modal AI as an enabling pathway.
Tianyi Xu, Tianshuo Wei, Yan Ge, Bo Peng, Yue Li, Maolin Wang, Peng Wen, Chao Yang, Ye Wei   +8 more
wiley   +1 more source

Isoorientin Modulates Gut Microbes and Their Metabolites to Alleviate Caco-2 Cell Monolayer Inflammation by Reducing Intestinal Permeability via P-Gp/eCBs. [PDF]

J Inflamm Res
Wang Z, Jiang Y, Duan B, Zhang H, Li A, Yang J, Lv M, Yang J.   +7 more
europepmc   +1 more source

Synergistic Pyro‐Phototronics and Structural Anisotropy in CsAg2I3/GaN Heterostructures for High‐Performance Polarization‐Sensitive UV Photodetectors

Advanced Science, EarlyView.
The development of polarization‐sensitive ultraviolet photodetectors is limited by poor heterojunction quality and low polarization sensitivity. This study integrates synthesized CsAg2I3 single crystals with intrinsic non‐centrosymmetry into van der Waals heterojunction devices, demonstrating pronounced pyro‐phototronic effect.
Yalin Zhai, Siqi Wang, Peng Guo, Songling Feng, Peng Wan, Jilong Tang, Caixia Kan, Hui Li, Daning Shi, Mingming Jiang   +9 more
wiley   +1 more source

P-gp quantification for cell resistance studies in leukemia cells using the innovative LightSpot-FL-1 fluorescent conjugate. [PDF]

Sci Rep
Dubois M, Goisnard A, Bourgne C, Gay E, Depresle M, Roux M, Voisin A, Berger M, Penault-Llorca F, Mounetou E, Daumar P, Bamdad M.   +11 more
europepmc   +1 more source

A FAP‐Targeted SMDC Platform Enables Synergistic Radionuclide–Chemotherapy with PET‐Guided Evaluation

Advanced Science, EarlyView.
A fibroblast activation protein (FAP)‐targeted small molecule–drug conjugate (SMDC) platform is developed to integrate PET imaging with synergistic radionuclide–chemotherapy. Linker chemistry governs stability, exposure, and tolerability, with the VC linker providing superior in vivo performance.
Ruitao Yang, Hongxin Li, Zexin Xu, Baocheng Chen, Ningjie Li, Yuhua Zhong, Kongzhen Hu   +6 more
wiley   +1 more source

LightSpot Fluorescent Conjugates as Highly Efficient Tools for Lysosomal P-gp Quantification in Olaparib-Treated Triple-Negative Breast Cancer Cells. [PDF]

Int J Mol Sci
Goisnard A, Daumar P, Dubois M, Gay E, Roux M, Depresle M, Penault-Llorca F, Mounetou E, Bamdad M.   +8 more
europepmc   +1 more source

Shadow‐Calibrated Stereo Vision for Colorimetric Sweat Analysis

Advanced Science, EarlyView.
By establishing a mathematical model that reconstructs 3D structures through geometric features of object shadows under controlled illumination, and combining it with Convolutional Neural Network‐based 2D image analysis for volumetric calibration, this work enables highly accurate 3D morphological reconstruction.
Ting Xiao, Yuwen Yan, Miaorong Lin, Jiahui Chen, Jianxin Meng, Xiang Cui, Peng Zhang, Fengyu Li   +7 more
wiley   +1 more source