Results 211 to 220 of about 243,388 (247)

HFD-induced Alterations in Renal Tubular Oatp4c1-P-gp Transport Systems in Mice: Impact on Digoxin Renal Excretion and Gadolinium-Enhanced Radiological Manifestations. [PDF]

Curr Drug Metab
Men J, Li J, Zhang T, Chen Y, Xu B, Hou H, Sun L, Yue H, Duan Z, Gui T, Gai Z.   +10 more
europepmc   +1 more source

Machine learning–driven design of catalytic processes for sulfur dioxide oxidation: Lessons from the trenches

AIChE Journal, EarlyView.
Abstract Despite the growing use of ML in chemical engineering, the catalytic conversion of sulfur dioxide (SO2) to sulfur trioxide (SO3) remains underexplored from a data‐driven modeling perspective. This study evaluates an integrated workflow for literature‐derived SO2 oxidation data, combining data curation, preprocessing assessment, machine ...
Farough Agin, Jules Thibault, Clémence Fauteux‐Lefebvre   +2 more
wiley   +1 more source

The Role of Elacridar, a P-gp Inhibitor, in the Re-Sensitization of PAC-Resistant Ovarian Cancer Cell Lines to Cytotoxic Drugs in 2D and 3D Cell Culture Models. [PDF]

Int J Mol Sci
Stasiak P, Sopel J, Lipowicz JM, Rawłuszko-Wieczorek AA, Korbecki J, Januchowski R.   +5 more
europepmc   +1 more source

Data‐Guided Photocatalysis: Supervised Machine Learning in Water Splitting and CO2 Conversion

Advanced Intelligent Discovery, EarlyView.
This review highlights recent advances in supervised machine learning (ML) for photocatalysis, emphasizing methods to optimize photocatalyst properties and design materials for solar‐driven water splitting and CO2 reduction. Key applications, challenges, and future directions are discussed, offering a practical framework for integrating ML into the ...
Paul Rossener Regonia, Christian Mark Pelicano   +1 more
wiley   +1 more source

Multidrug resistance transporters P-gp and BCRP limit the efficacy of ATR inhibitor ceralasertib in cancer cells. [PDF]

Front Pharmacol
Chen XY, Wu ZX, Wang JQ, Teng QX, Tang H, Liu Q, Chen ZS, Chen W.   +7 more
europepmc   +1 more source

Understanding CYP3A4 and P-gp mediated drug-drug interactions through PBPK modeling - Case example of pralsetinib. [PDF]

CPT Pharmacometrics Syst Pharmacol
Bowman C, Dolton M, Ma F, Cheeti S, Kuruvilla D, Sane R, Kassir N, Chen Y.   +7 more
europepmc   +1 more source

Retraction: Iso-pencillixanthone A from a marine-derived fungus reverses multidrug resistance in cervical cancer cells through down-regulating P-gp and re-activating apoptosis. [PDF]

RSC Adv
Chen L, Li X, Cheng M, Wang S, Zheng Q, Liu Q.   +5 more
europepmc   +1 more source

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Modulation of P-gp expression by lapatinib

Investigational New Drugs, 2010
Chemotherapy drug resistance is a major obstacle in the treatment of cancer. It can result from an increase in levels of cellular drug efflux pumps, such as P-glycoprotein (P-gp). Lapatinib, a growth factor receptor tyrosine kinase inhibitor, is currently in clinical trials for treatment of breast cancer.
Gráinne, Dunne, Laura, Breen, Denis M, Collins, Sandra, Roche, Martin, Clynes, Robert, O'Connor   +5 more
openaire   +2 more sources

Dietary regulation of P-gp function and expression

Expert Opinion on Drug Metabolism & Toxicology, 2009
Food-drug interactions have been associated with clinically important pharmacokinetic and pharmacodynamic changes of a drug. The aim of this paper is to review the regulation of P-glycoprotein (P-gp) by dietary components and to correlate the changes in cellular P-gp function and expression with drug bioavailability.
Wenxia, Zhang, Yi, Han, Siok Lam, Lim, Lee Yong, Lim   +3 more
openaire   +2 more sources

Generalisation of GPS and P-GPS in network calculus

2012 9th IEEE International Workshop on Factory Communication Systems, 2012
GPS is an ideal well known policy designed to share the capacity of a server between the input flows: each flow receives a fractional part, defined by the administrator, of the total server capacity1. It has several practical implementations, like P-GPS. These policies have been defined in the context of a constant-rate server.
William Mangoua Sofack, Marc Boyer
openaire   +2 more sources