Results 51 to 60 of about 113,808 (269)

Molecular marker identification for relapse prediction in 5-FU-based adjuvant chemotherapy in gastric and colorectal cancers. [PDF]

PLoS ONE, 2012
To confirm the clinical significance of NF-κB and JNK protein expression from experimentally identified candidates for predicting prognosis for patients with 5-FU treatment, we evaluated the protein expression of surgically removed specimens.
Kazushige Ishida, Satoshi S Nishizuka, Takehiro Chiba, Miyuki Ikeda, Kohei Kume, Fumitaka Endo, Hirokatsu Katagiri, Teppei Matsuo, Hironobu Noda, Takeshi Iwaya, Noriyuki Yamada, Hisataka Fujiwara, Masanori Takahashi, Tetsuya Itabashi, Noriyuki Uesugi, Chihaya Maesawa, Gen Tamura, Tamotsu Sugai, Koki Otsuka, Keisuke Koeda, Go Wakabayashi   +20 more
doaj   +1 more source

c-Jun N-Terminal Kinase in Inflammation and Rheumatic Diseases. [PDF]

, 2012
The c-Jun N-terminal kinases (JNKs) are members of the mitogen-activated protein kinase (MAPK) family and are activated by environmental stress. JNK is also activated by proinflammatory cytokines, such as TNF and IL-1, and Toll-like receptor ligands ...
Firestein, Gary S, Guma, Monica
core   +1 more source

Regulation of the JNK pathway by TGF-beta activated kinase 1 in rheumatoid arthritis synoviocytes. [PDF]

, 2007
c-Jun N-terminal kinase (JNK) contributes to metalloproteinase (MMP) gene expression and joint destruction in inflammatory arthritis. It is phosphorylated by at least two upstream kinases, the mitogen-activated protein kinase kinases (MEK) MKK4 and MKK7,
Boyle, David L, Firestein, Gary S, Hammaker, Deepa R, Inoue, Tomoyuki   +3 more
core   +2 more sources

Loureirin B Inhibits Hypertrophic Scar Formation via Inhibition of the TGF-β1-ERK/JNK Pathway

Cellular Physiology and Biochemistry, 2015
Background/Aims: Our previous study confirmed that Loureirin B (LB) can inhibit hypertrophic scar formation. However, the mechanism of LB-mediated inhibition of scar formation is still unknown.
Ting He, Xiaozhi Bai, Longlong Yang, Lei Fan, Yan Li, Linlin Su, Jianxin Gao, Shichao Han, Dahai Hu   +8 more
doaj   +1 more source

Inhibition of spinal astrocytic c-Jun N-terminal kinase (JNK) activation correlates with the analgesic effects of ketamine in neuropathic pain

Journal of Neuroinflammation, 2011
Background We have previously reported that inhibition of astrocytic activation contributes to the analgesic effects of intrathecal ketamine on spinal nerve ligation (SNL)-induced neuropathic pain. However, the underlying mechanisms are still unclear.
Wang Wen, Zhai Ming-Zhu, Wei Yan-Yan, Wang Wei, Zhang Hui, Mei Xiao-Peng, Xu Li-Xian, Li Yun-Qing   +7 more
doaj   +1 more source

Pramanicin analog induces apoptosis in human colon cancer cells: critical roles for Bcl-2, Bim, and p38 MAPK signaling [PDF]

, 2013
Pramanicin (PMC) is an antifungal agent that was previously demonstrated to exhibit antiangiogenic and anticancer properties in a few in vitro studies. We initially screened a number of PMC analogs for their cytotoxic effects on HCT116 human colon cancer
Başağa, Hüveyda, Bodur, Çağrı, Harrison, Paul, Isimjan, Tayirjan T., Karslı, Gizem, Kütük, Özgür   +5 more
core   +1 more source

Propofol Suppressed Hypoxia/Reoxygenation‐Induced Apoptosis in HBVSMC by Regulation of the Expression of Bcl‐2, Bax, Caspase3, Kir6.1, and p‐JNK [PDF]

Oxidative Medicine and Cellular Longevity, 2016
Recent studies have found that propofol may protect brain from cerebral ischemic‐reperfusion injury. However, the underlying mechanism remains unclear. The effects of propofol were evaluated in HBVSMC after hypoxia/reoxygenation (H/R). Cell viability and levels of SOD, LDH, and MDA were measured. Apoptosis was detected by flow cytometry.
Zhang, Jianhai, Xia, Yunfei, Xu, Zifeng, Deng, Xiaoming   +3 more
openaire   +2 more sources

Sonic Hedgehog Regulates Proliferation, Migration and Invasion of Synoviocytes in Rheumatoid Arthritis via JNK Signaling

Frontiers in Immunology, 2020
Activated fibroblast-like synoviocytes (FLSs) play a central role in the formation of synovial pannus and joint destruction in rheumatoid arthritis (RA). Targeting FLSs could be a potential therapeutic strategy.
Shangling Zhu, Yuanmei Ye, Yiming Shi, Junlong Dang, Xiaoxue Feng, Yingdi Chen, Fang Liu, Nancy Olsen, Jianlin Huang, Song Guo Zheng   +9 more
doaj   +1 more source

CR3 and Dectin-1 Collaborate in Macrophage Cytokine Response through Association on Lipid Rafts and Activation of Syk-JNK-AP-1 Pathway [PDF]

, 2015
Copyright: © 2015 Huang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source ...
Brown, Gordon D, Chen, Wen-Yu, Chu, Ching-Liang, Chuu, Chih-Pin, Huang, Juin-Hua, Lin, Ching-Yu, Wu, Sheng-Yang, Wu-Hsieh, Betty A   +7 more
core   +4 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source