Aging of the Hematopoietic System: Mechanisms, Consequences, and Systemic Interactions
Hematopoietic aging arises from intrinsic stem‐cell decline and bone‐marrow niche dysfunction, leading to myeloid skewing, immunosenescence, and clonal hematopoiesis. These changes drive systemic inflammation and multi‐organ disease, which in turn further disrupt the bone‐marrow niche and hematopoietic stem cell (HSC) function, creating a vicious cycle
Masashi Miyawaki +3 more
wiley +1 more source
Retraction Note: The P-selectin and PSGL-1 axis accelerates atherosclerosis via activation of dendritic cells by the TLR4 signaling pathway. [PDF]
Ye Z +7 more
europepmc +1 more source
Prospective cohort study evaluating risk factors for the development of pasture-associated laminitis in the United Kingdom [PDF]
Arita +74 more
core +2 more sources
Biologics to Treat Atopic Dermatitis: Effectiveness, Safety, and Future Directions
ABSTRACT Atopic dermatitis (AD) is one of the most common chronic inflammatory skin diseases worldwide. The clinical presentation of AD is heterogeneous and is characterized by a relapsing and remitting course. Most patients suffer from mild AD while approximately 5% to 20% experience severe disease activity, which often requires systemic treatment ...
Marjolein S. de Bruin‐Weller +9 more
wiley +1 more source
Ultrasound-activated and P-selectin-targeted liposomes overcome biofilm barriers for surgical site infections therapy. [PDF]
Liu X +10 more
europepmc +1 more source
Increasing Soluble P-Selectin Levels Predict Higher Peripheral Atherosclerotic Plaque Progression. [PDF]
Sommer P +7 more
europepmc +1 more source
Adhesion molecules in the maternal–fetal interface in healthy pregnancies and preeclampsia
This study revealed elevated levels of adhesion molecules in the maternal circulation and reduced levels in the fetal circulation in preeclampsia. The findings suggest systemic maternal endothelial dysfunction in preeclampsia. Lower fetal adhesion molecule levels warrant further study. Abstract Introduction Adhesion molecules are markers of endothelial
Ingrid Kverndalen Frisch +4 more
wiley +1 more source
A role for P-selectin and complement in the pathological sequelae of germinal matrix hemorrhage. [PDF]
Hatchell D +8 more
europepmc +1 more source

