Results 201 to 210 of about 18,638,167 (297)

Trichostatin A Sensitizes Tumor Cells to Apoptosis Induced by Soluble Trimeric TRAIL‐Expressing Human Mesenchymal Stromal Cells

Cancer Science, Volume 117, Issue 2, Page 456-467, February 2026.
Human mesenchymal stromal cells (MSCs) were engineered to secrete an isoleucine‐zippered soluble trimeric TRAIL (SCZT) and evaluated with trichostatin A (TSA) to overcome TRAIL resistance. TSA upregulated DR5 and amplified caspase‐8–dependent apoptosis in vitro; in vivo, tumor‐homing MSCs combined with TSA suppressed the growth of both TRAIL‐sensitive ...
Ryosuke Uchibori, Ken Ohmine, Keiya Ozawa   +2 more
wiley   +1 more source

P-selectin overexpression impairs hematopoietic stem cell homeostasis via inflammatory receptor-mediated proliferation and differentiation. [PDF]

Cell Death Dis
He W, Qiu H, Feng Y, Qiu Q, Zheng L, Pan C, Cui X, Sun Y, Wang B, Hu Y.   +9 more
europepmc   +1 more source

Dual phenotypic characteristics of P-selectin in a mouse model of hemorrhagic shock and hepatectomy. [PDF]

Heliyon, 2023
Chen JL, Cheng TT, Huang CC, Chang HH, Lam CF.   +4 more
europepmc   +1 more source

Pharmacophore‐Based Identification and Molecular Characterization of Potent Neprilysin Inhibitors: Biochemical and Therapeutic Implications for Cardiovascular Diseases

Chemical Biology &Drug Design, Volume 107, Issue 2, February 2026.
Pharmacophore‐based virtual screening and molecular dynamics identified pentagalloylglucose and tannic acid as potent, non‐toxic neprilysin inhibitors. These natural compounds demonstrated strong binding affinity and stable interactions with the catalytic Zn2+ site, offering promising leads for cardiovascular drug development. ABSTRACT Neprilysin (NEP),
Chung‐Ting Kuo, Yi‐Chen Wu, Ji‐Min Li, Tz‐Chuen Ju, Tien‐Sheng Tseng   +4 more
wiley   +1 more source

Neutrophils Induce P-Selectin Shedding from Activated Platelets Via Neutrophil Elastase. [PDF]

Inflammation
Huang Y, Ling L, He S, Liu C, Huang X, Wang S, Yu Z, Zhou J.   +7 more
europepmc   +1 more source

Platelet-derived circulating soluble P-selectin is sufficient to induce hematopoietic stem cell mobilization. [PDF]

Stem Cell Res Ther, 2023
Wang TF, Liou YS, Yang SH, Lin GL, Chiang YW, Lien TS, Li CC, Wang JH, Chang HH, Sun DS.   +9 more
europepmc   +1 more source

P-Selectin Glycoprotein Ligand (PSGL)-1 Expression on CD4⁺ T Cells in Patients with HIV: Insights from an Observational Study. [PDF]

Pathogens
Zaongo SD, Wan Y, Zhang L, Tang S, Harypursat V, Chen Y.   +5 more
europepmc   +1 more source

P-Selectin mediates targeting of a self-assembling phototherapeutic nanovehicle enclosing dipyridamole for managing thromboses. [PDF]

J Nanobiotechnology, 2023
Liu CH, Jheng PR, Rethi L, Godugu C, Lee CY, Chen YT, Nguyen HT, Chuang EY.   +7 more
europepmc   +1 more source

T Cell Exhaustion in Hepatocellular Carcinoma: A Substantial Barrier in Immunotherapy

Journal of Cellular and Molecular Medicine, Volume 30, Issue 3, February 2026.
ABSTRACT Hepatocellular carcinoma (HCC), accounting for over 90% of primary liver cancers, remains a major global challenge for healthcare professionals. While immunotherapy has transformed the landscape of cancer treatment, its success is often limited by immune resistance, particularly through T cell exhaustion which remains a major barrier to ...
Kosar Nouri, Negar Asadollahei, Yasamin Haghir‐Sharif‐Zamini, Homeyra Seydi, Mahsa Salehi, Mehrnaz Mesdaghi, Mustapha Najimi, Massoud Vosough   +7 more
wiley   +1 more source

Acute pain in pediatric patients with SCD without chronic pain is associated with elevated VCAM-1 and P-selectin adhesion. [PDF]

Blood Vessel Thromb Hemost
Martin OY, Borhan R, Zaidi AU, Gao X, Ribbiso K, Darbari DS, Hines PC, Campbell AD.   +7 more
europepmc   +1 more source