Results 31 to 40 of about 7,902 (230)

p130Cas over-expression impairs mammary branching morphogenesis in response to estrogen and EGF. [PDF]

PLoS ONE, 2012
p130Cas adaptor protein regulates basic processes such as cell cycle control, survival and migration. p130Cas over-expression has been related to mammary gland transformation, however the in vivo consequences of p130Cas over-expression during mammary ...
Maria del Pilar Camacho Leal, Alessandra Pincini, Giusy Tornillo, Elisa Fiorito, Brigitte Bisaro, Elisa Di Luca, Emilia Turco, Paola Defilippi, Sara Cabodi   +8 more
doaj   +1 more source

P130Cas/bcar1 mediates zebrafish caudal vein plexus angiogenesis [PDF]

Scientific Reports, 2020
AbstractP130CAS/BCAR1 belongs to the CAS family of adaptor proteins, with important regulatory roles in cell migration, cell cycle control, and apoptosis. Previously, we and others showed that P130CAS mediates VEGF-A and PDGF signalling in vitro, but its cardiovascular function in vivo remains relatively unexplored.
Wisniewski, L, French, V, Lockwood, N, Valdivia, LE, Frankel, P   +4 more
openaire   +3 more sources

Src, p130Cas, and Mechanotransduction in Cancer Cells [PDF]

Genes & Cancer, 2012
Anchorage-independent growth is the most significant hallmark of cell transformation, which has an intimate relevance to cancer. Anchorage or adhesion physically links cells to the extracellular matrix and allows the transmission of external mechanical cues to intracellular signaling machineries.
Hiroyuki, Matsui, Ichiro, Harada, Yasuhiro, Sawada   +2 more
openaire   +2 more sources

Inhibition of p130cas tyrosine phosphorylation by calyculin A [PDF]

Journal of Leukocyte Biology, 1998
Abstract P130cas is a dominant tyrosine phosphorylated protein in v-src-and v-crk-transformed cells. Tyrosine phosphorylation also occurs in response to integrin-mediated cell adhesion. P130cas has a unique structure with multiple SH2 and SH3 binding sites, which makes it a candidate docking protein that might be involved in several ...
W, Qiu, R R, Cobb, W, Scholz
openaire   +2 more sources

Cas Adaptor Proteins Coordinate Sensory Axon Fasciculation. [PDF]

, 2018
Development of complex neural circuits like the peripheral somatosensory system requires intricate mechanisms to ensure axons make proper connections. While much is known about ligand-receptor pairs required for dorsal root ganglion (DRG) axon guidance ...
Estep, Jason A, Riccomagno, Martin M, Rosette, Kylee A, Rutlin, Michael L, Vahedi-Hunter, Tyler A, Wright, Kevin M   +5 more
core   +2 more sources

Bcar1/p130Cas protein and primary breast cancer: prognosis and response to tamoxifen treatment [PDF]

, 2000
BACKGROUND: The product of the Bcar1/p130Cas (breast cancer resistance/p130Crk-associated substrate) gene causes resistance to antiestrogen drugs in human breast cancer cells in vitro.
Brinkman, A. (Arend), Dorssers, L.C.J. (Lambert), Flier, S. (Silvia) van der, Foekens, J.A. (John), Klijn, J.G.M. (Jan), Kok, E.M. (Elisabeth), Look, M.P. (Maxime), Meijer van Gelder, M.E. (Marion)   +7 more
core   +1 more source

Ginseng total saponin modulates podocyte p130Cas in diabetic condition [PDF]

Journal of Ginseng Research, 2013
Proteinuric conditions demonstrate structural and compositional changes of the foot processes and slit diaphragms between podocytes. p130Cas in podocytes serves as an adapter protein anchoring glomerular basement membrane to actin filaments of podocyte cytoskeleton.
Ha, Tae-Sun, Lee, Jin-Seok, Choi, Ji-Young, Park, Hye-Young   +3 more
openaire   +2 more sources

PTP1B promotes focal complex maturation, lamellar persistence and directional migration [PDF]

, 2013
Previous findings established that ER-bound PTP1B targets peripheral cell-matrix adhesions and positively regulates cell adhesion to fibronectin. Here we show that PTP1B enhances focal complex lifetime at the lamellipodium base, delaying their turnover ...
Arregui, Carlos Oscar, Burdisso, Juan Eduardo, González, Angela   +2 more
core   +1 more source

Conditional ablation of p130Cas/BCAR1 adaptor protein impairs epidermal homeostasis by altering cell adhesion and differentiation

Cell Communication and Signaling, 2018
Background p130 Crk-associated substrate (p130CAS; also known as BCAR1) is a scaffold protein that modulates many essential cellular processes such as cell adhesion, proliferation, survival, cell migration, and intracellular signaling.
Maria del Pilar Camacho Leal, Andrea Costamagna, Beatrice Tassone, Stefania Saoncella, Matilde Simoni, Dora Natalini, Aurora Dadone, Marianna Sciortino, Emilia Turco, Paola Defilippi, Enzo Calautti, Sara Cabodi   +11 more
doaj   +1 more source

The emerin-binding transcription factor Lmo7 is regulated by association with p130Cas at focal adhesions [PDF]

PeerJ, 2013
Loss of function mutations in the nuclear inner membrane protein, emerin, cause X-linked Emery-Dreifuss muscular dystrophy (X-EDMD). X-EDMD is characterized by contractures of major tendons, skeletal muscle weakening and wasting, and cardiac conduction ...
Michele A. Wozniak, Brendon M. Baker, Christopher S. Chen, Katherine L. Wilson   +3 more
doaj   +2 more sources