Results 41 to 50 of about 7,902 (230)

Expression of p130cas, E-cadherin and β-catenin and their correlation with clinicopathological parameters in non-small cell lung cancer: p130cas over-expression predicts poor prognosis

Folia Histochemica et Cytobiologica, 2012
p130cas (p130 Crk-associated substrate) is a scaffolding protein and plays an important role in regulating focal adhesion and driving cell migration. Also, the destruction of E-cadherin/β-catenin adhesive complex is one of the changes that characterizes ...
Yuan Miao, Ai-Lin Li, Liang Wang, Chui-Feng Fan, Xiu-Peng Zhang, Hong-Tao Xu, Yang Han, Yang Liu, Enhua Wang   +8 more
doaj   +1 more source

Ouabain affects cell migration via Na,K-ATPase-p130cas and via nucleus-centrosome association. [PDF]

PLoS ONE, 2017
Na,K-ATPase is a membrane protein that catalyzes ATP to maintain transmembrane sodium and potassium gradients. In addition, Na,K-ATPase also acts as a signal-transducing receptor for cardiotonic steroids such as ouabain and activates a number of ...
Young Ou, Chen Xuan Pan, Jeremy Zuo, Frans A van der Hoorn   +3 more
doaj   +1 more source

Mechano-transduction: from molecules to tissues. [PDF]

, 2014
External forces play complex roles in cell organization, fate, and homeostasis. Changes in these forces, or how cells respond to them, can result in abnormal embryonic development and diseases in adults.
Dunn, Alexander R, Nelson, W James, Pruitt, Beth L, Weis, William I   +3 more
core   +2 more sources

p130Cas/BCAR1 scaffold protein in tissue homeostasis and pathogenesis [PDF]

Gene, 2015
BCAR1 (also known as p130Cas/BCAR1) is an adaptor protein that belongs to the CAS family of scaffold proteins. In the past years, increasing evidence has demonstrated the ability of p130Cas/BCAR1 to activate signaling originating from mechanical stimuli, cell-extracellular matrix (ECM) adhesion and growth factor stimulation cascades during normal ...
Camacho Leal MD, SCIORTINO, MARIANNA, TORNILLO, GIUSY, COLOMBO, SHANA MARIA, DEFILIPPI, Paola, CABODI, Sara   +5 more
openaire   +2 more sources

Expression levels of the focal adhesion-associated proteins paxillin and p130CAS in canine and feline mammary tumors [PDF]

, 2003
International audiencePaxillin and p130$^{{\rm CAS}}$ are two adaptor proteins localized at the focal adhesions which play an important role in cell signaling, cell motility and oncogenic transformation.
AVALLONE, LUIGI, D'ANGELO, DANILA, DELLA MORTE, ROSSELLA, PELAGALLI, ALESSANDRA, SCIBELLI, ANTONIO, STAIANO, NORMA, TAFURI, SIMONA   +6 more
core   +3 more sources

Dynamics and Mechanism of p130Cas Localization to Focal Adhesions [PDF]

Journal of Biological Chemistry, 2010
The docking protein p130Cas is a major Src substrate involved in integrin signaling and mechanotransduction. Tyrosine phosphorylation of p130Cas in focal adhesions (FAs) has been linked to enhanced cell migration, invasion, proliferation, and survival.
Dominique M, Donato, Larisa M, Ryzhova, Leslie M, Meenderink, Irina, Kaverina, Steven K, Hanks   +4 more
openaire   +2 more sources

Endothelial p130cas Confers Resistance to Anti-Angiogenesis Therapy

SSRN Electronic Journal, 2020
Adaptive resistance to vascular endothelial growth factor (VEGF)–targeted therapies occurs frequently among cancer patients. To investigate the underlying mechanisms, we established an array of orthotopic mouse models of ovarian cancer with adaptive resistance to anti-VEGF antibodies (AVAs).
Yunfei Wen, Anca Chelariu- Raicu, Elaine Stur, Alpa M. Nick, Dahai Jiang, xinhui chen, Nicholas B. Jennings, Wei Hu, Lingegowda S. Mangala, Gabriel Lopez‐Berestein, Mien‐Chie Hung, Anil K. Sood   +11 more
openalex   +2 more sources

Tyrosine Y189 in the substrate domain of the adhesion docking protein NEDD9 is conserved with p130Cas Y253 and regulates NEDD9-mediated migration and focal adhesion dynamics. [PDF]

PLoS ONE, 2013
The focal adhesion docking protein NEDD9/HEF1/Cas-L regulates cell migration and cancer invasion. NEDD9 is a member of the Cas family of proteins that share conserved overall protein-protein interaction domain structure, including a substrate domain that
Jaime B Baquiran, Peta Bradbury, Geraldine M O'Neill   +2 more
doaj   +1 more source

C9orf10/Ossa regulates the bone metastasis of established lung adenocarcinoma cell subline H322L-BO4 in a mouse model. [PDF]

Genes Cells
We established a lung adenocarcinoma cell subline (H322L‐BO4) that specifically showed metastasis to the leg bones and adrenal glands. H322L‐BO4 cells can be used to evaluate the effect of candidate therapeutic targets against bone metastatic lung cancer cells.
Uekita T, Yagi R, Ichimura T, Sakai R.
europepmc   +2 more sources

Focal adhesion kinase contributes to proliferative potential of ErbB2 mammary tumour cells but is dispensable for ErbB2 mammary tumour induction in vivo [PDF]

, 2012
INTRODUCTION: Activation of focal adhesion kinase (FAK) is hypothesized to play an important role in the pathogenesis of human breast cancer. METHODS: To directly evaluate the role of FAK in mammary tumour progression, we have used a conditional FAK ...
AL Lark, C Walsh, DA Hsia, DE White, E Behmoaram, ER Andrechek, GW McLean, GW McLean, H Fan, H Lahlou, Hicham Lahlou, HM Lightfoot, I Tanjoni, J Ursini-Siegel, JK Slack-Davis, KJ Schmitz, KM Ignatoski, L Huck, LH Xu, M Luo, Margaret C Frame, MH Oktay, N Benlimame, P Soriano, PM Siegel, PP Provenzano, R Marcotte, S Cabodi, SM Pontier, SM Rothenberg, SM Weis, V Nurcombe, Virginie Sanguin-Gendreau, WG Roberts, William J Muller, Y Pylayeva   +35 more
core   +1 more source