Mechanical Signaling: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets
MedComm, Volume 6, Issue 12, December 2025.In this review, we summarize cell–ECM interactions and delve into the complex mechanotransduction. We introduce advanced research methods and emerging clinical tools used to study cellular mechanical phenotypes, mechanotransduction, and disease progression. Additionally, we analyze the role of mechanical biomarkers in the development and progression of
Yicen Long +5 more
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Neuropilins 1 and 2 mediate neointimal hyperplasia and re-endothelialization following arterial injury [PDF]
, 2015 AIMS: Neuropilins 1 and 2 (NRP1 and NRP2) play crucial roles in endothelial cell migration contributing to angiogenesis and vascular development. Both NRPs are also expressed by cultured vascular smooth muscle cells (VSMCs) and are implicated in VSMC ...
Evans, I +7 more
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c‐Abl Kinase Targets Tight Junction Protein ZO‐2 in Regulation of Cell Migration and Morphology
The FASEB Journal, Volume 39, Issue 22, 30 November 2025.c‐Abl binds and phosphorylates ZO‐2 directly at its C‐terminus and indirectly at the N‐terminus via JAK1. These phosphorylation events weaken cytoskeletal contractility, lower traction forces, and reduce cell migration, establishing ZO‐2 as a central mediator linking c‐Abl activity to changes in cell morphology and motility.
Doo Eun Choi +5 more
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Ezrin Is Associated with Disease Progression in Ovarian Carcinoma.
PLoS ONE, 2016 ObjectiveEzrin and p130Cas are structural proteins with an important role in signaling pathways and have been shown to promote cancer dissemination. We previously reported on overexpression of both ezrin and p130Cas in breast carcinoma effusions compared
Vered Horwitz +5 more
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The Role of Surface Molecules in Host Responses of Leishmaniasis: Focus on Lipid Mediators [PDF]
Journal of Research in Applied and Basic Medical Sciences, 2022 Leishmaniasis is a neglected disease that affects more than 12 million people worldwide. After parasite inoculum by female blood-sucking insects, e.g. Phlebotomus, neutrophils quickly infiltrate and phagocytes Leishmania parasites.
Ali Fattahi bafghi +3 more
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Mitogenic signaling by Gq/11-coupled receptors [PDF]
, 2004 By binding to their cognate GPCRs, many potent mitogens such as neuropeptides, angiotensin II or lysophosphatidic acid stimulate cell proliferation via engaging the ERK/MAPK cascade. As mentioned before, agonists stimulating Gq/11-coupled
Carell, Thomas, Prof. Dr. +1 more
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Local Growth Hormone Facilitates Aging of the Colon Epithelial Microenvironment
Aging Cell, Volume 24, Issue 10, October 2025.Local growth hormone (GH) is expressed and secreted by senescent cells in the aging human colon. GH triggers epithelial‐to‐mesenchymal transition and activates colon cell motility by regulating extracellular matrix proteins, inducing cytoskeleton rearrangement and altering cell motility protein phosphorylation.
Vera Chesnokova +8 more
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Dysregulation of Blimp1 transcriptional repressor unleashes p130Cas/ErbB2 breast cancer invasion
Scientific Reports, 2017 ErbB2 overexpression is detected in approximately 20% of breast cancers and is correlated with poor survival. It was previously shown that the adaptor protein p130Cas/BCAR1 is a crucial mediator of ErbB2 transformation and that its overexpression confers
Marianna Sciortino +10 more
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Characterization of new substrates targeted by Yersinia tyrosine phosphatase YopH. [PDF]
PLoS ONE, 2009 YopH is an exceptionally active tyrosine phosphatase that is essential for virulence of Yersinia pestis, the bacterium causing plague. YopH breaks down signal transduction mechanisms in immune cells and inhibits the immune response. Only a few substrates
María Luisa de la Puerta +7 more
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CRKL Mediates p110β-Dependent PI3K Signaling in PTEN-Deficient Cancer Cells
Cell Reports, 2017 The p110β isoform of PI3K is preferentially activated in many tumors deficient in the phosphatase and tensin homolog (PTEN). However, the mechanism(s) linking PTEN loss to p110β activation remain(s) mysterious.
Jing Zhang +7 more
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