Dcas supports cell polarization and cell-cell adhesion complexes in development. [PDF]
PLoS ONE, 2010 Mammalian Cas proteins regulate cell migration, division and survival, and are often deregulated in cancer. However, the presence of four paralogous Cas family members in mammals (BCAR1/p130Cas, EFS/Sin1, NEDD9/HEF1/Cas-L, and CASS4/HEPL) has limited ...
Nadezhda Tikhmyanova +3 more
doaj +1 more source
Distinct ligand binding sites in integrin alpha3beta1 regulate matrix adhesion and cell-cell contact. [PDF]
, 2003 The integrin alpha3beta1 mediates cellular adhesion to the matrix ligand laminin-5. A second integrin ligand, the urokinase receptor (uPAR), associates with alpha3beta1 via a surface loop within the alpha3 beta-propeller (residues 242-246) but outside ...
Chapman, Harold A +6 more
core
Cuproplasia and cuproptosis, two sides of the coin
Cancer Communications, Volume 45, Issue 5, Page 505-524, May 2025.Abstract Copper is an essential micronutrient in the human body, mainly acting as a crucial cofactor required for a wide range of physiological processes across nearly all cell types. Recent advances revealed that tumor cells seize copper to fulfill their rapid proliferation, metastasis, immune evasion, and so on by reprogramming the copper regulatory ...
Kaizhong Lu +4 more
wiley +1 more source
Regulation of ectoplasmic specialization dynamics in the seminiferous epithelium by focal adhesion-associated proteins in testosterone-suppressed rat testes [PDF]
, 2005 Apical ectoplasmic specialization (ES) is a unique testis-specific cell-cell actin-based adherens junction type restricted to the Sertoli-round/elongating/elongate spermatid interface in the seminiferous epithelium.
Cheng, CY +5 more
core +1 more source
Decoding the Implications of Zinc in the Development and Therapy of Leukemia
Advanced Science, Volume 12, Issue 9, March 6, 2025.Zinc's pivotal role in hematological development and its therapeutic potential in leukemia are explored. This review delves into the complex interplay of zinc signaling in leukemia progression and treatment. It highlights recent advancements, such as zinc's regulation of ferroptosis and its impact on immunotherapy, underscoring the need for zinc‐based ...
Bo Zhu +9 more
wiley +1 more source
Cas phosphorylation regulates focal adhesion assembly
eLife, 2023 Integrin-mediated cell attachment rapidly induces tyrosine kinase signaling. Despite years of research, the role of this signaling in integrin activation and focal adhesion assembly is unclear.
Saurav Kumar +4 more
doaj +1 more source
CD98hc facilitates B cell proliferation and adaptive humoral immunity. [PDF]
, 2009 The proliferation of antigen-specific lymphocytes and resulting clonal expansion are essential for adaptive immunity. We report here that B cell-specific deletion of the heavy chain of CD98 (CD98hc) resulted in lower antibody responses due to total ...
A Mondino +56 more
core +2 more sources
International Journal of Genomics, Volume 2025, Issue 1, 2025.The role of sphingolipid metabolism (SM) dysregulation in promoting bladder cancer (BLCA) progression and influencing patient prognosis has been well documented. To enhance therapeutic strategies, we aimed to identify key sphingolipid metabolism–related genes (SMGs) and develop a prognostic signature for personalized BLCA management. In this study, 430
Zechun Peng +4 more
wiley +1 more source
Metastatic properties and genomic amplification of the tyrosine kinase gene ACK1 [PDF]
, 2005 Metastasis of primary tumors leads to a very poor prognosis for patients suffering from cancer. Although it is well established that not every tumor will eventually metastasize, it is less clear whether primary tumors acquire genetic alterations in a ...
E. H. van der Horst +39 more
core +1 more source
Supplementary Figure 1 from Acquisition of the Metastatic Phenotype Is Accompanied by H<sub>2</sub>O<sub>2</sub>-Dependent Activation of the p130Cas Signaling Complex [PDF]
, 2023 Nadine Hempel +3 more
openalex +1 more source