Results 81 to 90 of about 208,852 (280)
The chromatin remodelling factor BRG1 is a novel binding partner of the tumor suppressor p16INK4a
Molecular Cancer, 2009 Background CDKN2A/p16INK4a is frequently altered in human cancers and it is the most important melanoma susceptibility gene identified to date. p16INK4a inhibits pRb phosphorylation and induces cell cycle arrest, which is considered its main tumour ...
Mann Graham J +10 more
doaj +1 more source
First Generation Proteolysis Targeting Chimeras (PROTACs) for the Treatment of Progeria
Advanced Science, EarlyView.We report the first PROTACs designed to degrade progerin, introducing a novel therapeutic approach for progeria. The best compound, UCM‐18142, significantly reduces progerin levels and improves key disease phenotypes in patient‐derived cells and in the LmnaG609G/G609G mouse model, paving the way for new treatment strategies targeting the root cause of ...
Jon Macicior‐Michelena +5 more
wiley +1 more source
On the fundamental group of the complement of a complex hyperplane arrangement
, 2015 We construct two combinatorially equivalent line arrangements in the complex projective plane such that the fundamental groups of their complements are not isomorphic.
D. J. A. Welsh +8 more
core +1 more source
The specificity and patterns of staining in human cells and tissues of p16INK4a antibodies demonstrate variant antigen binding [PDF]
, 2013 The validity of the identification and classification of human cancer using antibodies to detect biomarker proteins depends upon antibody specificity. Antibodies that bind to the tumour-suppressor protein p16INK4a are widely used for cancer diagnosis and
A Melck +34 more
core +3 more sources
Advanced Science, EarlyView.Colorectal cancer is characterized by an immunosuppressive microenvironment that limits immunotherapy efficacy. We identify a senescence‐like state in germinal center B cells driven by the PRELID1–VDAC3 axis, which promotes IL‐7 secretion, alleviates CD8+ T‐cell exhaustion, and enhances antitumor immunity. Targeting this pathway improves responsiveness
Yuhan Liao +8 more
wiley +1 more source
p16(INK4A) expression in invasive laryngeal cancer
Papillomavirus Research, 2016 We examined p16 expression in tumors from a population-based sample of laryngeal cancer cases diagnosed in the U.S. Samples had been previously genotyped for HPV DNA.Overall, p16 expression was observed in laryngeal tissue from 8 of 101 (7.9%) cases. p16
Brenda Y. Hernandez +12 more
doaj +1 more source
Advanced Science, EarlyView.The cover image shows that vascular endothelial cells play an important role in lung metastasis of TNBC. Endothelial Sohlh2 acts as a gatekeeper against TNBC lung metastasis by limiting endothelial activation and tumor cell passage. PRMT5 reduces Sohlh2 stability, weakening this protective barrier.
Ruihong Zhang +8 more
wiley +1 more source
Expression of Anion Exchanger 1 Sequestrates p16 in the Cytoplasm in Gastric, Colonic Adenocarcinoma
Neoplasia: An International Journal for Oncology Research, 2007 p16INK4A (p16) binds to cyclin-dependent kinase 4/6, negatively regulates cell growth. Recent studies have led to an understanding of additional biologic functions for p16; however, the detailed mechanisms involved are still elusive.
Wei-Wei Shen +6 more
doaj +1 more source
Liver: Intrahepatic cholangiocarcinoma [PDF]
, 2009 Review on Liver: Intrahepatic cholangiocarcinoma, with data on clinics, and the genes ...
Aishima, S, Enjoji, M
core +1 more source
Australian Journal of Social Issues, EarlyView.ABSTRACT While Australia's National Disability Insurance Scheme (NDIS) was founded on principles of choice and control, for people with significant mental health challenges (what the NDIS calls ‘psychosocial disability’) these ideals often remain elusive. Support systems continue to be fractured and in the context of ongoing policy reforms, it is vital
Joel Hollier, Jennifer Smith‐Merry
wiley +1 more source